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Ines Saenz-de-Santa-Maria

@ines-ssm.bsky.social
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Reposted by Ines Saenz-de-Santa-Maria
Jean-Yves Tinevez @jytinevez.bsky.social · 22/09/2026
The images in this work are amazing, but. Sometimes the signal coming from the organelles was low. Since they travel along a line, the TNT, image analysis techniques that are based on dimensionality, like kymographs (imagej.net/tutorials/ge...), should work well
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Jean-Yves Tinevez @jytinevez.bsky.social · 22/09/2026
But in our case, the cells and hence the TNT, move during the movie:
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Reposted by Ines Saenz-de-Santa-Maria
Jean-Yves Tinevez @jytinevez.bsky.social · 22/09/2026
So to address this, we created a tool that allows performing kymograph analysis on a line that moves and change over time. It's implemented as a #TrackMate extension, that you will use to track the extremities of the kymograph line over time imagej.net/plugins/trac...
imagej.net
TrackMate Kymograph
Generating and analyzing kymographs with TrackMate
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Jean-Yves Tinevez @jytinevez.bsky.social · 22/09/2026
And that you can use to register, analyze and track organelles transiting across a tube.
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Jean-Yves Tinevez @jytinevez.bsky.social · 22/09/2026
Many thanks to @ines-ssm.bsky.social and Chiara for taking us on this project. The tool is meant to be widely usable and you will find above a link to tutorials. Enjoy!
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Reposted by Ines Saenz-de-Santa-Maria
Jean-Yves Tinevez @jytinevez.bsky.social · 22/09/2026
I'd like to introduce a piece of work we did for the paper of @ines-ssm.bsky.social and colleagues in the lab of Chiara Zurzolo in @pasteur.fr www.nature.com/articles/s41...
nature.com
Tunneling nanotubes regulate mitochondrial homeostasis between glioblastoma and astrocytes, and between tumor cells in vivo - Nature Communications
Tunneling nanotube-like (TNT) connections allow mitochondrial exchange between tumor cells and its tumor microenvironment. Here, the authors show that TNT connections mediate bidirectional mitochondri...
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Nature Communications @natcomms.nature.com · 15/09/2026
Tunneling nanotube-like connections shown to mediate bidirectional mitochondrial transfer between glioblastoma tumor cells and astrocytes in vitro, and between head and neck squamous cell carcinoma cells in vivo doi.org/10.1038/s414...
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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 18/09/2026
Two-way mitochondrial transfer between GBM tumour cells & astrocytes via nanotubes – a tumour adaptation that could be targeted 📹 Ines Saenz-de-Santa-Maria et al, @pasteur.fr @upcite.bsky.social in @natcomms.nature.com ➡️ bpod.org.uk/archive/2026...
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