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edvardg.bsky.social

@edvardg.bsky.social
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Anders M Fjell @andersfjell.bsky.social · 25/05/2026
Up to age 60, adult brain volume completely dominated by stable individual diffs. At 80 yrs, up to 50% reflects differences in change. Interpretation: 1) We change similarly up to 60. 2) Group comparisons often not reflecting changes. @Edvardosg @LCBC_UiO direct.mit.edu/imag/article...
direct.mit.edu
Stable Individual Differences Dominate Adult Brain Volume Variation Until Later Life
Abstract. Individual differences in the volumes of brain structures are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains ...
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Reposted by @edvardg.bsky.social
Anders M Fjell @andersfjell.bsky.social · 09/05/2026
Use of brain age models frequently lead to wrong conclusions - unfortunately it is not easy to fix. Fortunately, there are better alternatives. @edvardg.bsky.social @fmrib-steve.bsky.social @didacvp.bsky.social @maxwellelliott.bsky.social @k.b.walhovd www.medrxiv.org/content/10.6...
medrxiv.org
Reconsidering Brain Age: Why Age-Prediction Models Fail as Measures of Brain Aging
Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...
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Reposted by @edvardg.bsky.social
Anders M Fjell @andersfjell.bsky.social · 23/01/2026
Does memory fade slowly, or in drops and bursts? We analyzed 728k tests from 210k people. Key finding: “stability” isn’t a trait you either have or don’t have - it’s often a time-limited state at different points in aging. Preprint "Punctuated Memory Change": 👇 www.biorxiv.org/content/10.6...
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Reposted by @edvardg.bsky.social
Anders M Fjell @andersfjell.bsky.social · 21/08/2025
Using 4570 longitudinal MRIs + 1684 Aβ PET scans from cognitively healthy older adults @jamesmroe.bsky.social find cortical thickness changed ≥7 years before PET-detectable Aβ. Those who later developed high Aβ already had thicker cortex & less thinning. @LCBC_uio www.biorxiv.org/content/10.1...
biorxiv.org
Cortical thickness changes precede high levels of amyloid by at least seven years
Alzheimer's disease (AD) is now defined based on its underlying brain pathology, with the presence of amyloid (Aβ) plaques at high enough levels sufficient to warrant a diagnosis in the absence of cog...
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Reposted by @edvardg.bsky.social
Anders M Fjell @andersfjell.bsky.social · 30/05/2025
Preprint: before age 60, between-people diffs in brain vols almost exclusively reflect stable diffs, while systematic diffs in rate-of-change in aging cause up to 40% of the variation to be due to change at 80 years. @edvardg.bsky.social 🧵https://www.biorxiv.org/content/10.1101/2025.05.26.655710v1
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