How do cells faithfully segregate chromosomes within an optimal time? Using naturally “super-resolved” kinetochores, the authors show that maximal microtubule occupancy prevents bad mitotic memories t...

Immer mehr Frauen bekommen Kinder nur mit immer größeren Schwierigkeiten oder gar nicht. Die Geburtenrate sinkt, Kinderwunschpraxen boomen. Liegt es an Erkrankungen wie Endometriose und PCOS, an Umwel...

Nur jede dritte künstliche Befruchtung hat Erfolg. Melina Schuh weiß, warum. Die Ausnahmewissenschaftlerin hat Bahnbrechendes über Eizellen herausgefunden. Jetzt macht sie aus ihrem Wissen ein Produkt...

Dr. Melina Schuh erforscht, wie menschliche Eizellen funktionieren und worin Ursachen für Unfruchtbarkeit und Fehlgeburten liegen.

Over the last thirteen years, bioRxiv and medRxiv have grown into widely used infrastructure for rapid research sharing in biology and medicine. The reliability and researcher-first values that have d...

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Biochemist Melina Schuh elected Fellow of the Royal Society for groundbreaking research on egg cell development.

Aneuploidy in human eggs, which rises sharply with age, is a leading cause of infertility, IVF failure, and miscarriage. This age-related aneuploidy is primarily driven by premature sister chromatid s...

Exclusive: Research suggests supplementing eggs with a key protein reduces age-related defects, raising hopes of improved IVF for older women

Every day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cel...

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...

Germ cells accurately organize their chromosomes through the program of meiosis to successfully generate haploid gametes for fertilization1. Chromosomal pairing, which is essential for homologous reco...

Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…

Yang et al. use cryo-ET and resolve a unique native architecture of microtubule singlet-to-doublet transition in the basal body of Plasmodium. They reveal the key role of δTubulin and ε-Tubulin in thi...

Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...