Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis. Bac...

by Hiroshi Nikaido — LB medium, also known incorrectly as Luria-Bertani medium, is widely used to grow bacterial cultures, mainly because it is easy to prepare and provides a broad base of nutrien…

Abstract. Toxin-antitoxin systems (TAs) are widespread in bacterial genomes. Yet, their integration, persistence, and impact in chromosome dynamics remain

When used as antibacterial agents, Peptide Nucleic Acid (PNAs) are generally designed to base-pair with complementary sequences of an essential mRNA and block translation initiation. Although bacteria...

Bacterial sRNAs are pervasive post-transcriptional regulators, yet how they arise, evolve, and decay remains poorly understood. Here, we provide a high-resolution transcriptome map and curated sRNA se...

Nature Microbiology, Published online: 10 August 2026; doi:10.1038/s41564-026-02459-4Recombitrons enable bacterial genome editing across phyla

A nanopore-based ‘chop and measure’ method sequences peptides at single-amino-acid resolution by using enzymatic digestion to progressively shorten the N terminus one residue at a time,...

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

Abstract. Small regulatory RNAs (sRNAs) are major post-transcriptional regulators in bacteria and, together with transcriptional regulators such as the two

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establis...

Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...

The molecular basis for long-term survival of starved bacteria is not well understood. The bacterium Rhodopseudomonas palustris has a metabolism in which it survives in growth arrest for months, as lo...

The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...

Nature - Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light microscopy.

I'm delighted to announce that we - ELiS Lab / Inserm U1338 at the nascent Paris Biofoundry and the Computational, Quantitative, Synthetic Biology Dept. at the Sorbonne Université - are recruiting an ...

Spratt et al. evaluate the transcriptional regulation of Salmonella pathogenicity island 2 (SPI-2) at the single-cell level, revealing temporally tunable phenotypic heterogeneity that allows for proba...

The architecture of Bacillus subtilis biofilms is influenced by the coordinated regulation of cellular specialization, matrix assembly, and metabolism. B. subtilis can form different types of biofilm ...