Vaccination programs have played a key role, and GPs remain ‘instrumental’ in boosting screening rates to reach the 2035 target.

Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...

Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

OrganoidTracker 2.0 enables fast and accurate cell tracking in complex systems such as developing organoids. A key aspect of the work is determining cell tracks with error probabilities for any tracking feature, from cell cycles to lineage trees.

Menstrual disturbance has been reported as a symptom of post-acute COVID-19 while other long COVID symptoms may vary across the menstrual cycle. Here, the authors investigate this possible bidirection...

Abstract. The mammary gland, which primarily develops postnatally, undergoes significant changes during pregnancy and lactation to facilitate milk producti

In this perspective, Gray et al. discuss recent advancements in the understanding of breast epithelial cell types, driven in part by single-cell technologies, and present their consensus on the proper...

The scientific community is invited to submit project concepts to help us study NAMs. The goal is to build scientific confidence and regulatory acceptance.

Meyer et al. identify a poor-prognosis basoluminal tumor cell phenotype in triple-negative breast cancer. Favorably prognostic are tumor-CD8+ T cell interactions, HLADR expression on tumor cells, and B cell patches. Patient stratification based on tumor cell cytokeratin expression and tumor-immune interactions identifies groups with distinct outcomes across molecular subtypes.

UCLA researchers have successfully grown miniature lungs from stem cells — complete with their own functioning blood vessel networks.The groundbreaking work, detailed in Cell, marks the first time sci...

Cambridge researchers are working to undo a longstanding male bias in health research, to help drive more effective healthcare for all.

Liang et al. study the impact of ERα antagonist/degraders against different Esr1 mutations in murine models and find that inhibition of mutant ERα induces lineage plasticity, which is also observed in...

The FDA has announced plans to phase out animal testing in the development of monoclonal antibodies and other drugs.

This paper describes a framework for classifying small insertions and deletions from genomic data and applies it to a large dataset comprising seven tumor types. The analysis highlights new insertion ...

In recognition of Endometriosis Awareness Month, we caught up with Charlotte Cassie, Postdoctoral Fellow at the Wellcome Sanger Institute, to highlight the gap in endometriosis research and how our wo...

Abstract. Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiate...

The representation of driver mutations in preleukemic HSCs provides a window into the somatic evolution that precedes AML. Here, Poon et al. isolate pHSCs from the bone marrow of 16 patients with AML ...

Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcino...

Some women who receive a false-positive result on a mammogram may not come back for routine breast cancer screening in the future, a new study has found.

Join us to explore how stem cell competition can lead to premalignancy and cancer in this interactive event!