barakboaz.bsky.social @barakboaz.bsky.social · 05/09/2026Excited to share our new Comment in Nature Reviews Disease Primers! We discuss how incorporating experiential knowledge from patients and caregivers early in basic research can reveal hidden disease features and guide smarter biological hypotheses. 100
barakboaz.bsky.social @barakboaz.bsky.social · 27/09/2025🚀 Our new paper is out in Nature Communications! We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination. Open access link: www.nature.com/articles/s41...nature.comGtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements - Nature CommunicationsThe transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction. 3144
barakboaz.bsky.social @barakboaz.bsky.social · 03/04/2025Another great work from the Bergles group. Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan | Nature Aging www.nature.com/articles/s43...nature.comTranscriptional profiles of mouse oligodendrocyte precursor cells across the lifespan - Nature AgingA single-cell transcriptomic profile of oligodendrocyte precursor cells in the brain across the mouse lifespan reveals aging-associated changes that contribute to the decline of oligodendrogenesis in ... 010
Reposted by @barakboaz.bsky.socialEthan Hughes @ethanhugheslab.bsky.social · 23/12/2024Cool work on the effects of OPC specific deletion of glucocorticoid receptors! Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior www.biorxiv.org/content/10.1...biorxiv.orgGlucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behaviorEarly life events shape neuronal networks, and prime juvenile and adult behavior. Severely aversive, early experiences can interfere with brain development and enhance the risk for the onset of psychi... 0154
Reposted by @barakboaz.bsky.socialItai Yanai @itaiyanai.bsky.social · 28/11/2024If you submit your grants last minute, you're in good company. For the 2005 NIH Pioneer grant, half of the applications were submitted in the last two days. The red bars indicate the awardees. One awardee submitted 8 minutes before the deadline. bsky.app/profile/jere... @jeremymberg.bsky.social 98720
