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Submit a workshop proposal for COSYNE 2026 in Cascais, Portugal. Proposals due October 23, 2025. Explore emerging topics in systems neuroscience.

Conference Abstracts

Models and interventions of cognition.

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

Bilaterian animals must integrate sensory input from both sides of their bodies to make coherent perceptual decisions. In Drosophila larvae, olfactory receptor neurons target the ipsilateral brain hem...

Chiang and Rich show that macaques spontaneously chunk spatial targets in a self-ordered working memory task. dlPFC neurons compress chunked targets into lower-dimensional representations that are shi...

Using a virtual reality system, experiments in Drosophila show that flies use memory mechanisms to navigate along the boundary of an odour plume and track the source of a smell.

People are effort-averse in most situations but can exert effort for little reward when progressing towards goals. Here, the authors show that under deadline pressure people become effort-seeking whil...

Simultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells...

Author summary Computational psychiatry is a field that makes extensive use of computational methods to understand mental health. In this field and related disciplines, there is a strong need to desig...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Sensory processing is dynamically tuned by internal state, yet how metabolic signals reshape the earliest stages of sensory circuits remains poorly understood. Here we identify a circuit mechanism by which satiety suppresses olfactory sensitivity at the first central synapse in the mouse olfactory bulb. Using a within-animal paradigm modelling fasted and glucose-induced sated states, we show that satiety impairs food-finding behaviour and reduces olfactory receptor neuron input to the olfactory bulb. Periglomerular (PG) cells, which co-express insulin receptors and the potassium channel Kv1.3, mediate this effect: insulin inhibits the low-voltage-activated Kv1.3 current in PG cells, increasing their spontaneous and odour-evoked activity. This heightened PG cell activity drives enhanced presynaptic inhibition of olfactory receptor neuron terminals, dampening sensory input before it reaches mitral cells. These findings establish insulin-dependent presynaptic inhibition of PG cells as a key locus of state-dependent sensory gain control. ### Competing Interest Statement The authors have declared no competing interest. Medical Research Council, https://ror.org/03x94j517, MR/V003747/1 Biotechnology and Biological Sciences Research Council, BB/ Z51679X/1

PhD Position in Ultra-High-Field Layer fMRI of Cognitive Control and Interoception

Animals must generalize from limited experience, yet behavioral experiments in the laboratory setting rarely assess whether or how rapidly they generalize. This contrasts with machine learning systems...

Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.

Difficult decisions require gathering evidence over extended periods, placing demands on working memory. Yet, how working memory limitations affect decision-making remains largely unknown. We trained ...

When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...

Humans build internal models from online observations to adapt to new environments. Here, the authors show that individuals are biased towards building models with moderate structural complexity, rega...

Compositionality exists on a continuum of increasing complexity rather than as a binary trait. Studying its implementation in simpler biological and artificial systems is the most tractable path towar...