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Fabai Wu

@fabaiwu.bsky.social
135 followers 143 following 35 posts

Ass Prof of Microbiology at EITech Ningbo. www.microwulab.com

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Reposted by Fabai Wu
Simonetta Gribaldo @sgribaldo.bsky.social · 23/09/2026
Interested in #archaea, #methane, #cell-envelopes? New paper out @nature.com ! We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description www.nature.com/articles/s41... #MicroSky 🧵👇
nature.com
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Fabai Wu @fabaiwu.bsky.social · 6h
Asgard archaea on the move!
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Fabai Wu @fabaiwu.bsky.social · 27/07/2026
Discovery of a Turing reaction-diffusion system in Archaea! www.biorxiv.org/content/10.6...
biorxiv.org
A self-organized geometry sensing oscillator spatially regulates cell division in archaea
Cell division must be tightly regulate in time and space. Many bacteria and eukaryotes employ geometry sensing systems to regulate cell division spatiotemporally. However, how archaea ensure they divi...
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Fabai Wu @fabaiwu.bsky.social · 18/07/2026
Systematic identification of cell division proteins in haloarchaea and the discovery of a membrane anchor for the Z ring. www.biorxiv.org/content/10.6...
biorxiv.org
Systematic identification of cell division proteins in haloarchaea and the discovery of a membrane anchor for the Z ring
Most archaea rely on the tubulin-like protein FtsZ for division. In the last decade, several novel cell division proteins have been discovered in the model haloarchaeon Haloferax volcanii which contai...
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Reposted by Fabai Wu
Kate Michie @kmichie.bsky.social · 09/04/2026
Our paper is out today! See this news article on it. Asgard archea have some cool proteins. If you are interested in protein evolution it’s a really exciting space. I’m lucky to be a structural biologist in the age of DL🧬🧶 @brendanburns999.bsky.social @iduggin.bsky.social @debnathghosal.bsky.social
phys.org
From Asgard to Earth: Tiny tubes may reveal the moment complex life began
Stromatolites—and their close relatives, microbial mats—could be mistaken for what seems like a bunch of old dark rocks. But instead, they are dense, layered communities of microbes. Long before compl...
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Tominaga K. (tomiken) @pacyc184.bsky.social · 10/04/2026
An Asgard archaeon from a modern analog of ancient microbial mats: Current Biology www.cell.com/current-biology/fullte…
cell.com
An Asgard archaeon from a modern analog of ancient microbial mats
A novel Asgard archaeon, Nerearchaeum marumarumayae, is present in microbial mats in Shark Bay, Australia. Combining genomic and structural analyses, together with high-resolution electron cryotomography, Nobs et al. reveal that these archaea possess unique cellular features that reflect their ancestry as progenitors of the earliest eukaryotic cells.
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Brett Baker @archaeal.bsky.social · 13/03/2026
Having a hard time keeping up with the fast-moving field of origin of eukaryotes/Asgards archaea? Our new perspective article can help, we review the status of research over the last decade and where it's going. The archaeal roots of eukaryotic life www.pnas.org/doi/10.1073/...
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Fabai Wu @fabaiwu.bsky.social · 06/03/2026
Asgard archaea: have we found our microbial ancestors? link.springer.com/article/10.1...
link.springer.com
Asgard archaea: have we found our microbial ancestors? - The EMBO Journal
The discovery of Asgard archaea about a decade ago has greatly reshaped our understanding of archaeal evolution and the origin of eukaryotes. Asgards are currently thought to be the closest prokaryoti...
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Fabai Wu @fabaiwu.bsky.social · 06/03/2026
10 years of massive Asgard undertaking, masterly summarized!
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Kassiani Panagiotou @kassipan.bsky.social · 05/03/2026
Just over ten years after the discovery of the first Asgard archaeal genomes, we revisit the rapid expansion of this remarkable archaeal lineage. From diverse genomes and metabolisms to eukaryotic signature proteins and the first cultured representatives. www.nature.com/articles/s41...
nature.com
Diversity, ecology, cell biology and evolution of the Asgard archaea - Nature Reviews Microbiology
The Asgard archaea have become a cornerstone of archaeal research, particularly for studies aiming to unravel the origin and early evolution of eukaryotes. This Review outlines the current state of th...
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Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺 @ettema.bsky.social · 05/03/2026
Finally out in @natmicrobiol.nature.com: Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Great work by @stephkoe.bsky.social @kassipan.bsky.social @jvhooff.bsky.social www.nature.com/articles/s41...
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Fabai Wu @fabaiwu.bsky.social · 06/03/2026
Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling
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Fabai Wu @fabaiwu.bsky.social · 19/02/2026
Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor
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Reposted by Fabai Wu
Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺 @ettema.bsky.social · 16/02/2026
Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...
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Cameron Thrash @jcamthrash.bsky.social · 22/01/2026
Our latest. Led by the very talented @ahoiching.bsky.social Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation www.nature.com/articles/s41... #jcampubs 🌊
nature.com
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation - Nature Microbiology
Without key cell cycle control genes, SAR11 cells experience aneuploidy and growth inhibition when exposed to changes in nutrients, carbon sources or temperature stress, a vulnerability that may repre...
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Victor Tobiasson @victortobiasson.bsky.social · 18/01/2026
Dominant contribution of Asgard archaea to eukaryogenesis. tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea! #science #biology #evolution #nature #bioinformatics www.nature.com/articles/s41...
nature.com
Dominant contribution of Asgard archaea to eukaryogenesis - Nature
A survey of the reconstructed gene set of the last eukaryotic common ancestor shows a consistent link between Asgard archaea and the origin of numerous, functionally diverse eukaryotic genes, dem...
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mLife Journal @mlifejournal.bsky.social · 04/01/2026
New Issue Alert — mLife Vol. 4, Issue 6 is out! The issue features 10 open-access papers spanning host–pathogen interactions, bacterial cell division, RNA editing, phage therapy, CRISPR optogenetics, and more. Table of contents here 👉 onlinelibrary.wiley.com/doi/10.1002/... Highlights below ⬇️
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mLife Journal @mlifejournal.bsky.social · 29/12/2025
Join the IC-DLI x mLife Webinar on Deep Life Studies! 🗓 Dec 30 | 🕐 13:00 UTC | 🧪 3 exciting talks on: • Deep-sea cold seep microbiomes • Novel methanogens beyond Euryarchaeota • Habitable rock–water systems 📍Zoom ID: 853 4219 3531 | PW: 904477
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Reposted by Fabai Wu
Miaoxiao Wang (Roy) @miaoxiaor.bsky.social · 18/12/2025
Come to follow the official BlueSky of the journal #mLife!
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mLife Journal @mlifejournal.bsky.social · 22/12/2025
Insightful Review in #mLife! Emerging single-cell sequencing and imaging technologies now allow for the profiling of microbial heterogeneity with unprecedented resolution—capturing phenotypic and spatial diversity within microbial communities. 🔗 doi.org/10.1002/mlf2...
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ISEP @isepprotists.bsky.social · 23/11/2025
Discovery of rare #protist reveals previously unknown branch of eukaryotic tree of life phys.org/news/2025-11... Rare microbial relict sheds light on an ancient eukaryotic supergroup www.nature.com/articles/s41... #Protists #Microbes #Evolution #Eukaryotes #TreeOfLife
microscopic pictures and 3D reconstructions of a microbial cell
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Cameron Thrash @jcamthrash.bsky.social · 21/11/2025
An archaeal genetic code with all TAG codons as pyrrolysine www.science.org/doi/abs/10.1... #jcampubs
science.org
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
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Reposted by Fabai Wu
Tanmay Bharat @tbharat-lab.bsky.social · 07/11/2025
An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
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Fabai Wu @fabaiwu.bsky.social · 11/11/2025
Asgards everyday! Another boost to the metabolism at the prokaryote-eukaryote interface.
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Reposted by Fabai Wu
Daan Speth @daanspeth.bsky.social · 10/06/2025
I'm happy to announce the latest release of the GlobDB, available at globdb.org. The GlobDB is a database of "species dereplicated" microbial genomes, and as of release 226 contains twice the number of species-representative genomes (306,260) than the latest GTDB release.
globdb.org
home | GlobDB
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PLOS Biology @plosbiology.org · 24/10/2025
Bacteria rely on retrons for #phage defense, but most known systems come from clinical or lab strains. @seth-shipman.bsky.social &co identify diverse #retrons from environmental #bacteria, uncovering their defense mechanisms & using them as #GenomeEditing tools @plosbiology.org 🧪 plos.io/4oDqRAF
Isolation of retron-bearing hosts from environmental samples. Top: Schematic of the isolation of bacteria from soil and water samples and identification of possible retron-bearing hosts using PAGE analysis (from left). Retron RT-DNA bands from PAGE analyses. Overview of sampling, screening of colonies, and identification of retron hosts. Hosts displaying an RT-DNA band were subjected to whole-genome sequencing. RT-DNA was subjected to unbiased adapter addition and sequencing. Bottom: Top left panel: Schematic of canonical retron operon with components annotated, effector in pink, noncoding RNA (ncRNA) in orange, and reverse transcriptase in purple. Other seven panels: Seven putative retron operons, identifying the retron type, host species, and predicted two-dimensional structure of the ncRNA. For retrons where RT-DNA sequencing is available, sequencing coverage is plotted onto ncRNA in an orange heatmap (heatmap legend indicated number of sequencing reads mapped). Gene abbreviations: NDT (nucleoside deoxyribosyltransferase-like); PRTase (phosphoribosyltransferase); WH (winged helix-turn-helix DNA binding); HTH (helix-turn-helix domain containing); HipA (HipA-like); DUF (DUF3037 domain-containing protein).
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Fabai Wu @fabaiwu.bsky.social · 24/10/2025
How are we replicating our #DNA? Find origin in the #Asgard #Archaea!
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Reposted by Fabai Wu
STCmicrobeblog @stcmicrobeblog.bsky.social · 21/10/2025
chromosome replicationists – #Archaea branch, Asgard dept. – take note 👇 #ArchaeaSky thx @acritschristoph.bsky.social for boosting this 🙏
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Fabai Wu @fabaiwu.bsky.social · 21/10/2025
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
nature.com
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
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Cees Dekker @ceesdekker.bsky.social · 25/04/2025
Latest #CDlab paper on @biorxivpreprint.bsky.social: Spatial control of karyopherin binding avidity in NPC mimics revealed by designer FG-Nucleoporins www.biorxiv.org/content/10.1... With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
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Alex Bisson @archaeon-alex.bsky.social · 09/04/2025
It is the year of the (more?) complex prok multicellularity :)
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Cees Dekker @ceesdekker.bsky.social · 08/04/2025
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced! www.biochemistry.org/about-us/new... It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
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Nika Pende @nikapende.bsky.social · 04/04/2025
Sooo cool! Congrats @archaeon-alex.bsky.social and Co.!
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Fabai Wu @fabaiwu.bsky.social · 04/04/2025
We are looking for tenure-track and tenured biologists to join our department: School of Life Sciences at EITech Ningbo. It's a new private university, English taught, benefits and selection are both internationally competitive. Please apply & contact me if you have any questions. shorturl.at/Rjqku
nature.com
Tenure-Track and Tenured Positions in Life Sciences, Biotechnology, and Biomedical Engineering - Ningbo, Zhejiang (CN) job with Eastern Institute of Technology, Ningbo - Global Engagement Office | 128...
Seeking dynamic and outstanding individuals to join us in the College of Science and College of Engineering to expand our research capabilities.
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