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Dr. Shivani Ruparel

@shivanibr.bsky.social
234 followers 253 following 16 posts

Professor & Director of Research. Studies #orofacialpain, #cancerpain,#oralcancer . Love #travel ( blog at mytripscripts.com), #tennis and singing.

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Dr. Shivani Ruparel @shivanibr.bsky.social · 29/12/2025
A detailed Script of one of my most elite trips in the US #lovetravel #lovenature #alaska #glaciers #wildlife #summervacations mytripscripts.com/2025/12/29/a...
mytripscripts.com
A Dreamy Alaskan Summer: An Exquisite Trip through America’s Wildest Landscapes
Alaska had been on my travel wish list for a long time, and when we finally visited during the peak of summer, it turned out to be everything we imagined and more. From snow-capped mountains and ma…
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Dr. Shivani Ruparel @shivanibr.bsky.social · 10/12/2025
Center for Pain Therapeutics and Addiction Research. @uthealthsa.bsky.social is searching for a tenure-track faculty recruit. Outstanding Envt and colleagues. Please apply or share widely. #neuroscience #painresearch #addictionresearch #orofacialpain uthscsa.referrals.selectminds.com/faculty/jobs...
uthscsa.referrals.selectminds.com
CPTAR - Open Rank (Assistant/Associate/Professor) in San Antonio
The University of Texas Health Science Center San Antonio, School Dentistry, is seeking applications for a full-time position of a tenure...
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Dr. Shivani Ruparel @shivanibr.bsky.social · 07/11/2025
I was extremely lucky to receive two RO1s in the current climate literally just before the fiscal year end and government shutdown🙏 I so wish this was the story of all academic scientists in the US. #savescience news.uthscsa.edu/school-of-de...
news.uthscsa.edu
School of Dentistry at UT Health San Antonio awarded $6 million total to study treatment, pain management for oral cancer - UT Health San Antonio
Three multi-year NIH grants target painful disease with low survival rate Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, Nov. 7, 2025 – Researchers at the School of Dentistry at ...
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Reposted by Dr. Shivani Ruparel
The Journal of Pain @thejournalofpain.bsky.social · 23/06/2025
Original: Drs. Merlo, @shivanibr.bsky.social et al. discovered that TrkBT1, not full-length TrkB, is the main isoform in trigeminal nociceptors. It modulates BDNF-induced sensitization and survival, redefining TrkBT1 as an active player in pain signaling   Full: www.jpain.org/article/S152...
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Dr. Shivani Ruparel @shivanibr.bsky.social · 26/05/2025
My latest travel Post on Sedona AZ: A Relaxing getaway for all age groups. #travel #sedona #arizona trips #redrocks #americandesert mytripscripts.com/2025/05/26/c...
mytripscripts.com
Cool Trails & Red Rock Tales: A December Getaway to Sedona
There are some places that wrap you in a warm hug the moment you arrive, and Sedona in December is one of them. Nestled amidst towering red rock formations, this Arizona gem offers a tranquil retre…
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Dr. Shivani Ruparel @shivanibr.bsky.social · 21/05/2025
What we do in the newly established Center of Pain Therapeutics and Addiction Research (CPTAR) in School of Dentistry @uthealthsa.bsky.social #painresearch magazines.uthscsa.edu/schools/2025...
magazines.uthscsa.edu
Looking beyond opioids - Magazines of the Schools at UT Health San Antonio
A revolution in pain exploration has been launched with the school’s new Center for Pain Therapeutics and Addiction Research. Interdisciplinary collaboration is helping investigators study non-opioid ...
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Dr. Shivani Ruparel @shivanibr.bsky.social · 21/05/2025
For early-stage investigators grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-114: Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period NOT-OD-25-114. OD
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Dr. Shivani Ruparel @shivanibr.bsky.social · 17/05/2025
Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...
sciencedirect.com
Truncated TrkB: The predominant TrkB isoform in nociceptors
Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral…
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Dr. Shivani Ruparel @shivanibr.bsky.social · 14/05/2025
Congratulations to my student Priya Narayanan for an excellent performance on defending her MS thesis focused on the molecular mechanisms underlying oral mucositis @uthealthsa.bsky.social. I am a proud mentor today. #teachingisrewarding #graduateeducation
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Dr. Shivani Ruparel @shivanibr.bsky.social · 03/05/2025
New paper out from my lab and Dr. Akopian's lab. First of its kind to characterize mechanically-gated trigeminal neurons in non-rodent higher order species. #painresearch #nonrodentmodels www.eneuro.org/content/earl...
eneuro.org
Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates
Pain sensation often involves mechanical modalities. Mechanically activated (MA) ion channels on sensory neurons underly responsiveness to mechanical stimuli. MA current properties have mainly been de...
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Dr. Shivani Ruparel @shivanibr.bsky.social · 01/04/2025
UT Health San Antonio ranks among the top 50 medical schools in the nation for National Institutes of Health research funding. news.uthscsa.edu/ut-health-sa...
news.uthscsa.edu
UT Health San Antonio’s accelerated rise: Advancing innovation, research and national impact - UT Health San Antonio
UT Health San Antonio’s Accelerated Rise: Advancing Innovation, Research and National Impact
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Reposted by Dr. Shivani Ruparel
Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · 01/04/2025
mbi.ufl.edu/2025/04/01/r...
mbi.ufl.edu
Researchers present latest advances in developing nonopioid pain relievers » McKnight Brain Institute » University of Florida
UF Center for Advanced Pain Therapeutics and Research (CAPToR) hosts inaugural symposium.
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Dr. Shivani Ruparel @shivanibr.bsky.social · 01/04/2025
Had a blast speaking and catching up w/ Nicole Scheff, @flybottleescape.bsky.social @robgereau.bsky.social @laurenslosky.bsky.social et al at the Center for Adv PainTher and Res (CAPToR) @ufresearch.bsky.social.Thank you @khannalabuf.bsky.social and @maykhanna.bsky.social for hosting us.
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Dr. Shivani Ruparel @shivanibr.bsky.social · 29/03/2025
www.sciencealert.com/oral-cancer-...
sciencealert.com
Oral Cancer Cases Are on The Rise, And Sugary Drinks Could Be to Blame
It may not just be tooth decay you need to worry about when it comes to sugary drinks: new research suggests that these sweetened beverages might also be raising the risk of oral cancer.
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Reposted by Dr. Shivani Ruparel
Michelle Monje @michellemonje.bsky.social · 21/03/2025
#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler. www.nature.com/articles/s41...
nature.com
Cancer research needs neuroscience and neuroscientists - Nature Neuroscience
The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...
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Dr. Shivani Ruparel @shivanibr.bsky.social · 20/02/2025
Yet another reason to be proud of @uthealthsa.bsky.social news.uthscsa.edu/ut-health-sa...
news.uthscsa.edu
UT Health San Antonio earns top Carnegie classification for research, doctorate awards - UT Health San Antonio
The University of Texas Health Science Center at San Antonio earned a Research 1 (R1) designation from the American Council on Education and the Carnegie Foundation for the Advancement of Teaching in ...
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Dr. Shivani Ruparel @shivanibr.bsky.social · 02/02/2025
Interesting article "suggesting a need to recalibrate recruitment expectations. Even moderately above-average individuals on these key dimensions may merit greater recognition due to their scarcity". www.sciencedirect.com/science/arti...
sciencedirect.com
The number of exceptional people: Fewer than 85 per 1 million across key traits
Cognitive biases can lead to overestimating the expected prevalence of exceptional multi-talented candidates, leading to potential dissatisfaction in …
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Reposted by Dr. Shivani Ruparel
UoG Spinal Cord Group @spinalcordgroup.bsky.social · 17/01/2025
Anyone interested in a PhD in pain research, we have a fully-funded position available in the Weir lab. www.findaphd.com/phds/project...
findaphd.com
Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling at University of Glasgow on FindAPhD.com
PhD Project - Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling at University of Glasgow, listed on FindAPhD.com
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Reposted by Dr. Shivani Ruparel
Anne-Marie Malfait @jointsintheworld.bsky.social · 15/01/2025
www.cell.com/cell-genomic...
cell.com
Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk
Kramer et al. analyzed gene expression, chromatin accessibility, and 3D chromatin structure in primary human chondrocytes in both normal and OA-like conditions. They mapped eQTLs, performed colocaliza...
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Reposted by Dr. Shivani Ruparel
Ted Price @tedpricethepainguy.bsky.social · 14/01/2025
@dereklowe.bsky.social on the evolving suzetrigine and acute and chronic pain story: www.science.org/content/blog... Certainly going to be some interesting times ahead in this area. I agree with him, I think the patient experience in the real world is going to be a huge determining factor...
science.org
The Pain Comes With the Territory
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Reposted by Dr. Shivani Ruparel
Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · 07/01/2025
Hope springs anew in 2025! 🌸 Here's to a year of breakthroughs in pain relief and brighter, pain-free days ahead for chronic pain patients. #PainRelief NaV1.8 inhibitor poised to provide opioid-free pain relief www.nature.com/articles/d41...
nature.com
NaV1.8 inhibitor poised to provide opioid-free pain relief
Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic.
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Dr. Shivani Ruparel @shivanibr.bsky.social · 01/01/2025
Wishing everyone and your families a very safe, healthy and an uneventful 2025! May the magic continue in all your lives😍
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Dr. Shivani Ruparel @shivanibr.bsky.social · 30/12/2024
My uncle in his retirement graduated from flying school, bought a plane and then built it, to tour around the world. And now I get to ride in it for free. I feel so royal 😬
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Reposted by Dr. Shivani Ruparel
Anne-Marie Malfait @jointsintheworld.bsky.social · 28/12/2024
arthritis-research.biomedcentral.com/articles/10.... on the role of macrophages in experimental OA pain
arthritis-research.biomedcentral.com
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage - Arthritis Research & Therapy
Background Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions report...
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Reposted by Dr. Shivani Ruparel
Ted Price @tedpricethepainguy.bsky.social · 27/12/2024
BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...
biorxiv.org
Truncated TrkB: The predominant TrkB Isoform in Nociceptors
Truncated form of the tropomyosin receptor kinase B isoform (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sens...
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Reposted by Dr. Shivani Ruparel
Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · 21/12/2024
POG, from dried roots of Saposhnikovia divaricata, may help treat #OA by regulating lncRNA XIST & Nav1.7. POG improves cartilage damage, reduces inflammation & chondrocyte apoptosis. Protective mechanism of Prim-O-glucosylcimifugin in the treatment of o... www.sciencedirect.com/science/arti...
sciencedirect.com
Protective mechanism of Prim-O-glucosylcimifugin in the treatment of osteoarthritis: Based on lncRNA XIST regulation of Nav1.7
LncRNA XIST and Nav1.7 have been identified to be significantly associated with the onset of osteoarthritis. Prim-O-glucosylcimifugin (POG) has antiin…
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Reposted by Dr. Shivani Ruparel
Ted Price @tedpricethepainguy.bsky.social · 21/12/2024
BOOM! Big advance from Zak Campbell's lab (Zak used to be at UTD and moved to U Wisconsin a couple of years ago, big loss for us) on regulation of BDNF translation in nociceptors - www.sciencedirect.com/science/arti...
sciencedirect.com
eEF2K regulates pain through translational control of BDNF
mRNA translation is integral to pain, yet the key regulatory factors and their target mRNAs are unclear. Here, we uncover a mechanism that bridges nox…
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