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Cam-CAN

@camcan-2010.bsky.social
108 followers 117 following 15 posts

Cambridge Centre for Ageing and Neuroscience: studying healthy ageing of brain and cognition. www.cam-can.org

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MRC Cognition and Brain Sciences Unit, University of Cambridge @mrccbu.bsky.social · 25/09/2026
In a new analysis of a US cohort of older adults, Lihua Xia and colleagues find evidence that bilingualism supports cognitive reserve in aging, in that the baseline cognition of bilinguals was less dependent on their brain structure: doi.org/10.1016/j.neurobiolaging.2026.09.008
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Cam-CAN @camcan-2010.bsky.social · 20/07/2026
Protocol paper for Phases 4-5 of CamCAN below (many thanks to @inadem.bsky.social). We hope to have data organised to share on CamCAN website by end of the year!
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Rik Henson @rhens.bsky.social · 07/07/2026
Fantastic perspective on peer review by @rorinstitute.bsky.social, with some great ideas for future improvements to the current limping system: doi.org/10.6084/m9.f...
doi.org
The Future of Peer Review: A system-wide perspective
This report presents the main outcomes of the PEER REVIEW project conducted by the Research on Research Institute (RoRI) from 2023 to 2026. It draws on the substantial literature on peer review as well as 39 in-depth interviews with experts from across the research system, including policymakers, funders, publishers, editors, researchers and others. Peer review is often seen as one of the cornerstones of the research system. At the same time, many researchers and other actors in the system have expressed deep concerns about dysfunctions of peer review. In response to this, much work has been done to assess and improve peer review in individual domains, notably within research funding, scholarly publishing, career advancement, and assessment of research units.However, by considering peer review in each domain in isolation, knowledge about peer review has remained fragmented, offering a weak basis for strengthening the organisation of peer review.In this report, we take a systemic perspective on peer review across domains. Rather than focusing on incremental process-level innovations in individual domains, we conclude there is a need for system-wide reform in peer review. We outline future pathways for such reform.
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Cam-CAN @camcan-2010.bsky.social · 05/06/2026
New preprint on effects of age on MEG power spectra using CamCAN's unique longitudinal (10+ year) data... www.biorxiv.org/content/10.6...
biorxiv.org
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MRC Cognition and Brain Sciences Unit, University of Cambridge @mrccbu.bsky.social · 28/05/2026
Using a stochastic dynamical model, Grodem et al show that, before age 60, inter-individual differences in neuroanatomical volumes almost exclusively reflect stable differences between individuals, rather than systematic differences in rate-of-change: doi.org/10.1162/IMAG.a.1242
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Cam-CAN @camcan-2010.bsky.social · 22/05/2026
Lovely work using PREVENT cohort (and Cam-CAN in a lesser role ;-)
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Alex Wiesman @alexwiesman.bsky.social · 28/04/2026
How does chemoarchitecture influence brain signaling as we age? 🧠⚛️🧓 Our new study suggests that high-frequency connectivity is orchestrated by neurochemical similarity with a ++ role of slow neuromodulators which 📈 and preserves cognition as we age doi.org/10.64898/202... #neuroskyence
doi.org
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Cam-CAN @camcan-2010.bsky.social · 22/03/2026
New preprint by @inadem.bsky.social dissociating cortical thickness and surface area in their effects on cognitive change in ageing: www.biorxiv.org/content/10.6...
biorxiv.org
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Rik Henson @rhens.bsky.social · 19/03/2026
This is really worrying and would impede all the great science being done through sharing data (including testing reproducibility). It would be yet another blow to the US position as an international leader in science.
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Cam-CAN @camcan-2010.bsky.social · 13/03/2026
Nice review by @rhens.bsky.social of the >300 papers using CamCAN data to study the cognitive neuroscience of aging rdcu.be/e73yS - thanks to the authors of all those papers!
rdcu.be
Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing
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Cam-CAN @camcan-2010.bsky.social · 16/02/2026
Includes some preliminary CamCAN data showing how white-matter microstructure and functional connectivity contribute to cognition beyond gray-matter volume...
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Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 14/01/2026
An international research effort combining brain imaging and memory testing from thousands of adults is offering a clearer picture of how age-related brain changes affect memory. @andersfjell.bsky.social Learn More in Nature Communications @natureportfolio.nature.com 👉 www.nature.com/articles/s41...
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Cam-CAN @camcan-2010.bsky.social · 27/11/2025
Another nice use of multiple cohorts, including Cam-CAN
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Reposted by Cam-CAN
MRC Cognition and Brain Sciences Unit, University of Cambridge @mrccbu.bsky.social · 27/11/2025
Why do some people lose memory faster with age? A mega-analysis of 13 longitudinal datasets (3,700+ adults, 10,000+ MRIs) shows that memory decline tracks brain atrophy, especially in the hippocampus, and that these links strengthen with age, but not APOE status: www.nature.com/articles/s41...
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MRC Cognition and Brain Sciences Unit, University of Cambridge @mrccbu.bsky.social · 17/11/2025
We are excited to announce #COGNESTIC 2026 @mrccbu.bsky.social in Cambridge, between 14-25 Sep 2026. Our 2-week summer school provides training in state-of-the-art methods for open neuroimaging analysis and great opportunities for professional networking: www.mrc-cbu.cam.ac.uk/events/cogne...
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Cam-CAN @camcan-2010.bsky.social · 14/10/2025
Another interesting paper from LifeBrain consortium suggesting that sex differences in healthy brain aging are unlikely to explain higher prevalence of Alzheimer’s disease in women www.pnas.org/doi/10.1073/...
pnas.org
Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s disease prevalence in women | PNAS
As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However,...
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Cam-CAN @camcan-2010.bsky.social · 17/09/2025
"CamCAN 15 years on" - a new preprint reviewing all findings about the cognitive neuroscience of ageing from sharing CamCAN data, led by @rhens.bsky.social : osf.io/preprints/ps...
osf.io
OSF
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Cam-CAN @camcan-2010.bsky.social · 29/08/2025
New CamCAN study led by @praykov.bsky.social used 11 different white matter (WM) measures to show that WM health is multidimensional: 4 latent MRI-derived factors explained 89% of WM variance, were predicted by vascular health, and predicted cognition: doi.org/10.1038/s415...
doi.org
Complementary MR measures of white matter and their relation to cardiovascular health and cognition - Scientific Reports
Scientific Reports - Complementary MR measures of white matter and their relation to cardiovascular health and cognition
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Cam-CAN @camcan-2010.bsky.social · 27/08/2025
New CamCAN paper led by @noham-wolpe.bsky.social shows that older adults’ tendency to see facial expressions as more positive may not be the adaptive “rose-coloured glasses” we thought, but could signal early cognitive decline and neurodegeneration: pubmed.ncbi.nlm.nih.gov/40854689/
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MRC Cognition and Brain Sciences Unit, University of Cambridge @mrccbu.bsky.social · 28/07/2025
International study shows that higher levels of education do not reduce rates of cognitive and brain decline in later years, contrary to views that education protects against such decline: www.nature.com/articles/s41... @rhens.bsky.social
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Cam-CAN @camcan-2010.bsky.social · 21/07/2025
More fantastic work on the importance of pulse pressure from @kamentsve.bsky.social ...
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Karen Campbell @karampbell.bsky.social · 20/05/2025
Updated version of this paper now published in Cerebral Cortex 🥳 doi.org/10.1093/cerc... @sarahhenderson.bsky.social is on a roll 🙌🏻 #PsychSciSky #neuroskyence #memory #aging
doi.org
Neural state changes during movie watching relate to episodic memory in younger and older adults
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Cam-CAN @camcan-2010.bsky.social · 19/03/2025
Nagrodzki et al. (@yacnag) examine attentional negativity bias in depression, linking slower processing of angry faces to increased activity in the insula, IFG, and parietal cortex. Findings suggest this bias may persist in remission: doi.org/10.1037/emo0... @APA_Journals
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Christina Stier @cstier.bsky.social · 04/03/2025
Temporal autocorrelation is predictive of age — out now! www.pnas.org/doi/10.1073/... We used @camcan-2010.bsky.social #MEG data and massive time-series feature extraction (hctsa) to understand which aspects of neural activity predict a person's age. #PNAS #aging #MEG #Neuroscience #Neuroskyence
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Cam-CAN @camcan-2010.bsky.social · 14/02/2025
Hello BlueSky - sorry it has taken us so long to move here from less-blue skies. Anyway please follow us if you're interested in healthy ageing of brain and cognition, including scientific outputs and news from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.org).
cam-can.org
Cambridge Centre for Ageing and Neuroscience – The Science of Ageing
The Science of Ageing
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