Implements spatial null models and coordinate-space transformations for statistical comparison of brain maps, following the framework described in Markello et al. (2022)…

INTRODUCTION With anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compare.....

Project to maintain a database for CV/website rendering - poldrack/academicdb

Clinical trials for Alzheimer's disease (AD) must be registered on clinicaltrials.gov. The registry presents a variety of types of information related to the planned clinical trial. We assess clinic...

Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In …

This cohort study investigates if the clinical phenotype of patients without dementia is associated with blood phosphorylated tau 217 interpretation.

Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent...

Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...

Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles ...

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Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters to connected brain regions in Alzheimer’s disease.

imageimageThis study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy. ...

De Bruin et al. report that traumatic brain injury does not inherently elevate the Alzheimer’s pathologies amyloid-β or tau, but is associated with their u

This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...