Reposted by @qiangguo.bsky.socialDa-Neng Wang @danengw.bsky.social · 28/07/2026Congratulations to Ellen Zhong, Princeton University, for receiving the 2026 K.H. Kuo Award for Outstanding Young Scientist in Structural Biology www.bsc.org.cn/KuoSymposium... 1309
Reposted by @qiangguo.bsky.socialDa-Neng Wang @danengw.bsky.social · 28/07/2026Congratulations to Chris Russo, MRC Laboratory of Molecular Biology, for receiving the 2026 K.H. Kuo Award for Distinguished Scientist in Biological Electron Microscopy www.bsc.org.cn/KuoSymposium... 14812
qiangguo.bsky.social @qiangguo.bsky.social · 24/06/2026Take a look at the fantastic lineup of speakers we have assembled for the 2026 Kuo Symposium in Beijing! The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available. See you in Beijing! www.bsc.org.cn/KuoSymposium... 152
qiangguo.bsky.social @qiangguo.bsky.social · 22/04/20264/ We propose that this conserved architecture reveals a strategy for metabolic compartmentalization that couples efficient catalysis with increased molecular robustness. 011
qiangguo.bsky.social @qiangguo.bsky.social · 22/04/20263/ Structure-guided perturbation abolishes the assembly in vivo without measurably altering intrinsic catalytic activity, suggesting that the main role of the assembly is spatial organization rather than allosteric regulation. 000
qiangguo.bsky.social @qiangguo.bsky.social · 22/04/20262/ Urate oxidase homotetramers assemble into helical fibers that laterally tile into a stable, porous lamellar scaffold. This organization preserves accessible surface area while allowing substrate and product exchange. 000
qiangguo.bsky.social @qiangguo.bsky.social · 22/04/2026Preprint with new server~ Using in situ cryo-ET, we identify a previously uncharacterized higher-order architecture of urate oxidase in mouse liver. langtaosha.org.cn/lts/en/prepr...langtaosha.org.cnA conserved helix-tiling architecture of urate oxidase organizes metabolism in peroxisomesCells organize metabolism within a crowded intracellular milieu, yet the structural logic and functional consequences of supramolecular enzyme assemblies in vivo remain poorly defined. Here, using in 172
qiangguo.bsky.social @qiangguo.bsky.social · 21/04/2026It is exciting to see closely related biology highlighted in a recent Science paper as well, underscoring the importance of this field. science.org/doi/10.1126/...science.orgRibosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomesCells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio... 082
qiangguo.bsky.social @qiangguo.bsky.social · 21/04/2026The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...doi.orgrRNA expansion segments mediate ribosome dimerization as a conserved stress responseAbstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud 0115
qiangguo.bsky.social @qiangguo.bsky.social · 26/02/2026Excited to share what we uncovered using in-tissue cryo-ET in mouse liver: a structural snapshot of lipid droplet biogenesis in situ. Timely reading—particularly after a lipid-rich Chinese New Year😂 The lipid homeostasis story governed by CLCC1 with more details here: www.nature.com/articles/s41...nature.comCLCC1 governs ER bilayer equilibration to maintain lipid homeostasis - NaturePhospholipid scrambling at the endoplasmic reticulum is essential for establishing a dynamic equilibrium to maintain cellular homeostasis. 1164
qiangguo.bsky.social @qiangguo.bsky.social · 23/02/2026Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...biorxiv.org 093
qiangguo.bsky.social @qiangguo.bsky.social · 07/01/2026How do cells trigger an antiviral response so quickly? 🤔 Our new paper proposes an "Intermitochondrial Activation" model. By visualizing MAVS with Cryo-ET, we saw that activated mitochondria use MAVS fibrils to "fish" for dormant mitochondria, spreading the alarm signal fast. doi.org/10.1038/s414...nature.comPrion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response - Cellular & Molecular ImmunologyCellular & Molecular Immunology - Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response 142
Reposted by @qiangguo.bsky.socialjoe dobbs @joedobbs.bsky.social · 25/12/2025Really excellent work by the bluesky-less Marie and Sara +coauthors in our lab @embl.org! Check it out for cool combinations of light microscopy and #cryoET, and if you're interested in how yeasts reorganize structurally in response to stressors. #teamtomo 0298
qiangguo.bsky.social @qiangguo.bsky.social · 16/10/2025We usually learn that centrioles/basal bodies are made of microtubule triplets. But our work on Plasmodium shows its basal body is built from singlets, which then mature into the doublets of a functional cilium. #TEAMTOMO www.nature.com/articles/s41...nature.comA basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis - Nature CommunicationsYang et al. use cryo-ET and resolve a unique native architecture of microtubule singlet-to-doublet transition in the basal body of Plasmodium. They reveal the key role of δTubulin and ε-Tubulin in thi... 2127
qiangguo.bsky.social @qiangguo.bsky.social · 05/10/2025What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...science.orgTranslation landscape of stress granulesCryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery. 0115
qiangguo.bsky.social @qiangguo.bsky.social · 24/09/2025Wow, nice story~ This interaction is suprising for me~ Back 2018, after the HTT-HAP40 story, we screened a lot of interactiors of HTT, and none of them really stable enough for structural study. We should try these filamental structuctures as well😀 020
