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Stephen McLaughlin

@lmbbiophysics.bsky.social
462 followers 579 following 19 posts

Biophysics@MRC Laboratory Molecular Biology, Cambridge All opinions are my own

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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 02/10/2026
Considering a PhD in 2027? Applications for Gates Cambridge Scholarships @gatescambridge.bsky.social are now open for October 2027 PhD entry (deadline: 14 October 2026). Learn more about PhD study at the LMB: mrclmb.ac.uk/careers-and-...
mrclmb.ac.uk
PhD Students | MRC Laboratory of Molecular Biology
PhD Students Budding scientists from all over the world undertake postgraduate research at the LMB. Our students are creative and innovative, driving the su ...
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Reposted by Stephen McLaughlin
Nature @nature.com · 01/10/2026
Structural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau. go.nature.com/4yoegqh
go.nature.com
Harmful tau spreads like self-propagating prion proteins
Structural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau.
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Reposted by Stephen McLaughlin
Kai Yi @kaiyi94.bsky.social · 29/09/2026
1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: α-synuclein, RBX1 and active-state GPCR nanobodies.
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Stephen McLaughlin @lmbbiophysics.bsky.social · 15/09/2026
Looking forward to welcoming all the in person and virtual attendees @mrclmb.ac.uk for our 10th Next Generation Biophysics Symposium tomorrow #NGBS2026
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Stephen McLaughlin @lmbbiophysics.bsky.social · 15/09/2026
What an opportunity!
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Stephen McLaughlin @lmbbiophysics.bsky.social · 08/09/2026
Registration is closing tomorrow, 9th September, for our 10th Next Generation Biophysics Symposium. Join us either in-person or on-line by clicking here: www3.mrc-lmb.cam.ac.uk/sites/nextge...
A card with information on the Next Generation Biophysics Symposium on 16th September 2026 at the LMB. Registration is closing 9th September. A QR code link to registration website.
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Reposted by Stephen McLaughlin
Lara Krüger @lara-kruger.bsky.social · 09/06/2026
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
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Reposted by Stephen McLaughlin
Traffic @traffic-journal.bsky.social · 28/08/2026
Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/08/2026
📣 Just 2 weeks left to register for the tenth anniversary Next Generation Biophysics Symposium. Join us at the LMB on 16 September to hear a range of speakers cover how they're using new & emerging biophysical techniques. Register by 9 September ➡️ www3.mrc-lmb.cam.ac.uk/sites/nextge…
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Reposted by Stephen McLaughlin
Sholto David @sholtodavid.bsky.social · 25/08/2026
Today I'm posting a new blog! Nearly two hundred papers have muddled the names for different proteins and recorded using the wrong antibody for a range of experiments. This time it's PERK vs. p-ERK. Including researchers from Harvard, the Mayo Clinic, and more. sholto.substack.com/p/perk-vs-p-...
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 22/07/2026
In brain development, timing is everything. @sebastiancachero.bsky.social @erikadona.bsky.social & @jefferis.bsky.social have mapped 450,000+ cells from developing fly nervous systems to build an expansive atlas, revealing how neurons 'remember' when they were born. shorturl.at/tfI4s #LMBResearch🧪
Heatmap shows temporal expression of 17 transcription factors across neuron birth orders, with a UMAP plot visualising cell identity relationships.
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/07/2026
Thousands of possible receptor-peptide combinations. One AI-powered solution. Led by @lariferg.bsky.social, a study from @schaferlab.bsky.social & Isabel Beets has developed DeorphaNN, a neural network to identify peptide pairings for GPCRs. Read more: mrclmb.ac.uk/news-events/... #LMBResearch
Protein structure prediction confidence for a specific region is improved when an active-state template is used.
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Stephen McLaughlin @lmbbiophysics.bsky.social · 29/06/2026
It will be our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk on 16th September. Please join us in person or online and celebrate all things #biophysics www3.mrc-lmb.cam.ac.uk/sites/nextge...
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Reposted by Stephen McLaughlin
Pablo Alcón @palconh.bsky.social · 23/06/2026
Join us! Postdoc position (2-3 years) in our lab @molbiolau.bsky.social Looking for candidates with experience in cell culture, genome editing, biochemistry, and/or structural biology. Application opens in August via AU's system but informal enquiries by email are welcome from now. (1/2)
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Reposted by Stephen McLaughlin
Molecular Cell @cp-molcell.bsky.social · 04/06/2026
Online Now: TRIM21 induces selective autophagy of viruses and bacteria Online now:
dlvr.it
TRIM21 induces selective autophagy of viruses and bacteria
Rhinesmith et al. describe an intracellular antimicrobial mechanism called “antibody-directed xenophagy” (ADX). In ADX, the E3 ubiquitin ligase TRIM21 prevents infection by intercepting antibody-coated viruses/bacteria in the cytosol and orchestrating their destruction via selective autophagy. The authors hypothesize that ADX may be co-opted for targeted protein degradation.
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Reposted by Stephen McLaughlin
Sholto David @sholtodavid.bsky.social · 02/06/2026
Today I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a totally wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins. forbetterscience.com/2026/06/02/m...
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Reposted by Stephen McLaughlin
Sholto David @sholtodavid.bsky.social · 28/05/2026
Reluctant to post too much about this but I did want to share my favourite finding from the dozens of manipulated or duplicated ThermoFisher verification blots. This one has a giant square. Enjoy!
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Stephen McLaughlin @lmbbiophysics.bsky.social · 05/05/2026
Hope you can join us for our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk in September. We have a fantastic speaker line up: www3.mrc-lmb.cam.ac.uk/sites/nextge...
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Reposted by Stephen McLaughlin
Simon Bullock @simonbullock11.bsky.social · 05/05/2026
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
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Reposted by Stephen McLaughlin
Carter Lab @carter-lab.bsky.social · 29/04/2026
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social. Available now on BioRxiv: doi.org/10.64898/202...
doi.org
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Reposted by Stephen McLaughlin
Journal of Cell Biology @jcb.org · 17/04/2026
Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk: rupress.org/jcb/article/... #CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 15/04/2026
The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year. Applications are open now! More details: mrclmb.ac.uk/careers-and-... Please share this post with anyone who may be interested!
Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.
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Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...
youtube.com
Cryo-EM structure of yeast telomerase
YouTube video by MRC Laboratory of Molecular Biology
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Reposted by Stephen McLaughlin
IMPRS for Living Matter @imprs-lm.bsky.social · 17/03/2026
📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!
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IMPRS for Living Matter @imprs-lm.bsky.social · 20/03/2026
🔍 Want to uncover how proteolytic enzymes in the ubiquitin system work—and exploit those insights for novel therapeutic approaches? Apply to the Gersch Lab @maltegersch.bsky.social at @imprs-lm.bsky.social. #proteolysis #ubiquitin #biochemistry #proteinchemistry
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/03/2026
📣 Fully funded PhD position available! Join @suyangzhang.bsky.social’s group to uncover how human cells coordinate RNA transcription and splicing. You’ll use biochemical, structural & cellular approaches, including #cryoEM. Apply by 14th April. More details: mrclmb.ac.uk/careers-and-... #PhDposition
3D molecular model showing a complex protein structure with blue, green, pink, and gray regions bound to a twisted blue DNA strand.
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Reposted by Stephen McLaughlin
Buzz Baum @buzzbaum.bsky.social · 12/03/2026
Archaea hit prime time: www.bbc.co.uk/programmes/m...
bbc.co.uk
BBC Radio 4 - In Our Time, Archaea
How a discovery in the 1970s changed the theory of the origin of complex life on earth.
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
We are RECRUITING for maternity cover for our NMR facility at the UCL School of Pharmacy - expected from April until February. Come and join us! Details below, feel free to reach out to me informally for more information. Closing date *9 March*.
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Reposted by Stephen McLaughlin
Lori Passmore @lapassmore.bsky.social · 25/02/2026
We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...
nature.com
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636
Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...
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Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺 @ettema.bsky.social · 16/02/2026
Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...
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Sjors Scheres @sjorsscheres.bsky.social · 16/02/2026
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...
mrc.tal.net
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 13/02/2026
How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...
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Reposted by Stephen McLaughlin
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 27/01/2026
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry. Read more: www.nature.com/naturecareer... Apply by 11 FEB #PostdocJobs #ScienceJobs
Suyang Zhang smiles in front of a blurred laboratory background
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Stephen McLaughlin @lmbbiophysics.bsky.social · 27/01/2026
Are you interested in finding out how biological questions can be investigated with a range of molecular techniques? Find out how the MRC-LMB facilities tackle problems here: www.youtube.com/playlist?lis...
youtube.com
Molecular Techniques Training Seminars 2025 - YouTube
The recordings are from the LMB's recent series of training seminars 'Biophysical Techniques Course: Solving Probes with Molecular Techniques.' Featuring exp...
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Reposted by Stephen McLaughlin
Kelly Nguyen @kellythd-nguyen.bsky.social · 23/01/2026
Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social. www.nature.com/articles/s41...
nature.com
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle - Nature Communications
To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at t...
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Suyang Zhang @suyangzhang.bsky.social · 23/01/2026
🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬 Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing Apply here by 11 Feb www.nature.com/naturecareer...
nature.com
Postdoctoral Researcher - Structural Studies - Dr Suyang Zhang - LMB 2761 - Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12852642
Postdoctoral Researcher Salary £42,694 per annum  MRC Laboratory of Molecular Biology, Cambridge, UK We are recruiting a Postdoctoral Researcher to...
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Alan Brown @alanbrownhms.bsky.social · 18/11/2025
Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526
academicpositions.harvard.edu
HMS - Postdoctoral Fellow in BCMP, Brown Lab
We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...
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Ariane Briegel @arianebriegel.bsky.social · 18/11/2025
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 18/11/2025
Want to join the LMB as a PhD student in October 2026? You’ve got two weeks left to apply! Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd December 2025.
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025
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Stephen McLaughlin @lmbbiophysics.bsky.social · 14/11/2025
Thanks to the speakers and all who attended our Next Generation Biophysics Symposium. We now looking forward to the 10th Symposium on 16th September 2026. Here is a link to catch up on what happened in this year's
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Tanmay Bharat @tbharat-lab.bsky.social · 13/11/2025
Assembly, architecture and functional roles of microbial surface layers Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social. S-layers are everywhere! www.nature.com/articles/s41...
nature.com
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 06/11/2025
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software. www.nature.com/naturecareer... Apply by 25 NOV #PostdocJobs #ScienceJobs
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Suyang Zhang @suyangzhang.bsky.social · 23/10/2025
Our lab @mrclmb.bsky.social in Cambridge is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry www2.mrc-lmb.cam.ac.uk/students/int...
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Sjors Scheres @sjorsscheres.bsky.social · 16/10/2025
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...
beta.ideas.lego.com
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/10/2025
Considering a PhD in molecular biology? Make sure to check out the projects on offer at the LMB! www2.mrc-lmb.cam.ac.uk/students/int... General applications by 2nd DEC. US Gates Scholarship applications by 15th OCT. #PhD
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025
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Stephen McLaughlin @lmbbiophysics.bsky.social · 19/08/2025
Excited that we are only two weeks away for our Next Generation Biophysics Symposium 2025. We have a fantastic line-up of speakers. Registration is closing soon. Come in person or view on-line #Biophysics #SingleMolecule #CryoEM #nmr #proteindynamics
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Syma Khalid @sykhalid.bsky.social · 10/08/2025
Carol Robinson on Desert Island Discs - have a listen friends: www.bbc.co.uk/sounds/play/... An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless) @kavlioxford.bsky.social
bbc.co.uk
Desert Island Discs - Professor Dame Carol Robinson, scientist - BBC Sounds
Dame Carol Robinson, scientist, shares the soundtrack of her life with Lauren Laverne.
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Sjors Scheres @sjorsscheres.bsky.social · 12/08/2025
Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳 How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look. www.cell.com/structure/fu...
cell.com
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...
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Phil Holliger @philholliger.bsky.social · 14/07/2025
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
jobs.ac.uk
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
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Alessandro Costa @costalaboratory.bsky.social · 21/07/2025
Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...
crick.wd3.myworkdayjobs.com
Postdoctoral Fellow - Costa Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...
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