See paper by @misicbata.bsky.social
This indirectly relates to our current understanding of pain. Network-level integration is necessary for proper pain processing. An anesthetized organism does not respond to noxious input.
www.nature.com/articles/s41...
nature.com
Comprehensive profiling of brain dynamics during anesthesia across phylogeny - Nature Neuroscience
In this study, Luppi et al. systematically characterized and modeled more than 6,000 features of neural activity during anesthesia. They reveal a shared but reversible dynamical endpoint of anesthesia...