This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…

How do cells faithfully segregate chromosomes within an optimal time? Using naturally “super-resolved” kinetochores, the authors show that maximal microtubule occupancy prevents bad mitotic memories t...

The Dudka Lab at Lehigh University studies how rapid evolution of chromosome segregation machinery impacts health, fertility, and disease.

Microtubules are essential cytoskeleton polymers composed of α/β-tubulin heterodimers that play a central role in the regulation of various cellular processes, including cell division, cell shape, cel...

Nature Communications - Almeida AC et al. uncover the physiological role of a long-elusive feedback pathway that regulates tubulin biosynthesis. By tuning microtubule dynamics, this mechanism...

Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigg...

Nature Communications - Tubulin conservation presents a challenge to understanding microtubules’ diverse functions in eukaryotes. Here, the authors characterize the structures of P....

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...

Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...

Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

Nature Cell Biology - Dense crowding of macromolecules in the cytoplasm is a fundamental property of cells. A study now identifies a pathway by which cytoplasmic dilution in differentiating neurons...

Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...

Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.

At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle

Chromosome congression to the spindle equator, which recurrently fails in cancer cells leading to an

Accurate chromosome segregation requires sister kinetochores to biorient, attaching to opposite spin