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Reposted by Dan J. Hayman

Mirre Simons @mirresimons.bsky.social · 18/07/2025

New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits. www.biorxiv.org/content/10.1...

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Reposted by Dan J. Hayman

Mirre Simons @mirresimons.bsky.social · 24/03/2025

Latest. Dan tested the importance of Drosophila immune cells by ablating or expanding them using conditional genetics. Turns out no lifespan phenotype, perhaps because there is compensation within the immune cell lineage. More exciting biology to discover. journals.biologists.com/jeb/article/...

journals.biologists.com

Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection

Macrophages are responsible for diverse and fundamental functions in vertebrates. Drosophila blood cells (haemocytes) are dominated by cells bearing a striking homology to vertebrate macrophages (plas...

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Dan J. Hayman @danjhayman.bsky.social · 22/11/2024

Really excited to say that from January I'll be starting as an ECR Fellow with the Dunhill Medical Trust based at the University of Sheffield, using Drosophila to look at RNA splicing in ageing! Seems as good a first post on here as I can come up with!

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