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Isaac Wong

@isaacsiuwong.bsky.social
146 followers 145 following 2 posts

Cell Biologist

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Reposted by Isaac Wong
Stella Hurtley @smhsci.bsky.social · 15/09/2026
Come join the editors @science.org to look after papers in Next Generation Medicine jobs.sciencecareers.org/job/679983/a...
jobs.sciencecareers.org
Associate or Senior Editor, Next Generation Medicine - Washington D.C. Washington, DC 20005, USA Cambridge, UK Washington, DC 20005, USA Remote Washington, DC 20005, USA job with American Association ...
Join the editorial team at Science! We are seeking a full time Associate or Senior editor.
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Reposted by Isaac Wong
Raff Lab @jrafflab.bsky.social · 31/07/2026
New in @embojournal.org: Polo/PLK1 phosphorylation relieves Cnn autoinhibition to drive centrosome scaffold assembly. Human CDK5RAP2 appears to share the fly-like mechanism.
link.springer.com
Polo/PLK1 phosphorylation relieves Centrosomin/Cnn autoinhibition to promote centrosome scaffold assembly - The EMBO Journal
Mitotic centrosome maturation requires Polo/PLK1-dependent expansion of the pericentriolar material (PCM). In Drosophila, Centrosomin (Cnn) assembles a scaffold around mitotic centrioles through inter...
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Reposted by Isaac Wong
Stephen Royle @steveroyle.bsky.social · 16/12/2025
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...
biorxiv.org
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
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Isaac Wong @isaacsiuwong.bsky.social · 05/10/2025
Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶‍♂️'s CDK5RAP2.
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Reposted by Isaac Wong
Pombo-GarciaLab @pombo-garcialab.bsky.social · 08/08/2025
🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab Deadline 31 August www.nature.com/naturecareer...
nature.com
Postdoctoral Researcher in Quantitative Cell Biology/Biochemistry (10374) - Harwell, Didcot job with The Rosalind Franklin Institute | 12841894
The Rosalind Franklin Institute (the Franklin) is a technology institute for life science, creating innovative technologies that transform our unde...
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Reposted by Isaac Wong
Shivani Dharmadhikari @sdharmadhikari.bsky.social · 07/08/2025
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
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Isaac Wong @isaacsiuwong.bsky.social · 08/02/2025
Exciting news! Our latest paper reveals that Spd-2 (CEP192) recruits Polo & Aurora A to build two scaffolds—Polo-dependent Cnn (for strength) & Aurora A–dependent TACC (for protein concentration)—crucial for centrosome assembly in Drosophila. #CellBiology #Centrosome www.science.org/doi/10.1126/...
science.org
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
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