At the 49th MBSJ Annual Meeting (held as BMB2026), we will host two lunchtime seminars entitled "Is 'Just Put Up with Being Poor' Outdated? Young Researchers and Financial Issues" and "How Can We Buil...

Expression of RNA polymerase II–dependent genes was significantly reduced in JHOC5 and BRG1-S1452A cells, suggesting a role for BRG1 phosphorylation in RNA polymerase II–dependent gene expression. In...

The IκBα nuclear export signal drives oscillatory dynamics of RelB in the noncanonical NF-κB pathway. Following LTβR stimulation, p100 processing releases RelB for nuclear import, while IκBα-mediated...

Partial depletion of SART1 selectively induces spindle defects and cell death in cancer cells while sparing normal cells. c-Myc–mediated transformation confers sensitivity to SART1 depletion, providi...

Persistent homology quantifies chromatin dynamics from single-cell fluorescence images. Coupled with unsupervised machine learning, this approach reveals cellular trajectories and provides insight in....

We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4-LR mutant...

At the 49th MBSJ Annual Meeting (held as BMB2026), we will host two lunchtime seminars entitled "Is 'Just Put Up with Being Poor' Outdated? Young Researchers and Financial Issues" and "How Can We Buil...

The new GPR151 ligands altered the analgesic effects of morphine.

LINE-1 elements are actively transcribed in human pluripotent stem cells. Pluripotency-associated transcription factors bind to young LINE-1 loci to attenuate their transcription. Loss of these facto...

Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins a...

The expression pattern of bero in the Drosophila larval central nervous system was analyzed using a combination of the T2A GAL4 system and scRNA-seq analysis. bero was expressed in several peptidergi...

The epilepsy-associated DSCAML1 A2105T mutation causes intracellular protein accumulation and loss of surface expression. We demonstrate that the chemical chaperone 4PBA restores surface localization...

Polyphosphate (polyP) is a universal and multifunctional biopolymer whose essential roles remain elusive. In fission yeast, endogenous vacuolar polyP supports cellular survival by maintaining phospha...

This study analyzes transposable element dynamics in Arabidopsis thaliana herbarium specimens collected in Germany (1817–1957) using whole-genome sequencing and the TEF program. We identified 331 TE ...

Under nutrient-rich conditions, Ifh1 recruited to the RPG promoters by the FHA domain of Fhl1 promotes growth while masking the latent inhibitory activity of Fhl1. Upon starvation or stress, dissocia...

Microridges are laterally elongated epithelial protrusions. The I-BAR protein Baiap2l1a regulates membrane curvature and is essential for microridge morphogenesis. An intact I-BAR domain structure is....

Transient expression of SOX10 and OLIG2(S147A) in human pluripotent stem cells promoted efficient oligodendrocyte maturation, yielding ~20% MBP-positive cells within 25 days. This simple protocol hig...

ISPO2025 brought together international leaders and trainees to discuss how protein and organelle lifetime is set by the ubiquitin–proteasome system and autophagy, and how these pathways can be measu...