Tracking the biological age of grafted organs suggests that donor pools could be expanded to boost organ availability.

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Agarwal et al. introduce MitoSpace, a self-supervised model trained on 4D lattice light-sheet microscopy data. The model resolves drug-induced mitochondrial phenotypes without labels, predicts membrane potential from morphology and dynamics, generalizes to unseen perturbations and lung organoids, and shows that representation quality improves progressively from 2D to 4D.

More than twenty years ago, the FANTOM consortium uncovered that mammalian genomes are pervasively transcribed, revealing multitudes of RNAs with unknown functions. A subset of these transcripts has s...

Snake embryos coil, but how and why they corkscrew remains unexplored. Weber et al. find that the embryos wind up clockwise via buckling of the rapidly elongating axial body against the slow-growing, ...

Sie ist wieder da - die Debatte um ein Verbotsverfahren gegen die AfD. Anlass ist ein Gutachten, das die AfD als verfassungsfeindlich einstuft.

A fresh approach to trialling treatments for rare genetic diseases could make their production an economically viable prospect at last.

▪ Abstract The most studied example of transmission ratio distortion (TRD) in mice is that of the t-complex. This is a variant region of Chromosome 17 which exists as a polymorphism in wild mice. Male...

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

Genes & Immunity - Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer

Interspecies PSC co-culture induces horizontal RNA transfer that activates innate immunity in “winner” mouse cells, a response that is alleviated by Mavs deletion, thereby enhancing “loser” human PSC survival and chimerism.

Cancer biologist - Group Leader at the Georg-Speyer-Haus Institute (GSH) and FCI in Frankfurt - Passionate about tumor microenvironment & immunology

RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...