Only 5–10% of TB-infected people develop active disease. Researchers at the Francis Crick Institute are identifying immune biomarkers that predict who wi… #Biomarkers #Immunology #InfectiousDisease #Preventivemedicine #Tuberculosis

The COVID-19 Origin Theory that Sabotaged Science and Society

Background In tuberculosis (TB) low-incidence countries, TB is becoming increasingly concentrated in marginalised populations. Progress towards TB elimination therefore requires targeted interventions...

British-born, older men among those most likely to have disease found only postmortem, say researchers One person a week dies with undiagnosed and therefore untreated tuberculosis in England, a study has found. British-born, older men were among those most likely to have TB diagnosed only after death, researchers said, suggesting healthcare workers could be overlooking the possibility of the disease in these patients. Continue reading...

Gabbard’s declassification theater is a case study in politicizing intelligence.

Tuberculosis remains a major global health threat, and rapid, accurate diagnosis is essential for disease control. This study evaluates an updated molecular assay for detecting the Mycobacterium tuber...

from the album Inferno

Early recognition of clinically-discordant mycobacterial cultures is essential to prevent unnecessary diagnostic procedures and treatments. Here, we s…

Infections caused by nontuberculous mycobacteria (NTM) are increasingly recognized worldwide, yet the long-term epidemiology of these human pathogens remains poorly understood. By leveraging a unique ...

Existing treatments for tuberculosis (TB) and HIV control the pathogens, but the immune system does not revert to normal, according to research by Texas

SUMMARYThe global resurgence of drug-resistant tuberculosis (DR-TB) presents a formidable challenge to public health, driven by a complex interplay of mycobacterial evolution, dynamics and outcomes of...

Mycobacterium avium subsp. hominissuis (MAH) is a clinically important species of non-tuberculous mycobacteria that causes infections in a variety of hosts. This opportunistic pathogen is widespread i...

From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Background In 2013, a global outbreak of Mycobacterium chimaera infections due to contaminated heater-cooler units emerged. This ongoing problem has highlighted the question of whether disinfection re...

Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.

Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...

Without actions to restore discontinued services, cuts to health aid for tuberculosis and HIV programmes could result in millions of additional childhood tuberculosis cases and deaths in low-income an...

Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...

Background Despite being key components of global tuberculosis policy, poverty reduction and social protection interventions have been inconsistently implemented. We aimed to characterise how poverty ...

Here, the authors show that giving probiotics to very low birth weight preterm babies can help reduce harmful antibiotic-resistant bacteria in the gut and support the development of a healthier microb...

There is considerable interest in training machine learning (ML) models on genomic data that achieve clinical grade diagnostic accuracy. Many successful ML models have been trained and validated on bi...

Many Greenlanders move from Greenland, a tuberculosis (TB) high-incidence country, to Denmark, a TB low-incidence country. Surprisingly, according to official statistics, the TB incidence among Gre...

Effe et al. evaluate how specific plasmid traits influence plasmid fitness; they provide mechanistic insight into the persistence of large conjugative plasmids, including those that disseminate antibi...

Mycobacterium tuberculosis, the bacterium responsible for the Tuberculosis (TB) disease, remains a leading global infectious disease killer, and genomic epidemiology is essential for understanding its...

Nature - Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and...

BEAST X advances Bayesian phylogenetic, phylogeographic and phylodynamic analysis by incorporating a broad range of complex models and leveraging advanced algorithms and techniques to boost statistica...

Background Tuberculosis remains a global health concern, with rising pediatric and adolescent cases. The advancement of diagnostic strategies is crucial for effective control, with whole-genome sequen...

Background Pathogenic mycobacteria, such as Mycobacterium tuberculosis complex (Mtbc), and non-tuberculous mycobacteria (NTMs) can cause severe chronic pulmonary infections. However, not all infected ...

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Mycobacteria have coevolved with humans over millennia, leaving profound imprints on our immune systems. Beyond active disease, their exposure may exert immunomodulatory effects, including allergy mod...

Genomes from metagenomes have revolutionised our understanding of microbial diversity, ecology, and evolution, propelling advances in basic science, biomedicine, and biotechnology. Assembly algorithms...

An big screen documentary movie, an announcement, and an exclusive excerpt from "Lab Leak Fever", the definitive book unraveling the pandemic origin controversy

The United States was the major funder of tuberculosis programs. Now hundreds of thousands of sick patients can’t find tests or drugs, and risk spreading the disease.

Tuberculosis remains the leading cause of death by a single infectious agent worldwide, affecting 10·8 million people in 2023. The emergence of multidrug-resistant or rifampicin-resistant tuberculosis...

Here the authors train multivariate logistic regression models on over 52,000 MTBC isolates to associate binary resistance phenotypes for 15 antitubercular drugs with variants extracted from candidate...

🔎📰 𝐏𝐞𝐞𝐫-𝐫𝐞𝐯𝐢𝐞𝐰𝐞𝐝 𝐦𝐢𝐬𝐢𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 is – by my definition – persistent unsubstantiated information (deliberate or otherwise) widely…

Antimicrobial combination therapy is widely used to combat Mycobacterium tuberculosis ( Mtb ), yet resistance rates continue to rise. Mutator strains, with defects in DNA repair genes, are a known source of resistance in other bacterial infections, but their global role in Mtb remains unclear. Here, we provide a comprehensive overview of the contribution of single nucleotide polymorphisms (SNPs) in DNA Repair, Replication, and Recombination (3R) genes to resistance in Mtb . Through large-scale bioinformatics analysis of 53,589 whole-genomes, we identified 18 novel SNPs linked to genotypic drug resistance in 3R genes, covering 12.5% of clinical isolates/strains with available genome sequences. Notably, a number of the detected SNPs were positively selected during Mtb evolution. Experimental mutation frequency tests further indicated functional defects of these sequence variants in key DNA repair pathways. Our findings indicate that the role of mutability in 3R genes plays a significant role in Mtb resistance at the global level. ### Competing Interest Statement The authors have declared no competing interest.

Nye fund af bakterier fra historisk samling er et vigtigt skridt i forståelsen af såkaldte atypiske mykobakteriers rolle i sygdom. Fundet understreger værdien af Statens Serum Instit...

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