Europe PMC is an archive of life sciences journal literature.

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that co...

Heart rate continuously adjusts to accommodate perception and action, and these shifts are frequently explained through predictive processes. Yet direct evidence that interbeat intervals exhibit grade...

Placing too much emphasis on a specific interpretation of dimensionality may lead neuroscience down the wrong path.

The authors show that human neurons in bilateral corticolimbic sites fire together, modulated by working memory, and reinstate stimulus-selective firings when both sites briefly oscillate at 90 Hz, su...

Classical serotonergic psychedelics primarily exert their profound effects through agonism at the serotonin 2 A (5-HT2A) receptor, which is abundantly…

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

Preprints don’t change much after peer review — and are rarely retracted.

We rapidly distinguish familiar from novel objects, but how the brain learns this remains unclear. Using macaque inferotemporal cortex recordings and modeling, the authors show that familiarity learni...

This review integrates computational approaches to provide a unified view on how data analysis methods, biophysical mechanistic models and machine learning approaches can help to uncover the origins a...

Abstract. The waxing and waning cortical oscillatory power correlates with function and disease. This cross-trial variability has been thought to be due to

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

Depression is marked by anhedonia, social withdrawal, and a diminished capacity to learn from positive experiences—features that can be framed within predictive processing. Here, we review findings fr...

Scientific Data - The Brain, Body, and Behavior Dataset (BBBD): Multimodal Recordings during Educational Videos

Judea Pearl, a chancellor’s professor emeritus of computer science at the UCLA Samueli School of Engineering, has been named one of 50 AI Pioneers by nonprofit think tank Boston Global Forum and its A...

Using direct recordings from the human brain, Frank et al. show that hippocampal ripples increase ahead of unpredictable events and tune the visual cortex to respond faster and more strongly to surpri...

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

A brain–machine interface is used in monkeys to investigate the biophysical underpinnings of cortical high gamma-band activity, a signal that is often studied in the context of many brain functions.

Frequently ignored bodily rhythms may be skewing neuroscience experiments

Wide-scale recordings reveal neurons in the human brain that encode fundamental components of language such as the grammatical relationships between words, their parts of speech and the...

Disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data.