Jeff Coller, a pioneering RNA biologist, has spent the past year vehemently advocating for the lifesaving promise of research in the face of federal cuts

The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

With falling vaccination rates and outbreaks that have caused more than 580 U.S. cases and at least two deaths, health experts expect hundreds or even thousands more to be infected in the coming month...

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A biweekly podcast for early career researchers, bringing together fantastic guests to discuss their research, careers + much more.

Survey of more than 1,600 biomedical researchers also flagged small sample sizes and cherry-picking of data as leading causes of reproducibility problems.

Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: Developing Drug and Biological Products in Oncology

As many as two billion people suffer from it — including me. Can science finally bring us relief?

Introduction Pain in patients with rheumatoid arthritis (RA) is an unmet clinical need. Targeting joint inflammation with disease modifying antirheumatic drugs (DMARDs) has not resulted in the anticip...

Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that ar...

The Vilcek Foundation accepts grant applications to support immigrant artists and communities, and diversity in the arts, sciences, and education.

RNAs are major drivers of phase separation in the formation of biomolecular condensates. Recent studies suggest that RNAs can also undergo protein-free phase separation in the presence of divalent ion...

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to contribute to cellular dysfunction in age-related disorders, including late-ons...

Small molecule kinase inhibitors are critical in the modern treatment of cancers, evidenced by the existence of over 80 FDA-approved small-molecule kinase inhibitors. Unfortunately, intrinsic or acqui...

The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off...

Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

Nature Communications - Cells adapt to low glucose by halting protein synthesis and altering organelle shape. Here the authors showed that hibernating ribosomes tether to mitochondria and form...

Proteins are functionally diverse molecules that exist in a plethora of conformations and structures or as disordered ensembles, depending on their pr…