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Dr. Seema Mattoo

@mattoolab.bsky.social
764 followers 136 following 85 posts

Assoc. Professor, Purdue U. (via India - U. Maryland, College Park - UCLA - UCSD/HHMI). Having fun studying Fic proteins, from bacteria to humans. #AMPylation #HypothesisFund
www.bio.purdue.edu/lab/mattoo

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Reposted by Dr. Seema Mattoo
Max Kozlov @maxkozlov.bsky.social · 04/09/2026
The agreement was signed out of the public view a month ago by Pentagon official Robert Kadlec and NIH Director Jay Bhattacharya, echoing my reporting. It establishes a 10-year framework that officially runs through September 30, 2036.
nature.com
Revealed: inside the US military's plan to tap huge sums from the NIH
An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense.
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Reposted by Dr. Seema Mattoo
Saganism @sagan.bsky.social · 07/08/2026
Dr. Anthony Fauci urges Americans not to accept "Normalization of Untruths".
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Dr. Seema Mattoo @mattoolab.bsky.social · 30/07/2026
Honored to be elected to the Editorial Board of @asm.org journal #mSphere. I cover Post-Translational Modifications, Bacteriology, Host-Pathogen Interactions, and Toxin/Effector Secretion & Function. Looking forward to working with ASM, and grateful for this opportunity.
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ASM @asm.org · 01/07/2026
Please welcome @vscooper.micropopbio.org as the new ASM President and Federico Sisti, Ph.D., as President-Elect. They begin their terms on July 1. ASM congratulates its new & continuing leaders and looks forward to their leadership in advancing ASM’s mission. asm.social/2Zx
Headshots of ASM's new leaders
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Dr. Seema Mattoo @mattoolab.bsky.social · 09/06/2026
Day 3 of @asm.org also reconnected me with fellow @hypothesisfund.bsky.social awardee @kacarlab.bsky.social! She is such a star 🤩
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Dr. Seema Mattoo @mattoolab.bsky.social · 09/06/2026
After 4 days at @asm.org, we microbiologists not only start dressing alike in matching colors, but looking alike too! 😜 Pictured here with Victor DiRita, Lawrence Di Rita, Heidi Kaplan, Theresa Kohler.
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Reposted by Dr. Seema Mattoo
Dr. Michael D. L. Johnson @copperbae.bsky.social · 06/06/2026
Hey #ASMICROBE I give my talk tomorrow and have two really cool things I want to share with everyone. You’ll have to come by to hear them!
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Dr. Seema Mattoo @mattoolab.bsky.social · 05/06/2026
Honored to serve on @asm.org #ASMmicrobe2026 Scientific Programming Committee. Spotlighting my sessions below - do attend! 1. TODAY, June 5, 11:45am, Hub - w/ Tiffany Zarrella 2. June 7, 9am, 151AB - w/ Victor DiRita, @copperbae.bsky.social Sarah Stanley & Hualiang Pi
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Dr. Seema Mattoo @mattoolab.bsky.social · 05/06/2026
Day 1 of @asm.org #ASMmicrobe2026 was great! Wonderful reconnecting with the Microbiology community, including fellow @hypothesisfund.bsky.social family members @laahrs.bsky.social & @paulturnerlab.bsky.social!
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Dr. Seema Mattoo @mattoolab.bsky.social · 25/04/2026
Former students revisiting my notes in Med/Grad school, thanking me for sparking their love for Microbiology - that’s the real reward. Still, nice to have the work recognized w/ the department’s highest teaching award. Grateful & honored. www.bio.purdue.edu/news/article...
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Philip Ball @philipcball.bsky.social · 18/04/2026
Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment. So here's a 🧵. /1 www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Dr. Seema Mattoo @mattoolab.bsky.social · 16/04/2026
What happens when Purdue U. has its own airport? The Biological Sciences faculty share a quick 6am pow-wow and hugs as they jet off to their individual seminar and conference destinations across the country! DC, LA, Charlotte… here we come! #PurdueScience
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Dr. Seema Mattoo @mattoolab.bsky.social · 15/04/2026
Excited to share our work w/ colleagues at @univofmaryland.bsky.social this week. Thanks to Vincent Lee for the invitation. Looking forward to connecting with UMD, NIH & other colleagues in the area; hope you can attend the seminar!
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Reposted by Dr. Seema Mattoo
Gc Rox @gcrox.bsky.social · 14/04/2026
Postdoctoral Position (Please re-post) A funded postdoctoral position for a recent graduate to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology. Please contact Hank Seifert h-seifert@northwestern.edu #Microsky, #Microbiology, #MicrobialEvolution
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Dr. Seema Mattoo @mattoolab.bsky.social · 14/04/2026
A busy, exciting few days at Purdue w/ GREAT seminar visits from Hank Seifert @medillschool.bsky.social & @copperbae.bsky.social @uarizona.bsky.social! Thanks, Hank & Michael, for excellent scientific discussions. Big thx admin & IT staff for help w/ visits, & to all who participated.
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Reposted by Dr. Seema Mattoo
Harmit Singh Malik @harmitmalik.bsky.social · 13/04/2026
I was interviewed by @katiepickup.bsky.social recently for @dmmjournal.bsky.social. This has a little bit of my background, a little bit on science and mentoring, and a little bit (ok, more than a little bit) on funding in science. Check it out at: journals.biologists.com/dmm/article/...


How important do you feel discovery research and ‘basic’ science is for understanding disease?

Well, I have a little bit of a biased view on the topic, since I'm a basic scientist myself. The lab has made more and more discoveries with very strong therapeutic implications, and often people ask me why we are not pursuing these further ourselves. Part of it is that I think about this very much as an ecosystem. People have different skills – I have colleagues who are very good at the application side of things and I have other colleagues, including people in my lab, who are very good at the basic science. There are a lot of very smart people at every stage in the ecosystem and, sometimes, we have to acknowledge that we can't all be experts in every step. A lot of basic science discoveries will end up having profound implications in the clinic – if you don't have the full imagination about how to get it there, that's okay, because you're still a very important piece of the jigsaw puzzle and other people can help. If the basic science discoveries didn't exist, then it's quite possible that the well would run dry. We cannot simply rely on the idea that the therapies currently in clinical trials are going to be enough because we already know that – for diseases, such as cancer, and with rapidly evolving viruses – there needs to be a constant influx of new ideas to stay ahead of the arms race. I'd also make a plug for the fact that, ultimately, we are all interested in human disease, but disease research in humans is not ethical or possible. This is why creating and studying model organisms in a high-throughput, low-investment context is incredibly important. We cannot just say ‘okay, we're going to stop work on anything that is not related to human research’, because – actually – it's all relevant to humans.


Do you think basic science is particularly threatened by cuts to funding?

Science itself is quite uncertain. We do experiments wondering if they will even work. It's discovery, and you don't know where it's going to lead. It could lead to a billion-dollar company, something like mRNA vaccines or CRISPR-Cas9 gene editing, or it could simply be something that interests you. Sometimes it might appear esoteric from the outside, but there are very smart people dedicated to this work. We shouldn't lose sight of the fact that most of this work is paid for by taxpayers, but funding uncertainty creates a very unstable foundation. If the foundations are weak, people are going to get much more conservative about the science that they're doing and worry that ‘blue-skies research’ is not worth pursuing because it won't get funded. And that would be a mistake because all innovation in science really originates from blue-skies, basic research. The second thing that uncertainty does is send a message to our young trainees – who are our future – that this is not a career option that will provide professional and personal stability. I worry that this kind of uncertainty will mean we lose an entire generation of people, and that would be a loss we might not be able to overcome.
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Dr. Seema Mattoo @mattoolab.bsky.social · 10/04/2026
We #Boilermakers are thrilled to have @drannecarpenter.bsky.social & @runxishen.bsky.social join us as Purdue Biology colleagues! Welcome, Anne & Runxi!
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Reposted by Dr. Seema Mattoo
Microbetv @microbetv.bsky.social · 07/02/2026
Seema Mattoo explains Bordetella pertussis, the cause of whooping cough, and talks with Mark Martin about how vaccine hesitancy is driving the return of childhood diseases. @markowenmartin.bsky.social
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Dr. Seema Mattoo @mattoolab.bsky.social · 06/02/2026
Such an honor to share our work on @microbetv.bsky.social! And fun too! Thank you, @markowenmartin.bsky.social, for the invitation and for being such an enthusiastic host! @asm.org
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Reposted by Dr. Seema Mattoo
Jonathan Kagan @jkagan1.bsky.social · 06/02/2026
Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...
nature.com
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
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Reposted by Dr. Seema Mattoo
Pam Ronald @pcronald.bsky.social · 17/01/2026
NSF needs to hear from you. Among other points, I suggested: keep politics out of science; stop using the threat of cancelling scientific grants to try to control universities; increase NSF funding for fundamental research. Pls send around. Deadline is January 27. Thanks www.nsf.gov/od/updates/n...
nsf.gov
NSF seeks public input on its Fiscal Year (FY) 2026–2030 NSF Strategic Plan
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Reposted by Dr. Seema Mattoo
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 23/12/2025
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy www.federalregister.gov/documents/20...
federalregister.gov
Notice of Request for Information; Accelerating the American Scientific Enterprise
The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...
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Dr. Seema Mattoo @mattoolab.bsky.social · 24/12/2025
Why #ASMMicrobe matters… @asm.org
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Dr. Seema Mattoo @mattoolab.bsky.social · 22/12/2025
Submit your abstracts for ASM Microbe 2026! As a member of the Scientific Program Committee, I can vouch for great science with something for everyone! @asm.org asm.org/events/asm-m...
asm.org
ASM Microbe | Abstracts
ASM Microbe showcases the best microbial sciences in the world and provides a one-of-a-kind forum to explore everything from basic microbiology to translation and application.
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Reposted by Dr. Seema Mattoo
Jonathan Kagan @jkagan1.bsky.social · 26/11/2025
Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former). @clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
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Dr. Seema Mattoo @mattoolab.bsky.social · 24/11/2025
Dr. Rita Colwell. Truly inspiring in every way. And a #Boilermaker to boot! Happy birthday, Rita!
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Reposted by Dr. Seema Mattoo
Harmit Singh Malik @harmitmalik.bsky.social · 23/11/2025
Sharing this important article... for no reason whatsoever. "We must also continue to deepen and refine our understanding of fundamental biological processes because these details frequently hold the keys to major advances in applied research." elifesciences.org/articles/102...
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Reposted by Dr. Seema Mattoo
Jan-Ulrik Dahl (Dahl lab, ISU) @janulrikdahl.bsky.social · 09/11/2025
Want to help us as an abstract reviewer for the @asm.org #ASMMicrobe2026? Abstract Review Period: January 29 - February 5, 2026. Please fill out the Abstract Reviewer Interest Form: asm.org/Microbe2026-... Thanks for your help!
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Reposted by Dr. Seema Mattoo
Jeremy Berg @jeremymberg.bsky.social · 07/11/2025
NYT obituary of Jim Watson. A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology. [Gift Link] www.nytimes.com/2025/11/07/s...
nytimes.com
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
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Midwest Microbial Pathogenesis Conference @mmpconference.bsky.social · 23/10/2025
Mark your calendars! #mmpc2026 The 2026 Midwest Microbial Pathogenesis Conference will be take place September 25-27, 2026 at the University of Minnesota! We are excited to welcome keynote speaker Dr. Andy Camilli. Give us a follow and watch for important information here ➡️ mmpc2026.umn.edu
mmpc2026.umn.edu
Midwest Microbial Pathogenesis Conference | Midwest Microbial Pathogenesis Conference 2026
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Reposted by Dr. Seema Mattoo
ASM @asm.org · 09/10/2025
We're excited to welcome Glen McGugan, Ph.D., as ASM’s Scientific Director of the Mechanism Discovery unit! He’ll lead efforts advancing discovery-driven microbial sciences in physiology, genetics, genomics & more. ➡️ Learn more about the unit: asm.social/2Dy
Introducing ASM Mechanism Discovery Director Glen McGugan, Ph.D.
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Dr. Seema Mattoo @mattoolab.bsky.social · 07/10/2025
Fun kickoff to #150PurdueBIO celebrating 150 years of #Purdue Biological Sciences, w/ special guests Doug Robinson @jhu.edu & Jack Johnson @scripps.edu, & colleagues Janice Evans, Nick Noinaj. Thanks to Dept Head Perry Paschou! www.bio.purdue.edu/150/index.html
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Dr. Seema Mattoo @mattoolab.bsky.social · 06/10/2025
T-regs for the win! www.nobelprize.org/prizes/medic...
nobelprize.org
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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Reposted by Dr. Seema Mattoo
Ferric Fang, MD @fangferric.bsky.social · 28/09/2025
Today is the 97th anniversary of penicillin's discovery! Many know the story of Fleming's serendipitous find. But fewer know that the antibiotic-producing mold drifted in from a nearby lab where it was being studied during an unusually cool period that allowed it to grow. apnews.com/today-in-his...
apnews.com
Today in History: September 28, Alexander Fleming discovers penicillin
1924: First round-the-world flight 2020: Global COVID death toll reaches 1 million 2022: Hurricane Ian strikes Florida
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Jordan Jastrab @jordanjastrab.bsky.social · 26/09/2025
Thrilled to share my work from the @jkagan1.bsky.social lab! TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection! www.biorxiv.org/content/10.1... #microsky #immunosky
biorxiv.org
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
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Reposted by Dr. Seema Mattoo
Jeremy Berg @jeremymberg.bsky.social · 26/09/2025
NSF Graduate Fellowship announcement is finally posted! www.nsf.gov/funding/oppo... 1/2
nsf.gov
NSF Graduate Research Fellowship Program (GRFP)
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Dr. Seema Mattoo @mattoolab.bsky.social · 12/09/2025
An inspiring scientist & role model - the success of Lucy Shapiro’s mentees is a legacy worth celebrating, let alone her exceptional science & dedication to basic science discovery! Congrats Dr. Shapiro, winner Lasker-Koshland Special Achievement Award 🥇 👏 laskerfoundation.org/winners/pion...
laskerfoundation.org
Pioneering approach to bacterial cell biology & national leadership - Lasker Foundation
Lucy Shapiro
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Faye McNeill @vfmcneill.bsky.social · 07/09/2025
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
nytimes.com
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
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Dr. Seema Mattoo @mattoolab.bsky.social · 06/09/2025
When you break your leg, and THIS is the conversation you have with your friends! 🤣Makes my recovery so much more manageable :) Hope my like-minded dad joke lovers are aptly entertained!
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Erin Goley @goleylab.bsky.social · 17/08/2025
Beautiful mural honoring Henrietta Lacks painted by Baltimore community members popped up near Hopkins med campus recently.
Colorful mural painted on the side of a building with the likeness of Henrietta Lacks and the words “HeLa” and “Middle East” on it.
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Dr. Michael D. L. Johnson @copperbae.bsky.social · 04/08/2025
asm.org/press-releas...
asm.org
Scientific Societies File Supreme Court Amicus Brief in Support of NIH Grantees
ASM and fellow societies filed an amicus brief with the Supreme Court, calling for the swift restoration of NIH grant funding supporting early-career scientists, such as the MOSAIC program.
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dl2409.bsky.social @dl2409.bsky.social · 08/07/2025
Franklin W. Stahl, 95, Dies; Helped Create a ‘Beautiful’ DNA Experiment www.nytimes.com/2025/07/07/s...
nytimes.com
Franklin W. Stahl, 95, Dies; Helped Create a ‘Beautiful’ DNA Experiment
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Richard Sever @richardsever.bsky.social · 08/07/2025
"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...
biorxiv.org
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206
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Cascales Lab @cascaleslab.bsky.social · 08/07/2025
We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested: emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr
Portail Emploi CNRS - Offre d'emploi - Ingénieur d'Etude en Microbiologie (H/F)
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Dr Craig R McClain @drcraigmc.bsky.social · 24/06/2025
I've wanted to write this article for years. About my and other's struggles to even survive sometime in #academia. Thank you to the amazing editors at @plosbiology.org that gave me the forum to write this piece. #science
journals.plos.org
Too poor to science: How wealth determines who succeeds in STEM
From student to researcher, a career in science can come with a high price tag. This Perspective explores how persistent financial barriers limit who can succeed in science, revealing how wealth shape...
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Heran Darwin, PhD @heran.bsky.social · 30/06/2025
Any grad students interested in a career in science policy? Check out this opportunity: mirzayanfellow.nas.edu?utm_source=N...
mirzayanfellow.nas.edu
The Christine Mirzayan Science and Technology Policy Graduate Fellowship Program
This program is an early career educational and training opportunity. It is designed to engage its Fellows in the analytical process that informs U.S. science and technology policy.
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Reposted by Dr. Seema Mattoo
Andreas Bäumler @abaumler.bsky.social · 26/06/2025
The new open access policy of NIH will take effect next week (July 1st). All NIH funded research 🔬🧪🧬accepted after July 1st must be open access upon publication. Worried about fees? 💸 Check out how IAI stacks up against other journals—you might be surprised. #OpenAccess #SciComm #Microbiology
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Jeremy Berg @jeremymberg.bsky.social · 25/06/2025
New York Times article on the end (at least for the moment) of NIH grant terminations... [Gift link] www.nytimes.com/2025/06/25/s...
nytimes.com
N.I.H. Memo Pauses Cancellations of Medical Research Grants
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Dr. Seema Mattoo @mattoolab.bsky.social · 24/06/2025
Enjoyed presenting our work & latest collab w/ @rtsolis.bsky.social at #ASMicrobe! Great sharing the stage w/ @delafuentelab.bsky.social, @laahrs.bsky.social & @heran.bsky.social. A drawback speaking at a Plenary Session is how prominent your pimples & wrinkles are on the jumbo screen🤣😬
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