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@denklab

@denklab.bsky.social
938 followers 437 following 75 posts

My team and I study why pain can become chronic. We like the peripheral nervous system, neuroimmunology, stromal cells and sequencing. If you have similar interests - please say hi!

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@denklab @denklab.bsky.social · 20/04/2026
We are hiring! www.linkedin.com/posts/teodor...
linkedin.com
#medicalresearch #pain #arthritis | Teodora Trendafilova, PhD
I am very happy to be advertising the position below for a post-doc to join me and Franziska Denk at King’s College London, Wolfson SPaRC (Sensory, Pain and Regeneration Centre). It’s a very exciting...
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Brian Nosek @briannosek.bsky.social · 02/04/2026
The SCORE investigation of repeatability and credibility is a lot. There are a few ways to get your head around it. 1: The Nature collection includes 3 papers from SCORE, an amazing paper from @i4replication.bsky.social and several commentaries about the work. www.nature.com/collections/... 1/
nature.com
Reliable research in the social and behavioural and sciences
Sweeping new investigations probe the replication, robustness and reproducibility of results across the behavioural and social sciences.
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Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 24/03/2026
@denklab.bsky.social leads an international consortium awarded €1.4m by @eraneuron.bsky.social to research causes and treatments for #NeuropathicPain. @mwklab.bsky.social @carolineospelt.bsky.social are also chief investigators. @nihrmaudsleybrc.bsky.social www.kcl.ac.uk/news/interna...
kcl.ac.uk
International Neuropathic Pain consortium awarded €1.4m grant | King's College London
DECIPHER, an international consortium on Neuropathic Pain led by King’s College London, has been awarded €1.4m by ERA-NET Neuron to research the role of connective tissue in neuropathic pain.
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Annina Schmid @anninaschmid.bsky.social · 26/02/2026
We are hiring a postdoc! If you love culturing neurons and are stellar at electrophysiological characterisation and imaging of sensory neurons, then come and work with us on this cool multi-lab project!🧑‍🎓 👩‍🎓 my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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Pain Research Forum @painresforum.bsky.social · 26/11/2025
Have you been wondering what the role is of non-neuronal cells in modulating sensory neuron activity? Check out this review from @psalmotoxin.bsky.social et al. in @sfnjournals.bsky.social’s #JNeurosci, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/3XEp2rE #PRF
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Ewan St. John Smith @psalmotoxin.bsky.social · 12/11/2025
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch Here's our accompanying review! www.jneurosci.org/content/45/4...
Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease
production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades,
injured or sensitized neurons potentiate pain and the development of a chronic pain state.Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage
degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling
nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details.Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to
mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated
with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory
neurons that is sent to the spinal cord and brain through touch and pain pathways.
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Ted Price @tedpricethepainguy.bsky.social · 01/11/2025
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
biorxiv.org
A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
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Ewan St. John Smith @psalmotoxin.bsky.social · 04/11/2025
A new #PainResearch paper from us at @phar.cam.ac.uk 😃 Led by Luke Paine from the Bulmer Lab, supported by @javimmunopain.bsky.social & others, & it’s all about acid; not the hallucinogenic kind, but rather H+ www.cmghjournal.org/article/S235...
cmghjournal.org
GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception
Localised acidification from immune cell infiltration and heightened glycolysis contributes to colitis pathology by activating acid-sensing receptors such as GPR68, a proton-sensing GPCR expressed on ...
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Will Renthal @willrenthal.bsky.social · 07/11/2025
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology! Paper: biorxiv.org/content/10.1... Data: humandrg.painseq.com
biorxiv.org
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Angelika Lampert @lampertlab.bsky.social · 30/10/2025
🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease. 🧠 Abstracts due Nov 2 🔗 sodiumchannelconference2026.org/WELCOME/ #NaV #ionchannels #cardiacphysiology #scienceconference
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Adrian Liston @labliston.bsky.social · 28/10/2025
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...
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Laura Fedele @lau-fed.bsky.social · 27/10/2025
Happy to share our new preprint doi.org/10.1101/2025... We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org
Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes
Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, ...
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Women in Neuroscience UK @womeninneurouk.bsky.social · 12/10/2025
Prof Selina Wray will join us as our careers keynote, sharing her journey from a working class background and part time work through to a professorship, and Dr Carole Torsney, our research keynote, will tell us about her preclinical research on sex & gender disparities in pain.
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Ted Price @tedpricethepainguy.bsky.social · 08/10/2025
Coming soon thanks to @ish1789.bsky.social sparc.science/datasets/480. Lots and lots of data!
sparc.science
SPARC Portal
The open community platform for bridging the body and the brain through neuroscience and systems physiology data, computational and spatial modeling, and device design.
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George Goodwin @gg9761.bsky.social · 06/10/2025
Stuart Bevan and I are offering an exciting MRC DTP-funded PhD project exploring the mechanisms of pain in Long COVID. Find out more about the project here: 🔗 tinyurl.com/3caseacv Application deadline: 28th October @wolfsonsparc.bsky.social y.social @kingsioppn.bsky.social sioppn.bsky.social
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Andy Bell @belllab.bsky.social · 04/10/2025
New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1
Labelled axons of calb1+ spinal projection neurons innervate multiple brain targets associated with cold sensation and thermoregulation. Darkfield images of different brain areas including the postal parabrachial and periaqueductal grey are shown with axons of ascending cells in yellow.
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Ewan St. John Smith @psalmotoxin.bsky.social · 02/10/2025
Great to have this out: wonderful team effort, & nice to build on work from others that had identified the dysregulated osteoarthritis lipidome 😃 #neuroskyence #PainResearch
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UK GIBA Network+ @ukgibanetwork.bsky.social · 01/10/2025
📊 Want to boost your research skills? Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10). ✅ Free to attend 🙋‍♀️ Open to all career stages 🚆 Travel and accommodation costs reimbursed Apply by October 17th 👉 www.giba-uk.org/training-opp...
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Ben Seymour @benosaka.bsky.social · 01/10/2025
We are proud to launch what we think is going to be fantastic opportunity for pain neuroscientists and clinicians to learn the foundations of pain neuroscience
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UK GIBA Network+ @ukgibanetwork.bsky.social · 29/09/2025
Our NEW working groups support effective collaborations across the UK. Could you help answer one of our first 5️⃣ key research questions? 👉 www.giba-uk.org/working-groups 🙋‍♀️ Ambitious ECRs are invited to co-lead each group. Apply before Friday 10th October.
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Dr. Ali Barry @aliibarry.com · 22/09/2025
Congratulations @amapruns.bsky.social and all! Can't wait to dig in to this dataset #PainResearch
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@denklab @denklab.bsky.social · 22/09/2025
If you are UK-based and interested in Gut-Immune-Brain Axis research, do sign up to our GIBA+ network and its working groups! You will get access to lots of new contacts, publication and funding opportunities 🧪🧠🤑 #PainResearch #PainScience #neuroskyence #ImmunoSky
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UK GIBA Network+ @ukgibanetwork.bsky.social · 22/09/2025
The past two decades have seen a global explosion of research into the gut-immune-brain axis. There is great energy in #Southampton today for our #GIBANetworklaunch. Together, we are building a vibrant and diverse research community to fully realise GIBA's potential. Learn more 👉 www.giba-uk.org
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Ted Price @tedpricethepainguy.bsky.social · 13/09/2025
New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub
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Dr. Ali Barry @aliibarry.com · 08/09/2025
Thanks to everyone who made #NeuPSIG2025 so great, and to the photographer here who somehow managed to capture everyone (?) at this table
Photo of the Bennett lab and extended folks at a long table out for dinner.
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Ewan St. John Smith @psalmotoxin.bsky.social · 05/09/2025
Fancy a #neuroskyence trip to Alicante in December? You can propose yourself to give a talk at the 22nd Christmas Meeting of Alicante's Institute for Neurosciences: in.umh-csic.es/en/communica...
in.umh-csic.es
Christmas Meeting - Instituto de Neurociencias de Alicante
Este tradicional encuentro, que se realiza en el mes de diciembre de cada año, tiene como finalidad la interacción de investigadores que actualmente trabajan en instituciones de prestigio internaciona...
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Sara E. Jager @thisissarajager.bsky.social · 07/09/2025
On my way home after an excellent trip. First, I went to Poland to visit @mwklab.bsky.social and give a talk together with @gg9761.bsky.social and Jimena Perez-Sanchez. Next, we all went to Berlin 🚂 to participate in #NeuPSIG where I got to hang out with more of my favorite scientists! #PainResearch
Me, Mat, George and Jimena standing in the auditorium after our sessionMe standing in front of my poster looking very happy
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Dr. Ali Barry @aliibarry.com · 03/09/2025
Quick reminder as we head into #NeuPSIG that we have a #PainResearch feed and conferences are the best time to force your friends to join bsky bsky.app/profile/did:...
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Dr. Ali Barry @aliibarry.com · 28/08/2025
What better way to get excited for #NeuPSIG2025 than a @utdpaincenter.bsky.social test run of our Machine Learning Workshop? #PainResearch
screenshot of a zoom meeting and a Rmd knit for a "Machine Learning in Neuropathic Pain" document
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Ted Price @tedpricethepainguy.bsky.social · 24/08/2025
BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.
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Daniel Lakens @lakens.bsky.social · 25/08/2025
If you are preparing your bachelor statistics course and would like to add optional material for students to better understand statistics on a conceptual level (see topics in the screenshot) my free textbook provides a state of the art overview. lakens.github.io/statistical_...
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@denklab @denklab.bsky.social · 25/08/2025
Many congratulations again on this fabulous piece of work! 🎉🥳 Required reading for people in #PainResearch #painscience
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Steve Middleton @middletonsj.bsky.social · 21/08/2025
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future! www.nature.com/articles/s41...
nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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Alles Lab @alleslab.bsky.social · 21/08/2025
Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch
nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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@denklab @denklab.bsky.social · 21/08/2025
Congrats @amy-lock.bsky.social on another great paper based on your PhD! #PhDSky this should also be of interest to people on #Immunosky #AcademicSky
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Amy Lock @amy-lock.bsky.social · 20/08/2025
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further! www.biorxiv.org/content/10.1... @denklab.bsky.social #fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
biorxiv.org
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...
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Diana Tavares Ferreira @dianatavf.bsky.social · 19/08/2025
This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
jci.org
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy
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Ewan St. John Smith @psalmotoxin.bsky.social · 16/08/2025
Happy #Caturday 😺😺😺
Matilda, white cat, standing on a blue table in the gardenBertie, grey cat, standing on a blue table in the gardenHenry, black cat, lying on the cat tree
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Felix Viana @neuroviana.bsky.social · 16/08/2025
Summer nap
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Stephani Sutherland @sutherlandphd.bsky.social · 09/08/2025
Have you checked out the relaunch of PRF? Editors’ picks are selected by rotating editorial board members like @gregscherrer.bsky.social @painresforum.bsky.social
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International Society for Neuroethology @neuroethology.org · 07/08/2025
Naked mole-rats exhibit reduced inflammatory pain compared to mice. In a comparative study Lanhui Qiu & @psalmotoxin.bsky.social show that artemin has a conserved role in mice & naked-mole rats by mediating inflammatory pain in dorsal root ganglia (in vitro). link.springer.com/article/10.1...
link.springer.com
Artemin sensitises mouse (Mus musculus) and naked mole-rat (Heterocephalus glaber) sensory neurons in vitro - Journal of Comparative Physiology A
The naked mole-rat (NMR, Heterocephalus glaber) is a subterranean rodent that exhibits a range of unusual physiological traits, including diminished inflammatory pain. For example, nerve growth factor...
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Laura Fedele @lau-fed.bsky.social · 29/07/2025
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
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Ewan St. John Smith @psalmotoxin.bsky.social · 24/07/2025
A good #PainResearch week for Lanhui Qiu in the lab. After being co-first author on our sphingomyelin paper www.oarsijournal.com/article/S106..., her sole first author paper examining the effects of artemin on mouse vs. naked mole-rat sensory neurons is out 😀 link.springer.com/article/10.1...
media.tenor.com
a cartoon penguin with the words success penguin behind him
Alt: A cartoon penguin with the words success penguin behind him
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Ewan St. John Smith @psalmotoxin.bsky.social · 19/07/2025
Our #PainResearch paper showing that sphingomyelin 34:1 (⬆️ in 🧍osteoarthritis synovial fluid) sensitises 🐁 sensory neurons in vitro & causes pain behaviours + knee-innervating neuronal hyperexcitability in 🐁 in vivo is now out in @oacjournal.bsky.social: shorturl.at/Yii8H Skytorial 👇 #neuroskyence
sciencedirect.com
The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice
Osteoarthritis (OA) has a multifactorial pathogenesis, pain being the main symptom driving clinical decision making. Dysregulation of multiple mediato…
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Dr. Ali Barry @aliibarry.com · 23/07/2025
We have a new preprint ⤵️
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International Association for the Study of Pain (IASP) @iasp.bsky.social · 23/07/2025
The Pain Research Forum has relaunched—built for the global pain research community. Explore curated papers, expert content, and join discussions on The Pain Researcher. Registration is free: painresearchforum.or... #PRF #PainResearch #IASP #OpenScience
New PRF Website Social
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Ewan St. John Smith @psalmotoxin.bsky.social · 17/07/2025
Excited to see the new website up and running, such a powerful resource for everyone in #PainResearch 😃
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International Association for the Study of Pain (IASP) @iasp.bsky.social · 14/07/2025
What is meant by ‘trustworthy’ research? Join PRF on 21 July, for the Improving Trust in Clinical Trials webinar and explore how trust in research can be built through practical tools and frameworks: bit.ly/4luQVMS #PainEducation #PainResearch
21 July PRF Webinar (2).png
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UK GIBA Network+ @ukgibanetwork.bsky.social · 14/07/2025
Are you interested in the gut-immune-brain axis (GIBA)? 🧠🔬 Researchers and stakeholders from all disciplines and backgrounds are invited to join the launch event for our UK GIBA Network+. 📅 Monday 22nd September 📍 Southampton Harbour Hotel Book here: www.eventbrite.co.uk/e/uk-giba-ne...
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UK GIBA Network+ @ukgibanetwork.bsky.social · 11/07/2025
Are you interested in the gut-immune-brain axis (GIBA)? 🧠💡 We are building a national research network to improve understanding of the connection between the gut and nervous system. Join our growing community 👇 forms.office.com/Pages/Respon...
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