iiinova — where your digital self keeps evolving

Martijn Arns @martijn-arns.bsky.social · 22/09/2026

We have a new shared #1 on the TDBRAIN Diagnostic challenge: congrats Tijl Cresens, joining Qiang Li at the top with a replicated balanced accuracy of 63%! Also new: participants datasheet V3.1 is live — all participants, please re-download (see FAQ). www.brainclinics.com/research/art...

brainclinics.com

TDbrain Challenge

This page presents the TDBRAIN Leaderboard with blinded replications validating clinically actionable biomarkers using unseen data. Researchers can submit predictions for independent out-of-sample val...

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Martijn Arns @martijn-arns.bsky.social · 08/09/2026

We've updated the TDBRAIN Prize rules to V1.1. See the updated Rules & Regulations and newly added FAQs on our website: www.brainclinics.com/research/bra... €10,000 still unclaimed...

brainclinics.com

Brainclinics Foundation Prize

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Martijn Arns @martijn-arns.bsky.social · 01/09/2026

Want to win €10,000 for a prediction that matters? In collaboration with and co-funded by Alto Neuroscience we hereby launch the Brainclinics Foundation Prize for Predictive Biomarkers. www.brainclinics.com/research/bra...

brainclinics.com

Brainclinics Foundation Prize

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Martijn Arns @martijn-arns.bsky.social · 26/08/2026

New successful TDBRAIN replication: Congratulations Hamoon Heshmati with a succesful replication on predicting remission to TMS using EEG only in Depression with an nPPV=133%! 10% higher than the previous lead and now in #1! These results are getting in the realm of clinically meaningful results.

brainclinics.com

TDbrain Challenge

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Martijn Arns @martijn-arns.bsky.social · 25/08/2026

Great read about the history of Ibogaine (Ona & Marie, 2026) with many new insights uncovered in most ibogaine publications, showing early interest in Brazil and Mexico as early as 1909-1910, with first case report from 1913 on alcohol use disorder and ibogaine... www.akjournals.com/view/journal...

akjournals.com

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Martijn Arns @martijn-arns.bsky.social · 07/07/2026

New Compass Psilocybin Ph3 readout: The question is not so much 'if' it works, but more 'how' it should be clinically implemented with repeat dosing.

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Martijn Arns @martijn-arns.bsky.social · 02/07/2026

We just released a major update to TDBRAIN V3.1: one of the largest and most well phenotyped, openly available clinical EEG datasets (>1500 EEGs).

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TMSMultiLab @tmsmultilab.bsky.social · 17/06/2026

Effect of pulse width and shape on transcranial magnetic stimulation induced heart-brain coupling by Zwienenberg L et al 2026 doi.org/10.1016/j.br... ⚡🧠 🧲 #TMS #BrainStim

doi.org

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Martijn Arns @martijn-arns.bsky.social · 22/06/2026

Postitive top-line Ph3 results for Definium DT120 (LSD) in MDD. Exciting and great to see a clear signal. Response and remission rates at 35-24% however seem relative low compared to the MDD treatment landscape. I hope real-life effectiveness data will get better when integrating with psychotherapy.

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Martijn Arns @martijn-arns.bsky.social · 22/06/2026

Great application of Heart-Brain Coupling: Investigating effects of TMS pulse-width and pulse-shape on frontal excitability, just out in Brain Stimulation Journal. doi.org/10.1016/j.br...

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Martijn Arns @martijn-arns.bsky.social · 18/06/2026

Why health authorities should endorse rTMS for treatment-resistant depression. doi.org/10.1016/j.tr... Nice overview of the current evidence for both the efficacy and effectiveness of TMS in the treatment of depression.

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Martijn Arns @martijn-arns.bsky.social · 18/06/2026

New preprint: We investigated the safety of ibogaine in 19.071 patients across 11 international clinics and in an updated systematic review. We wanted to see if the introduction of the ibogaine safety guidelines in 2016 has made administration of ibogaine safer. Here's what we found:

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Martijn Arns @martijn-arns.bsky.social · 16/06/2026

Always wanted to open EDF/BDF files (EEG or ECG) on Apple or other platforms? We just released an online EDF and BDF viewer, you can open, apply filters, change montages, identify PQRST components in ECG data and save all changes and add ECG component annotations to EDF+ or BDF+ files.

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Martijn Arns @martijn-arns.bsky.social · 27/05/2026

Look forward presenting a keynote and workshop at ISNR conference in Las Vegas in August. Will focus on Heart-Brain Coupling and QEEG-based Stratified Psychiatry in ADHD and Depression. See you there? web.cvent.com/event/cdfcfc...

web.cvent.com

34th Annual ISNR Conference 2026

Join me for this event: 34th Annual ISNR Conference 2026

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Martijn Arns @martijn-arns.bsky.social · 22/04/2026

Look forward to presenting @UCLA on alpha frequency and heart-brain coupling as biomarkers for personalized TMS.

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Martijn Arns @martijn-arns.bsky.social · 10/03/2026

Looking forward presenting tomorrow, will bridge the gap between biofeedback and TMS-induced Heart-Brain Coupling. Online meeting, so accesible from anywhere... See you there! aapb.starchapter.com/meetinginfo....

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Martijn Arns @martijn-arns.bsky.social · 06/03/2026

Impressive results by AtaiBeckley re BPL-003: 76% remission after just 2 doses (8mg+12mg) after 2 mo. in Ph2B. Higher than other interventional psychiatry tx such as accelerated TMS, requiring less time.

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Martijn Arns @martijn-arns.bsky.social · 02/03/2026

What do we do after a patient responds to rTMS? Taper? Monthly maintenance? Wait for relapse and retreat? Just published a consensus statement (NL+Belgium) reviewing 22 studies on maintenance rTMS and combining this with clinical survey data and patient input. www.sciencedirect.com/science/arti...

doi.org

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Martijn Arns @martijn-arns.bsky.social · 20/02/2026

Low heart-rate as a predictor for TMS response: Sometimes the simpler metric is better than the more complex metrics: No effects of complexity/non-linear HRV measures, but low heart-rate robustly predicts better response to TMS (HF and LF TMS), replicated in SAINT iTBS sample.

sciencedirect.com

Complexity or simplicity? A replication analysis of low heart rate as a predictor of TMS response in major depressive disorder

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Martijn Arns @martijn-arns.bsky.social · 18/12/2025

Just came back from Palestine and really enjoyed training the UEF teams from Betlehem and Nablus on the use of TMS in mental health. We also donated two TMS systems for use in Bethlehem and Nablus, which makes it the first TMS available in Palestine!

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Rich Haridy @richharidy.bsky.social · 12/12/2025

Whether it's clinically better than racemic MDMA I couldn't say but here is a good piece from Gill Bedi looking at what we know...

nature.com

Is the stereoisomer R-MDMA a safer version of MDMA? - Neuropsychopharmacology

Neuropsychopharmacology - Is the stereoisomer R-MDMA a safer version of MDMA?

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Martijn Arns @martijn-arns.bsky.social · 05/12/2025

Stanford University obituary for Nolan Williams. You're missed Nolan... med.stanford.edu/news/all-new...

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Martijn Arns @martijn-arns.bsky.social · 05/11/2025

Just out in TMS: Here we explain in more detail the differences between NCG-TMS and Heart-Brain Coupling in response to work from Mark George's group on heart-rate as a biomarker for TMS. Together with John Coetzee and Nolan Williams doi.org/10.1016/j.tr...

doi.org

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Martijn Arns @martijn-arns.bsky.social · 12/10/2025

We've lost a pioneer, an innovator, great mentor and friend. We'll terribly miss you Nolan...

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Martijn Arns @martijn-arns.bsky.social · 03/10/2025

What a great TMS Masterclass we just had, great engaging group of attendees and speakers from across the globe and learnt a lot on the latest in TMS and Brain Stimulation.

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Andreas Horn @andreashorn.org · 01/10/2025

Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!

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Martijn Arns @martijn-arns.bsky.social · 18/09/2025

Just published: A study on the clinical effectiveness of transitioning to right lateral OFC-TMS following unsuccessful use of sequential bilateral DLPFC-TMS for major depression. Read more about the study at: doi.org/10.1016/j.tr...

doi.org

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Martin Dresler @dresler.bsky.social · 10/09/2025

Disturbed sleep is a leading symptom and likely causal factor for the development of psychiatric diseases such as mood disorders. Here we review how sleep is altered in depression, and discuss the role of sleep for therapeutic approaches: www.biologicalpsychiatryjournal.com/article/S000...

biologicalpsychiatryjournal.com

Sleep Neurophysiology in Depression

Sleep disturbances are both a primary symptom of and risk factor for major depressive disorder (MDD). Sleep alterations in MDD include the presence of insomnia or hypersomnia and aberrations in sleep ...

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Micah G. Allen @micahgallen.com · 27/08/2025

Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇

medrxiv.org

Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation

Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...

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Martijn Arns @martijn-arns.bsky.social · 28/08/2025

Just a handful of places still available for our TMS Certification Course and Masterclass. Hope to see you there! Sign-up here: brainclinics.com/masterclass/...

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Martijn Arns @martijn-arns.bsky.social · 27/08/2025

New editorial with Niels Birbaumer & Tato Sokhadze: rdcu.be/eCB 🧠 Neurofeedback & BCIs started in the 1930s, in a Wall Street tycoon’s mansion lab, and now going main stream in Silicon Valley...

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Martijn Arns @martijn-arns.bsky.social · 11/08/2025

TMS also stimulates the trigeminal nerve which can result in clinical benefit independent of its direct cortical stimulation. TENS sham procedures help control for these effects, however such studies should be adequately powered since some level of response to just TENS sham are expected.

doi.org

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Martijn Arns @martijn-arns.bsky.social · 14/07/2025

Join us for the 2025 TMS Masterclass & Certification Course — taking place September 30 to October 2 in Nijmegen, The Netherlands. 📍 Don’t miss your chance to be part of it! 👉 Secure your seat now: brainclinics.com/masterclass/...

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Martijn Arns @martijn-arns.bsky.social · 14/07/2025

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Martijn Arns @martijn-arns.bsky.social · 01/07/2025

Yesterday, we celebrated the culmination of a remarkable journey with the completion of the 10th Brainclinics Foundation PhD. This milestone has yielded a wealth of insights and discoveriesnew that have positively impacted numerous patients worldwide. All theses: brainclinics.com/resources/br...

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Martijn Arns @martijn-arns.bsky.social · 01/07/2025

Yesterday Amourie Prentice succesfully defended her PhD, join me in congratulating her with a great achievement. Her PhD focused on EEG biomarkers and treatment resistance and several chapters that advanced our understanding of Orbitofrontal cortex TMS in depression as a novel TMS target.

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Martijn Arns @martijn-arns.bsky.social · 03/06/2025

New speaker announcement: Joseph Taylor (Harvard University) will present at the Brainclinics TMS Masterclass and Certification Course his latest results and insights titled: From Scalp to Circuit: Evolving TMS Targeting Approaches.

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Martijn Arns @martijn-arns.bsky.social · 21/05/2025

📢 Speaker Highlight: Jonathan Downar Join us in Nijmegen, Netherlands (Sept 30-Oct 2) for his talk: 'From one-session-a-day to TMS-in-a-day: The ONE-D trial' at the Brainclinics TMS Masterclass 🔗 Register today: brainclinics.com/masterclass/...

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Martijn Arns @martijn-arns.bsky.social · 07/05/2025

📢 Speaker Highlight: @andreashorn.org Join us in Nijmegen, Netherlands (Sept 30-Oct 2) for his talk: 'Toward connectomic based neuromodulation' at the Brainclinics TMS Masterclass 🔗 Register today: brainclinics.com/masterclass/...

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Martijn Arns @martijn-arns.bsky.social · 23/04/2025

Great line-up of speakers: Jonathan Downar, @andreashorn.org , Nikita van der Vinne, Joshua Brown

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Martijn Arns @martijn-arns.bsky.social · 23/04/2025

TMS in ONE Day? How to pharmacologically augment TMS response? Toward connectomic based neuromodulation? Heart-Brain Coupling? Learn the latest developments in brain stimulation: Sign-up for the Brainclinics TMS Masterclass and Certification Course: brainclinics.com/masterclass/...

brainclinics.com

Masterclass 2025

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Martijn Arns @martijn-arns.bsky.social · 24/06/2025

📢 Speaker Highlight: Joshua Brown Join us in Nijmegen, Netherlands (Sept 30-Oct 2) for his talk: 'Leveraging the synaptic mechanism of TMS with pharmacological augmentation' at the Brainclinics Foundation TMS Masterclass. Sign-up here: brainclinics.com/masterclass/...

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Martijn Arns @martijn-arns.bsky.social · 18/06/2025

Look forward learning a lot at Psychedelics Science 2025, see you there? #PS2025

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RD PascualMarqui @pascualmarqui.bsky.social · 10/06/2025

Frank, Galinsky, Krigolson, Tapert, Bickel, Martinez: Imaging of brain electric field networks with spatially resolved EEG. eLife. 2025 Jun 5 doi.org/10.7554/eLif... They show: for visual stimulation, from 61 EEG electrodes, the electric field networks in the brain at 1mm resolution. REALLY !!??

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Desmond Oathes, PhD @desmondoathes.bsky.social · 04/06/2025

Talk today (Wed, June 4) on zoom, 1:30pm Eastern. Hope to see you.

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Martijn Arns @martijn-arns.bsky.social · 03/06/2025

Tomorrow Eva Dijkstra will defend her PhD thesis: The Heart-Brain Connection: A pathway to personalized TMS treatment at Maastricht University Congrats Eva Dijkstra with this great achievement and enjoy your day!

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Martijn Arns @martijn-arns.bsky.social · 03/06/2025

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