iiinova — where your digital self keeps evolving

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Nobel Prize @nobelprize.org · 05/10/2026

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

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Florent Waltz @florentwaltz.bsky.social · 05/10/2026

Huge congratulations to all three Nobel Laureates, and especially Peter Hegemann! 👏 His seminal work on the green alga Chlamydomonas 🦠 laid the foundation for optogenetics. Thank you for putting Chlamy in the spotlight! ✨ Proof that groundbreaking discoveries don't always come from animal models! 🔬

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Mark Dolore @queertestimony.bsky.social · 30/09/2026

Today is Canada's Day of Truth and Reconciliation. It is not a day to celebrate. It is a day to listen. A day to recognize the costs of colonialism and capitalism.

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Eric Topol @erictopol.bsky.social · 21/09/2026

How forever chemicals (PFAS) block our immune response to viruses www.pnas.org/doi/full/10....

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Jonathan McDowell @planet4589.bsky.social · 14/09/2026

Apparently the commander of the International Space Station brought her dancing pants to space with her

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Michael Baym @baym.lol · 13/09/2026

Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide

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Itai Yanai @itaiyanai.bsky.social · 31/08/2026

Advice for new PhD students: choose a mentor who is committed to your training, not just your project. The most important product of your PhD - even more important than the science - is YOU, a newly trained scientist.

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Meg Mindlin @invertebabe.bsky.social · 29/07/2026

New research just dropped today that makes octopuses even weirder than they already are… let me explain🧵🧪🐙🐡🦑

OCTOPUSES JUST GOT WEIRDER
Featuring an illustration of a two spot octopus with a blue and purple ribosome behind it

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osn-scott.bsky.social @osn-scott.bsky.social · 27/07/2026

My first computer was the Australian Excalibur 64 Kit computer by BGR Computers sold for AUD$399 using CP/M and MS BASIC. A whopping 64k RAM with a Z80 microprocessor running at 3.5 MHz. It used a cassette backup but later they offered a floppy drive controller. No DOS!

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CosmicRami 🏳️‍🌈🏳️‍⚧️ @rami.spaceaustralia.com · 21/07/2026

🚨TWO YEARS FROM TODAY! 🚨 TOTAL SOLAR ECLIPSE OVER AUS/NZ ☀️🌑🌏 Here's the view 6M+ people in #Sydney will have. Last one here was 1857. Next one here is 2858. It's a once-in-a-thousand-year (totality) event! Are you thinking of coming along to Sydney? A thread of info for you 🧵👇 📸 TimeAndDate

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Sebastian S. Cocioba @atinygreencell.bsky.social · 08/07/2026

@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...

biorxiv.org

OpenEvo: An Open-Source Platform for Automated Evolution and Analysis

Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...

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Sebastian S. Cocioba @atinygreencell.bsky.social · 27/06/2026

I love my lil lab! Sacrificed so much to get here, but I am so damn proud of this research nook that sustains me. The biological equivalent of Carl Sagan's Spaceship of the Imagination. I'm a journeyman helmsman at best, but this little sloop is agile in rough seas.

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Sebastian S. Cocioba @atinygreencell.bsky.social · 29/05/2026

SPLICECRAFT v1.0 IS LIVE!!!!!!!!!!!! Open your terminal and type in "pipx install splicecraft" if you want to try it out, then spam "splicecraft update" often as I push updates frequently. A labor of love for the community I adore. Enjoy! 💚

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Sebastian S. Cocioba @atinygreencell.bsky.social · 24/05/2026

PHEW! The last few days were a MARATHON of vibecoding. Got a TON done, still more to go, but I can safely cancel my SnapGene subscription as of today and replace it with my SpliceCraft software for all cloning and genetic design going forward. Exhaustingly tedious but worth it.

static.klipy.com

Corgi Dog Hacker

ALT: Corgi Dog Hacker

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Sebastian S. Cocioba @atinygreencell.bsky.social · 20/05/2026

Excited to say I'll be releasing version 1.0.0 of SpliceCraft in just 4 days time! It won't be perfect, but I have done as much as I could to bring it to this state and will be open to all criticism on the behavior, utility, errors, etc. Let ego not be the death of good tooling.

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Irina Bezsonova @irinabezsonova.bsky.social · 28/04/2026

Excited to share that my 2025 collection of science-inspired drawings is now live on the Protein Data Bank (PDB) website. Thank you @rcsbpdb.bsky.social! It is free to explore and download. I’d love to hear what you think! pdb101.rcsb.org/sci-art/bezs...

pdb101.rcsb.org

PDB101: Irina Bezsonova Gallery

PDB-101: Training, Outreach, and Education portal of RCSB PDB

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Ben Scott @benmiscott.bsky.social · 30/03/2026

Proud of this work with @osn-scott.bsky.social. We challenge the assumption that DNA should be expensive and hard to access. We provide clear steps to making biology more open for strengthening the bioeconomy. 🧬

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Canadian Journal of Microbiology @canjmicrobio.bsky.social · 03/02/2026

Innovation in biotech is bottlenecked by expensive, restricted DNA parts. A new Open Bio Research Alliance could make DNA building accessible, affordable, and open—boosting Canada’s bioeconomy and biosecurity. #SyntheticBiology #OpenScience #Bioeconomy ow.ly/pNtW50XW8No

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Iván Hidalgo-Cenalmor @ivanhcenalmor.bsky.social · 16/03/2026

Excited to share my first PhD project: LabConstrictor 📒🐍 Have you ever created a Jupyter notebook with all your love 🫶, only for others to be unable to install it 🥲? LabConstrictor, comes to solve this! Check out how it works in the preprint 🔗 arxiv.org/abs/2603.107... or follow this thread ⬇️

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SynBio Canada @synbiocanada.bsky.social · 13/03/2026

🚨JOB ALERTS🚨 @flowgenomics.bsky.social in Toronto is hiring a Laboratory and Operations Manager 🧬 and Dr. Yufeng Zhao (University of Toronto) is hiring a Postdoctoral Researcher focused on advancing Organ-on-a-Chip (OOC) models ❤️‍🩹 www.synbiocanada.org/job-board

synbiocanada.org

Job Board — SynBio Canada

Job Board

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Sebastian S. Cocioba @atinygreencell.bsky.social · 23/02/2026

Plant assembly in OpenCloning soooooon!

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osn-scott.bsky.social @osn-scott.bsky.social · 23/02/2026

I am very much looking forward to SynBio 8.0 in June. I will be speaking on a panel regarding open lab resources and IP -details to follow. It will also be awesome to connect in person with friends back east. This is Canada’s premiere synthetic biology meeting, hosted by U of Waterloo. Go Register!

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osn-scott.bsky.social @osn-scott.bsky.social · 23/02/2026

I've been working with the OpenCloning Assembler with the syntax of my Open Yeast System - both the Open Yeast Collection and Yeast Protein Expression Toolkit. It is a very powerful open approach for rapidly assembling constructs when you have a library of parts. Try it with your Golden Gate system.

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SynBio Canada @synbiocanada.bsky.social · 18/02/2026

Registration now open for SynBio 8.0, June 15-17 at the University of Waterloo. www.synbiocanada.org/synbio8 Join us at Canada’s premier synthetic biology conference, bringing the community together to showcase advances from across the country and across the full breadth of the field! #synbio8 🍁🧬

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Alex Holehouse @alexholehouse.bsky.social · 12/02/2026

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

nature.com

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

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Alliance of Genome Resources @alliancegenome.bsky.social · 19/12/2025

Alliance version 8.3.0 is now live at alliancegenome.org. Release notes are here www.alliancegenome.org/release-notes

alliancegenome.org

Alliance of Genome Resources

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Eryk Salvaggio @eryk.bsky.social · 14/12/2025

It’s good to see papers start to address LLMs as structural plagiarism — provenance, more hidden than the original words or training data. www.nature.com/articles/s42...

nature.com

LLM use in scholarly writing poses a provenance problem

Nature Machine Intelligence - LLM use in scholarly writing poses a provenance problem

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Manuel Lera-Ramirez @manu-lera.bsky.social · 26/11/2025

🚀 A long-requested feature just landed in #OpenCloning 🔬🧬 You can now manually annotate sequences and create primers right from the editor ✨ Hope it makes your workflow a bit smoother! 📨 If you want to stay updated with upcoming features, subscribe to the mailing list (link in the comments)

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osn-scott.bsky.social @osn-scott.bsky.social · 19/11/2025

Here is another paper that gives a lot of background on the IS10 transposon integration and what regulates it. pmc.ncbi.nlm.nih.gov/articles/PMC... What is the e coli strain that you used?

pmc.ncbi.nlm.nih.gov

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osn-scott.bsky.social @osn-scott.bsky.social · 19/11/2025

I see. Is the transposon jumping into the same sequence in your two plasmid examples? There might be clues to help you in PMID: 11683262 and PMID: 8863735 (who's plasmid SCU46780 is in Genbank).

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osn-scott.bsky.social @osn-scott.bsky.social · 19/11/2025

You don't say which tool(s) you are using to create/annotate the plasmid map. Looks like it could be an annotation from pLannotate. If you have your file in the Genbank format, rather than a proprietary one, you can open it and delete any annotation that bugs you.

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

nature.com

Estimation and mapping of the missing heritability of human phenotypes - Nature

WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

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Harmit Singh Malik @harmitmalik.bsky.social · 12/11/2025

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

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David Ho @davidho.bsky.social · 09/11/2025

Better than making Marmite. 😝

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Thiago Carvalho @cyrilpedia.bsky.social · 03/11/2025

'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'

asimov.press

Origins of the Lab Mouse

How the mouse found its way from Victorian novelty to a biomedical mainstay.

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Steven Salzberg @stevensalzberg.bsky.social · 29/10/2025

My former mentor, colleague, and friend Hamilton Smith passed away this week. He was a giant in science, a Nobel Laureate, but also one of the nicest people you could ever meet. He will be missed by many. www.jcvi.org/media-center...

jcvi.org

Remembering Hamilton O. Smith

Hamilton O. Smith August 31, 1931 – October 25, 2025 It is with profound sorrow that we announce the loss of Hamilton O. Smith, M.D., a...

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Asaf Levy @asaflevylab.bsky.social · 26/10/2025

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

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Science Magazine @science.org · 20/10/2025

13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020. On #WorldCRISPRDay, read the landmark paper that describes the discovery: scim.ag/42JHuSN

scim.ag

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

A prokaryotic RNA–directed targeting system can be designed to cleave any DNA sequence.

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osn-scott.bsky.social @osn-scott.bsky.social · 23/09/2025

As a member of the @igemcommunity.bsky.social Engineering Committee I received additional small grants to extend these toolkits both of which are now in over 50 countries around the world. Congratulations to the four other recipients. |5/5|

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osn-scott.bsky.social @osn-scott.bsky.social · 23/09/2025

More recently, @jenny-molloy.bsky.social, through a grant from the University of Cambridge Impact EPSRC Impact Acceleration Account, funded the synthesis of the first round of the Yeast Protein Expression Toolkit. ...4/5

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osn-scott.bsky.social @osn-scott.bsky.social · 23/09/2025

The original OYC is a foundational and enabling framework for contributing to the creation of an open, sustainable and equitable bioeconomy. Synthesis of the original Open Yeast Collection was funded and distributed by @drewendy.bsky.social's BioBricks Foundations FreeGenes program. ...3/5

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osn-scott.bsky.social @osn-scott.bsky.social · 23/09/2025

Yeast Protein Expression Toolkit to permit engineering of the “non-conventional” oleaginous yeast species Yarrowia lipolytica. Imagine one universal toolkit for all of the common industrial and research yeast species. ...2/5

The Yeast Protein Expression Toolkit extend the Open Yeast Collection by offering a library of DNA parts for adding protein fusion tags, including secretion signals, purification tags, linkers, fluorescent proteins and protease cleavages sites.

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osn-scott.bsky.social @osn-scott.bsky.social · 23/09/2025

A big thank you to RootPath and its reviewers on selecting my project for the inaugural #MegabaseSpark competition. 100kbp of free rBlock DNA synthesis is very significant. I am very excited to put this win to good use in extending Open Yeast Collection (OYC) and the ...1/5

The Open Yeast Collection (OYC) is an open DNA toolkit released under the OpenMTA for engineering yeast. It is a library of DNA parts that can be assembled into constructs to produce proteins or develop metabolic pathways in yeast.

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Rayan Chikhi @rayanchikhi.bsky.social · 03/09/2025

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...

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Giulio Ermanno Pibiri @jermp.bsky.social · 28/08/2025

Wow, more than 2.4M of assembled bacteria in the new release of ABT! We plan to index these using our efficient colored De Bruijn graph index, Fulgor. We recently conducted experiments with nearly 1M genomes…getting there :) www.biorxiv.org/content/10.1...

biorxiv.org

AllTheBacteria - all bacterial genomes assembled, available and searchable

The bacterial sequence data publicly available via the global DNA archives is a vast potential source of information on the evolution of bacteria. However, most of this sequence data is unassembled, o...

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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 27/08/2025

Related but cool combo of cytogenetics and phenotype. Know when the first QTL was mapped? Sax, K. 1923. The association of size differences with seed coat pattern and pigmentation in Phaseolus vulgaris. Genetics 8:552-560.

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