Research updates, scholarly work, code and datasets from the Prism team. Filter by topic and by the kind of output you are after.

Dynamic structural data, models, and language to become standard across the field. At scale, this is how we predict conformational ensembles across all of biology.

Podcast Episode · The Tortured Proteins Department · September 8 · 27m

Dynamic structural data, models, and language to become standard across the field. At scale, this is how we predict conformational ensembles across all of biology.

Static structures cannot tell us what makes a designed enzyme functional, what drives drug efficacy and resistance, or how to engineer motion itself.

Dynamic structural data, models, and language to become standard across the field. At scale, this is how we predict conformational ensembles across all of biology.

diffuse scattering reproducible, yay!

Mdx2 is a powerful and open-source toolkit for diffuse data processing.

An Ensemble Dataset of over 60,000 Structures

An Ensemble Dataset of over 60,000 Structures

In preparation for hierarchical hetereogeneity encoding, BANDICOOT has a new, more intuitive display mode for alternate conformations.

A playground for the PDBx/mmCIF file exploration, a look at the current proposal for encoding correlated heterogeneity

Towards a complete forward model of diffuse scattering

Reviving Coot 0.9 for MacOS Tahoe as Bandicoot, a bespoke and integrated molecular modeling environment.

Leakage-free Training to Predict Protein Function

diffUSE has 15 repositories available. Follow their code on GitHub.

allow user to override default solvent with externally-supplied mtz file - jmholton/phenix_user_solvent

Structural biology increasingly relies on machine learning-based structure predictors, enabling accurate atomic-level structure prediction at scale. However, predicting conformational ensembles…

Framework for modified sampling from biomolecular generative models - diff-use/sampleworks

ABOUT DIFFUSE The DiffUSE Project is building open infrastructure to study protein dynamics using experimental data. The project spans wet-lab collaborators, computational scientists, ML researchers,…

The DiffUSE Project

The systems that enable how we fund, do, and build upon science have long needed an update.

Expanding The DiffUSE Project

Today, Astera Institute is launching Radial, a division which reimagines how life sciences research happens at a systems level.

A new nonprofit called Radial is launching with at least $500 million to modernize the scientific process for the AI era.