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Sophie Siems

@sophiesiems.bsky.social
50 followers 72 following 3 posts

Postdoc @University of Edinburgh | PhD @MPI-NAT Göttingen

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Reposted by Sophie Siems
Hauke Werner @myelincentric.bsky.social · 24/09/2026
Hi Myelinologists, the 7th symposium Current Topics in #Myelin Research will take place 25-27 February 2027 in Kassel (Germany). For topics, confirmed speakers, more info, and registration, check out events.gwdg.de/e/CTMR. Registration closes 11 October 2026.
events.gwdg.de
Current Topics in Myelin Research
The 7th symposium Current Topics in Myelin Research will take place 25-27 February 2027 in Kassel-Wilhelmshöhe (Germany). Purpose of the meeting This symposium brings together scientists interested in...
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Reposted by Sophie Siems
Rafael Almeida @handle.invalid · 25/07/2026
New preprint from the lab 🥳 We made new knock-in zebrafish 🐟 that fluorescently tag endogenous neurofascins. So now, we can live-image neuronal nfasca/NF186 and glial nfascb/NF155 non-invasively, as nerves, nodes of Ranvier and paranodes develop in vivo 🧵👇 www.biorxiv.org/content/10.6...
biorxiv.org
Live-imaging of endogenous neurofascins reveals glial adhesion shapes developing nodes of Ranvier
The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...
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Reposted by Sophie Siems
MariaEichelVogel.bsky.social @mariaeichelvogel.bsky.social · 19/07/2026
Excited to share my postdoc paper from the @lyons-lab.bsky.social Our question: what controls axon diameter? It varies >100-fold between neurons, shapes signal speed & myelination, and changes in disease. Yet very little is known about what regulates it. 🧵 journals.plos.org/plosbiology/...
journals.plos.org
A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish
Axon diameter is important for action potential conduction speed, but what molecular pathways influence this neuronal property? This study reports a high-resolution imaging-based chemical screening pi...
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Sophie Siems @sophiesiems.bsky.social · 20/04/2026
This week marks MS Awareness Week — a time to raise understanding and support for those living with MS. To do my part, I’ll be running the Edinburgh Half Marathon to fundraise for the UK MS Society. If you’d like to support, I’d be incredibly grateful. 🧡 www.justgiving.com/fundraising/...
justgiving.com
Sophie is running 2026 Edinburgh Half Marathon for MS Society
Help Sophie Siems raise money to support Multiple Sclerosis Society
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Sophie Siems @sophiesiems.bsky.social · 15/12/2025
Pleased to share that I’ve been awarded a Catalyst Award from the @mssocietyuk.bsky.social 🥳 Many thanks to the MS Society UK for supporting our research in the @almeidalab.bsky.social and helping to advance understanding of MS!
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Reposted by Sophie Siems
Hauke Werner @myelincentric.bsky.social · 03/09/2025
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed! www.biorxiv.org/content/10.1...
biorxiv.org
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...
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Reposted by Sophie Siems
Rafael Almeida @handle.invalid · 15/08/2025
Thrilled that myelin purifier extraordinaire @sophiesiems.bsky.social bagged a DFG fellowship from the Walter Benjamin Program to study axon-myelin adhesion dynamics in zebrafish! Congrats Sophie, and thanks DFG ☺️
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