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Carolyn Fredericks

@carolynfredericks.bsky.social
268 followers 342 following 11 posts

Asst Prof of Neurology at Yale. Our lab studies vulnerability & heterogeneity in neurodegeneration (esp AD & asyn) with an emphasis on multimodal neuroimaging. Mom to two little boys and one big dog. Baker, backpacker, devourer of books.

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Carolyn Fredericks @carolynfredericks.bsky.social · 19/06/2026
Currently recruiting for our study of #perimenopause! We want to model how the dynamic hormone shifts of this period impact brain circuitry and, potentially, put a subset of women at greater risk of #alzheimers disease. This project funded by @yalebiomedimaging.bsky.social @whryale.bsky.social.
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Colette Delawalla, PhD @cdelawalla.bsky.social · 29/05/2026
🚨The OMB rule will be the end of science as we know it. MARK YOU CALENDAR for the @standupforscience.net EMERGENCY SCIENCE MEETING June 2nd, 4pm et. We will be giving an overview & assigning EVERY SCIENTIST IN AMERICA their marching orders. REGISTER: events.standupforscience.net/stand-up-for...
events.standupforscience.net
Emergency Science Meeting by Stand Up for Science
[discussing OMB-2026-0034?]
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samuel mehr @mehr.nz · 17/03/2026
new review paper in press, on a brand-new line of research that's personal for me and that I'm excited about — music in Alzheimer's disease and other dementias this one led by a wonderful student Sophia Moret and in collab with my kickass Yale Neurology colleague @carolynfredericks.bsky.social
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 28/07/2025
this ends with a description of what YOU can do. Please get involved now. Everyone can take one of these actions.
you are a lab head, this affects you; if you are a student, this
threatens your future The NIH grant system was already hyper- competitive before Trump. This policy will make it brutal. Without immediate resistance from the research community, this policy will go forward with devastating consequences for
US science.
What can you do? • Contact your Congressional representatives. It is best to show up in person. Explain and tell them to oppose this forward funding mandate. Share this article if it helps! Tell them to protect NIH
funding. • For researchers: Make noise within your institution. Ask your research office what they re doing to push back. Talk to your
program officers. Demand transparency. • Tell your local press that Trump is destroying US medical research, and find
local activist groups to reach out to. • There are many engaged citizens across the country affected by cancer, or Alzheimer's, that want more information from scientists to help them advocate to
their elected officials and to the press.
Offer to talk to them, and help them do
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Rod Rahimi @rodrahimi.bsky.social · 29/07/2025
“The Senate Committee on Appropriations is scheduled to release its proposal for NIH’s 2026 budget later this week…The committee could include language that would prohibit the multiyear funding plan or extend the timeline for the transition.”🧪
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Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · 17/07/2025
What a damn shame. And let's be clear: this rescissions package was merely a test. A start. 🧪 Science folks: Expect a similar bill coming soon for codifying cuts to this year's budget for NSF, NIH, etc. 🧵 Brief thread 1/3
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Carolyn Fredericks @carolynfredericks.bsky.social · 16/07/2025
Hamid Abuwarda's paper showing that we can use the functional connectome to predict focal tau binding in preclinical Alzheimer's disease is out today! academic.oup.com/braincomms/a...
academic.oup.com
Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease
Abuwarda et al. demonstrate that whole brain functional connectivity predicts regional tau tracer binding in preclinical Alzheimer's disease. Their models
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Jeremy Berg @jeremymberg.bsky.social · 30/06/2025
Great interview with Jenna Norton, one of the authors of the #BethesdaDeclaration about its origins and future art19.com/shows/federa... While you are here, sign the support letter (if you haven't already) and share this link. act.standupforscience.net/forms/add-na...
act.standupforscience.net
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
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Jeremy Berg @jeremymberg.bsky.social · 01/07/2025
We miss you, Ben
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Jeremy Berg @jeremymberg.bsky.social · 01/07/2025
Now is a good time to sign on in support of the courageous folks at EPA who stood up for all of us. www.standupforscience.net/epa-declarat...
standupforscience.net
Support EPA Staff Now! — STAND UP FOR SCIENCE
Your solidarity with the EPA heroes increases the pressure on their Administrator Lee Zeldin.
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Jeremy Berg @jeremymberg.bsky.social · 01/07/2025
@repbarragan.bsky.social Thank you so much for your forceful questioning (www.themirror.com/news/us-news... ) of RFK, Jr. It appears that many Alzheimer's Disease Research Center grants are now funded about months of delay. #CallingThemOutMatters
themirror.com
RFK called out over Alzheimer's move in tense exchange with Congresswoman
Rep. Nanette Barragán called out Robert F. Kennedy Jr. following cuts to Alzheimer's research, but the Secretary of the Department of Health and Human Services wasn't aware of them
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 01/07/2025
It’s fine to call Collins or Murkowski. But it is much much much much much more impactful if you can get on local TV in their states and call them to vote against. And if you can’t do that, make a social media video. Communicating to their constituents he is better than calling them.
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Jessica Sommerville @jessicas.bsky.social · 26/06/2025
🚨 Postdoc Opportunity!!! The Toronto Early Cognition Lab (@UofT) is hiring a postdoc to study early optimism in infants & young children. Work w/ multi-method approach, amazing undergrads & grads. Start: Fall 2025 or later. Details: jessica.sommerville@utoronto.ca RTs appreciated 💫
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American Association for the Advancement of Science @aaas.org · 30/04/2025
Earlier today, AAAS CEO Sudip Parikh testified as a bipartisan witness before the U.S. Senate Appropriations Committee, warning that without immediate action, the U.S. runs the risk of losing its position as a global leader in biomedical research and innovation.
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Don Moynihan @donmoyn.bsky.social · 25/04/2025
"President Donald Trump says he wants to reduce our trade deficit. Yet he’s destroying one of our winningest exports: higher education" www.washingtonpost.com/opinions/202...
graph showing that higher ed experts are worth more than gas and coal exports combined
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Mike Greicius @mikegreicius.bsky.social · 18/04/2025
🧪Trump wants to cut NIH spending by 40%. If enacted, this will drive a massive, generational brain 🧠 drain of talented scientists and physician-scientists out of the US. Congress still controls the budget (for now). Call your reps and senators: (202) 224-3121 www.statnews.com/2025/04/16/t...
statnews.com
Trump budget draft proposes NIH consolidation and 40% spending cut
Draft Trump budget proposes a $20 billion NIH budget cut in 2026 and a sweeping consolidation
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Pam Herd @pamherd.bsky.social · 24/04/2025
An update to show the seismic crash in NIH funding. The left side shows NIH has issued almost no "new" awards since Trump took office. Even renewals (you receive a 5 year award, but each year they renew it), which should be mushed into the lines above it, is shockingly low.
Figures showing NIH funding over time on new and renewals grants.  We've basically never seen funding this low (and by a large amount)
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Megan Zahneis @mzahneis.bsky.social · 24/04/2025
As of this morning, the @aacu.org statement opposing the Trump admin's "unprecedented government overreach" has been signed by more than 400 #HigherEd leaders.
aacu.org
A Call for Constructive Engagement | AAC&U
A Call for Constructive Engagement
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Jeremy Berg @jeremymberg.bsky.social · 23/04/2025
The notice and COMMENT PERIOD OPENED TODAY AND CLOSES MAY 23. Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top: www.federalregister.gov/documents/20... 6/n
federalregister.gov
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
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Jeremy Berg @jeremymberg.bsky.social · 23/04/2025
ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
media.tenor.com
the word alert is in a purple circle
ALT: the word alert is in a purple circle
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Mike Greicius @mikegreicius.bsky.social · 24/04/2025
🧪 www.statnews.com/2025/04/23/n... The beginning, I presume, of the Trump Administration's attempt to force journals to accept some number of alternative-view "research" articles on topics like vaccines causing autism or IV bleach injections to treat Covid (as suggested by our president in 2021).
statnews.com
New England Journal of Medicine gets swept up in U.S. attorney inquiry into alleged bias
Last week, at least one scientific journal received a letter from a top U.S. attorney asking it to respond to alleged bias. Now, NEJM has received a similar inquiry as well.
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Jeremy Berg @jeremymberg.bsky.social · 24/04/2025
Updating dashboard this morning with new funding curves, the Barron's article (in Miscellaneous), and Excel files with the latest terminated grants (from the HHS TAGGS site). Looking at the latest terminated grants list was "interesting"... jeremymberg.github.io/jeremyberg.g... 1/n
jeremymberg.github.io
NIH_since_1_20_25
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 24/04/2025
Really good point. These are cuts to research into cures for cancer and Alzheimer’s. And Trump is doing them to corrupt universities and end free speech and free thought. They want to force in conservative ideas that have lost in a free marketplace, and use cancer money to do that
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The Atlantic @theatlantic.com · 24/04/2025
The Trump administration is "willing to not just slash and burn research that challenges their political ideology but to replace it with shoddy studies designed to support their goals, under the guise of scientific legitimacy," Katherine J. Wu writes.
bit.ly
‘This Is Not How We Do Science, Ever’
The Trump administration is manipulating government-sponsored research to get the answers it wants.
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Jeremy Berg @jeremymberg.bsky.social · 08/04/2025
More, or should I say, less pain at NIH... Dismemberment of the Office of Pain Policy and Planning office www.statnews.com/2025/04/08/n...
statnews.com
Unique pain research office eliminated in HHS purge
Pain is the most costly chronic health problem in the U.S. In latest RIFs at NIH, an entire division devoted to pain research was closed down.
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Miriam Goldstein @miriamgoldstein.bsky.social · 08/04/2025
There is a reason that private industry hires communications and government relations professionals. Want to make impactful change? Use every tool at your disposal, or partner with people/orgs who have these skills. I promise you every mid-level trade association is doing the same.
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Doctors for America @drsforamerica.bsky.social · 08/04/2025
Firings at Federal Health Agencies Decimate Offices That Release Public Records “What we need to be doing is the opposite of what’s happening now: hiring more staff.” kffhealthnews.org/news/article...
kffhealthnews.org
Firings at Federal Health Agencies Decimate Offices That Release Public Records - KFF Health News
The Department of Health and Human Services’ mass firings included people who fulfill Freedom of Information Act requests for the Centers for Disease Control and Prevention, National Institutes of Hea...
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Lauren Atlas @laurenatlas.bsky.social · 07/04/2025
We have slots for 2-3 postbacs! Get in touch if you’re interested in joining the Affective Neuroscience and Pain lab & contributing to our studies of pain, emotion, and social processing in the 🧠
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Jeremy Berg @jeremymberg.bsky.social · 08/04/2025
DOGE-induced delays in trials at the NIH Clinical Center (Dr. Steve) Rosenberg said. “Right now, assuming things don’t get any worse, it would be a month [delay]. These are not patients that have very many months left.” This seemed inevitable but is still a big deal... wapo.st/4j8Hwd1 (Gift link)
wapo.st
NIH scientists have a cancer breakthrough. Layoffs are delaying it.
A big step forward in cancer therapy has been slowed by layoffs and new restrictions at the National Institutes of Health, where it was developed.
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Doctors for America @drsforamerica.bsky.social · 07/04/2025
Happy World Health Day! Doctors for America pledges to continue our mission of educating and empowering doctors and healthcare advocates to lead initiatives that improve the health of patients, communities, and the nation.
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Nature @nature.com · 07/04/2025
Long COVID advocates and researchers in the United States have done the extraordinary. After a bruising battle, they managed to revive some of the research grants cancelled by the administration of President Donald Trump. go.nature.com/3RKg5tP
go.nature.com
Long COVID activists fought Trump team’s research cuts and won ― for now
Success gives hope to scientists and advocates who managed to get millions of dollars in grants restored.
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Miriam Goldstein @miriamgoldstein.bsky.social · 07/04/2025
Every member of Congress, across every party, must hold this Admin accountable against advancing the reckless proposals in Project 2025. TY @naturalresources.bsky.social for defending our communities and economies. 👏
flickr.com
HNR_NOAAForum-14
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 02/04/2025
Trump and Musk are trying to block all NIH spending. Trump and Musk are trying to block all NIH spending. (Legal aside: so they’re admitting that regulations matter. That’s good.)
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Jeremy Berg @jeremymberg.bsky.social · 02/04/2025
I don't know what is happening at the NIH Clinical Center. Anyone with insights please reach out here or on Signal (jeremymberg.78). 3/n
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Jeremy Berg @jeremymberg.bsky.social · 02/04/2025
Communications will apparently be consolidated within HHS, but now institutes appear to have better one and zero staff in their communications offices. Procurement staff are mostly gone so that intramural research is likely to be hobbled if not completely disabled. 2/n
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Jeremy Berg @jeremymberg.bsky.social · 02/04/2025
Collecting my thoughts at the end of one of the worst days of my life... At NIH, > 1300 people were RIFed. These range all across the board from institute directors to low level administrative staff. Communication staff and procurement appear to be hardest hit as anticipated from the HHS plan 1/n
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James Medlock @jdcmedlock.bsky.social · 01/04/2025
How it started // how it's going
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Nature @nature.com · 01/04/2025
On health economist Jay Bhattacharya’s first day as head of the US National Institutes of Health (NIH), the chiefs of four of the 27 institutes and centres that make up his agency were removed from their posts. go.nature.com/3QZ8GGT
go.nature.com
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
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Lynn ❌👑 @tnblue.bsky.social · 01/04/2025
Trump Administration Live Updates: Mass Layoffs of Federal Health Workers Begin. These layoffs will kill people. Literally. #donaldtrumpidthis #DemocracyNotDictatorship #StopProject2025
nytimes.com
Trump Live Updates: Tariffs News, Federal Layoffs and More
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 01/04/2025
Thanks, @corybooker.com. bsky.app/profile/food...
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Chris Gunter 🧬 @girlscientist.bsky.social · 01/04/2025
People let go everywhere you turn at NIH today, carrying in empty boxes. Both the people in the elevator with me. Multiple IC directors. The HR people who are supposed to process all the early retirements. All of the people who respond to data calls that we are legally required to answer.
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Darren Incorvaia @megadarren.bsky.social · 01/04/2025
If you're a scientist at the NIH or another HHS agency who was affected by today's RIF, I'd love to hear about the work you were doing and how important it was for our nation's health! I'm a staff writer at Fierce Biotech, and I can be reached through DM on BlueSky or securely on Signal at dinc.49
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Mormino Lab @morminolab.bsky.social · 01/04/2025
Big congrats to Dr. Kyan Younes, for his recent publication in Alzheimer's and Dementia. Here we show that amyloid PET positivity predicts decline in participants enrolled throughout the national Alzheimer's Disease Research Center Program. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort
INTRODUCTION Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated. ...
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Thanh Neville, MD, MSHS @thanh-neville.bsky.social · 01/04/2025
I am so tired of being angry all the time.
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Scott Delaney @scott-delaney.bsky.social · 28/03/2025
PLEASE KEEP SUBMITTING YOUR TERMINATED GRANTS! So far, there have been fewer grants terminated this week than last, but the week ain't over. It's *CRITICAL* to advocacy for the public to know what's going on. We can't do that without you. Submit your terminated grant info here ⤵️
forms.gle
Cancelled NIH grant information submission form
Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025. Data from this form will be used to update the Rescinded NIH...
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Jeremy Berg @jeremymberg.bsky.social · 28/03/2025
Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n
wapo.st
Trump promised scientific breakthroughs. Researchers say he’s breaking science.
NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.
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Carolyn Fredericks @carolynfredericks.bsky.social · 28/03/2025
We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral... Please share with your circles!
The Fredericks Lab! - with deliberately poor photoshopping of lab members who couldn't be there that day.
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Josh Marshall @joshtpm.bsky.social · 28/03/2025
Are you that discontented DOGE staffer? It might be time. You can reach out to me on Signal at joshtpm.99 (I'm not like Mike Waltz; I know how to use it.) You can also get me at joshtpm at protonmail dot com. Are you a federal worker with information I need to hear? I want to hear from you too.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 28/03/2025
NIH’ers and all HHS people: Remember, if they put you on admin leave today that’s not a firing, not until a legal RIF is completed. We are going to fight this.
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Mike Greicius @mikegreicius.bsky.social · 28/03/2025
🧪If I were a non-scientist, vaccine skeptic running the nation's public health system and saw that Texas reached 327 confirmed measles cases this week my first thought would be "I should cut 10,000 full-time positions at Health and Human Services." #publichealth www.texastribune.org/2025/03/26/t...
texastribune.org
Health officials say federal cuts will hurt Texas’ measles response
Federal grants paid for workers to help with measles testing and vaccination in Lubbock and were going to help equip a Dallas lab to test for pathogens, including measles.
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