A new Postdoctoral Researcher in fMRI methods job is available in Bethesda, Maryland. Check it out on Organization for Human Brain Mapping.

Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at th...

Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy. However, the underlying biological mechanism of ultrasonic neuromodulation remains unclear, hindering the development of efficaci …

Hyperemia in response to neural activity is essential for brain health. A hyperemic response delivers O₂ and nutrients, clears metabolic waste, and concomitantly exposes cerebrovascular endothelial cells to hemodynamic forces. While neurovascular research has primarily centered on the fro …

Hands-on tutorials for the book Elements of fMRI Analysis: runnable MATLAB and Python code, thought questions, and self-quizzes for all 42 chapters.

Nitric oxide (NO) is a highly versatile gasotransmitter that has first been shown to regulate cardiovascular function and then to exert tight control over a much broader range of processes, including neurotransmitter release, neuronal excitability, and synaptic plasticity. Endothelial NO synthase (e …

It is unknown how the brain orchestrates coordination of global neural and vascular dynamics. We sought to uncover the role of a sparse but unusual population of genetically distinct interneurons known as type-I nNOS neurons, using a novel pharmacological strategy to unilaterally ablate these neuron …

Naturalistic stimuli, such as movies and narratives, are increasingly used in cognitive neuroscience to map cognitive and affective processes onto brain activity measured with functional MRI (fMRI). F...

A few years ago, Jo Etzel and I got into a brief but useful investigation of the effects of apparent head motion in fMRI data collected wi...

This paper benchmarked fMRI denoising pipelines on task- and resting-state, single- and multi-echo fMRI datasets, in a modern 1-step regression framework, with pre-whitening and time-shifted physiolo...

These findings demonstrate that tFUS exerts bidirectional, parameter-dependent modulation of a sensory pathway and highlight the critical role of CaMKII-positive neurons in mediating these effects. Th...

In January I speculated on the role of blood vessels  as the possible site(s) of primary activity for transcranial focused ultrasound (tF...

A recent study by Epp et al. uses advanced, quantitative functional MRI measures to demonstrate that the ‘canonical’ interpretation of blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) — ...

A new approach to magnetic resonance imaging, ‘multiplexed magnetic resonance imaging’, is reported, which enables high-resolution simultaneous multiparametric mapping of multiple molecules in standar...

Selectively modulating specific brain-rhythm bands with physical stimuli helps both to reveal neural mechanisms and to provide non-pharmacological treatment avenues for brain disorders. This study pro...

A number of studies showed that stimulus or task conditions can alter the shape of the hemodynamic response (HR). Contrary to variations across brains and brain regions, vascular factors alone cannot ...

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