Platelets fulfill their essential physiological roles sensing the extracellular environment through

Constructing atomic models from cryogenic electron microscopy (cryo-EM) density maps is essential fo

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Structures of the human calcium-sensing receptor can be bound into complex with G proteins from three different Gα subtypes while maintaining G-protein-binding specificity.

Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

RyR1 is an intracellular Ca2+ channel important in excitable cells. Ca2+ activates it at low concent

Structural interrogation of α7 nicotinic receptor positive modulation clarifies class-specific differences, reveals unique properties of the α7 subtype, and supports a conserved potentiation mechanism...

Read the Community guidelines for GPCR ligand bias: IUPHAR review 32: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15811Browse the British Journal...

NASW is transitioning to Bluesky as its short-form social media platform for community building. Find out how NASW members can join the conversation.

Systematic mutagenesis reveals the structural basis of adrenaline’s effects on its receptor.

Stanford University is seeking a CryoEM Scientific Manager for the operations of the Stanford CryoEM Center (cEMc; https://med.stanford.edu/cemc)....

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Heterotrimeric G proteins play a central role in cellular signaling, acting as switchable molecular

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

How to deal with continuously flexing molecules is one of the biggest outstanding challenges in sing

Protein function strongly depends on temperature, which is related to temperature-dependent changes

Masuho et al. measured the kinetics of GPCR enzymatic activity, revealing ranks of G protein selectivity for 124 GPCRs. This led to development of GPCRs’ functional classification, identification o...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution