The 7th symposium Current Topics in Myelin Research will take place 25-27 February 2027 in Kassel-Wilhelmshöhe (Germany). Purpose of the meeting This symposium brings together scientists interested in...

This study identifies oligodendrocytes as active contributors to cognitive decline in aging, by leveraging a unique human brain bank with more than 70 years of associated cognitive data combined with experimental modeling of oligodendrocyte dysfunction.

Metabolic determinants of white matter integrity remain elusive. Here, the authors show downregulation of MCT2 in oligodendrocytes in progressive MS, and then demonstrate its role in myelin maintenanc...

Axons require intracellular transport of cargoes between the soma and the terminus. The authors show a related logistical challenge exists at smaller scale with respect to the interaction of process-b...

Dr. Yannick Poitelon is an associate professor at Albany Medical College in Albany, NY. He is speaking in the Myelinating Glia in Disorders of Development and Childhood, which runs from 𝟲-𝟴 𝗣𝗠 𝗼𝗻 𝗪𝗲𝗱𝗻...

The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-Co...

A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.

We seek candidates using innovative approaches to address impactful scientific questions related to Parkinson’s disease...

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...

Posted 7:52:14 PM. Department/Unit:Neuroscience & Experimental TherapeuticWork Shift:Day (United States of…See this and similar jobs on LinkedIn.

Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …

The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

What happens when scientists flip a hidden switch inside nerve cells? A CMTA-funded $281,339 study is testing whether this discovery could finally bring new ...

Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

Oligodendrocyte maturation is governed by an SOX6-dependent gene-melted chromatin state at multiple immaturity loci. Reducing SOX6 accelerates maturation, offering a potential strategy to regenerate myelin in diseases like multiple sclerosis.

Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...

The homeostasis of myelin in the central nervous system is highly regulated, but the underlying mechanisms are unclear. Here, the authors show that the FBXW7 protein has a role in constraining myelin ...

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...