Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...

Interplay between major global challenges and human health. Climate change and sociopolitical polarisation act as overarching amplifiers, driving specific environmental and psychosocial/policy-relate...

Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...

Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor microenvironment is the he...

AbstractBackground. Cancer immunotherapy with engineered T cells has become a standard treatment for certain haematological cancers. However, clinical tria

Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.

#Serendipity | Delighted to share this lovely post from the hugely talented Austeja Baleviciute of the Karolinska Institutet 😊 Hopefully will offer some useful tips to early career researchers as they...

Towards a pan-#Flu #Vaccine | Identification of a Seasonal Influenza Vaccine-induced Broadly #Protective Neuraminidase #Antibody | Breaking Open Access Study at Rockefeller University Press #JEM | #Bc...

BioHub-based Celentyx Ltd is a highly specialised contract research organisation (CRO) that delivers services across a broad range of therapeutic areas…

Autoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-...

Radiotherapy not only kills tumors but also shapes immunity. This study reveals that in radioresistant tumors, clinically relevant radiotherapy induces GM-

Vaccines containing peptides called antigens are bad at stimulating key immune cells called killer T cells. A molecule now enables antigens to encounter these T cells.

#Bcells | "STALK-ing 'Flu" at #Immunity Cell Press: "Playing the Long Game" | Major #VaccineDesign Study by Jenna Guthmiller et al Now Breaking Online | In…

Next-generation influenza vaccines aim to overcome the limitations of current seasonal vaccines and generate durable and broadly protective immunity against influenza by targeting conserved epitopes. ...

Come and see us at poster #5 Celentyx Ltd at the British Society for Immunology day in Oxford

AbstractIntroduction. The application of neoadjuvant immunotherapy in esophageal squamous cell carcinoma (ESCC) reactivates anti-tumour immune responses an

Abstract. Fc receptors (FcR) play a key role in coordinating responses from both the innate and adaptive immune system. The inhibitory Fc gamma receptor (F

Abstract. Long-lasting immunological memory is a core feature of the adaptive immune system that allows an organism to have a potent recall response to for

#Cancer | #Tumour #Immunity | #CTLA4: "A Tale of Two Pathways" | Breaking OPEN ACCESS Review Online from Frank Ward & Co. | BOTH #Tregs-Depletion AND…

In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunothera...

Macrophages execute core functions in maintaining tissue homeostasis, in which their extensive plasticity permits a spectrum of functions from tissue …

#Tregs: Head-to-Head; One-by-One | #SingleCell #Suppression Profiling of Human #regulatoryTcells | Jonas N. Søndergaard et al drill down to individual Effector…

Tumor-associated extrafollicular B cells are phenotypically, locationally, and functionally distinct from germinal center–dependent memory B cells.

#Cancer | #Immunotherapy | #NKcells | #CD8α and #CD70 mark #Human NK populations differing in #Cytotoxicity | Daniel Davis & Co.'s "I.D. Parade" finger Mass…

#Immunotherapy | Coordinated #Macrophage ↔ #Tcells interactions mediate response to #ImmuneCheckpointBlockade in #Colorectal #Cancer | Multiple Immune…

Gut IgA enhances systemic IgG responses to pneumococcal vaccines through a complex mechanism involving peripheral B and T cells.