Longitudinal MRI reveals that the cortex becomes relatively thicker years before amyloid positivity is detected on PET, providing insight into the earliest brain changes and potential consequences of ...

A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to promote healthy ageing, lower disease risk and ex...

We have a 3-year researcher position for analysing longitudinal brain MRI data in relation to cognitive- and other biomarker data.The shift to a biomarker-based definition of Alzheimer’s disease (AD) ...

Anatomical tumor distribution provided prognostic information beyond overall tumor burden in glioblastoma. Regional patterns expand on the anatomical basis of symptoms. The survival benefit associated...

Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...

An autonomous robot system, Ace, combines event-based vision and reinforcement learning to compete with elite human table tennis players, highlighting the potential of physical AI agents to perform co...

What can we learn from 1,000 meta-analyses across 10 different disciplines? - Volume 17 Issue 1

Abstract. How can scientific progress be conceived best? Does science mainly undergo revolutionary paradigm shifts? Or is the evolution of science mainly c

KRONIKK: Troverdig forskning er ikke forskning uten usikkerhet. Det er forskning som viser oss usikkerheten i stedet for å skjule den.

Translational Psychiatry - White matter microstructure differences between 15q11.2 copy number variation carriers and non-carriers in mid-to-late life

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

The Journal of Headache and Pain - Migraine is a leading cause of disability worldwide, affecting hundreds of millions of individuals. Repetitive transcranial magnetic stimulation (rTMS) offers a...

... and a happy new year.

Abstract. MRI has revolutionized our ability to investigate and understand brain structure and function in health and disease. A large amount of MRI data is widely available to researchers, both from ...

Objectives: Despite growing evidence supporting tele-neuropsychology (teleNP), clinicians have voiced concerns about comparability to traditional in-person testing and the limited availability of t...

A data-driven framework for targeting replication funding where it matters most

There is increasing interest in developing imaging-based models to characterize 'brain-age', but how accurate are these for predicting neurological disease? This study shows that simpler models, which...

Background Continuous biomedical data is often dichotomized into two or more groups for analysis, despite long-standing warnings from statisticians that this constitutes bad practice. This dichotomisa...

Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations. The findings support a mo...

De fleste forskere sier de mener det er viktig å dele negative resultater, men langt færre gjør det i praksis. En ny undersøkelse fra Springer Nature viser at 98 prosent av forskerne er enige i at nul...

What can authors and reviewers do to keep common statistical mistakes out of the literature?

Scientific Data - The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

Global and subcortical brain volumes demonstrate sex-specific increases (white matter, hippocampus, amygdala, and pallidum) and decreases (cortical grey matter, total brain volume, caudate, putamen, ...

Molecular Psychiatry - Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder

The authors review evidence that the primary function of the brain, supported by distributed neural systems, is the predictive regulation of physiology (i.e., allostasis). An example from Alzheimer’s ...

Scientific Reports - Multimodal predictors of disability progression and processing speed decline in relapsing–remitting multiple sclerosis

As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However,...

We introduce ComBatLS, a new harmonization method that preserves the effects of biological covariates like sex and age on brain feature distributions' variances or scale parameters. We show that ComB...

Translational Psychiatry - Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy

Despite their promise, current neuroimaging biomarkers often fail to capture the full spectrum of inter-individual variability in brain structure and aging effects. This limits their ability to detect...