Cao et al. develop DEL-Ranking, a ranking-aware denoising framework that improves affinity prediction from noisy DNA-encoded library screens. The approach enables more accurate prioritization of molec...

Antimicrobial peptides (AMPs) are a promising solution to antimicrobial resistance, yet generative models for their design cannot control the physicochemical properties and motifs that shape activity ...

A Penn Medicine analysis led by César de la Fuente identifies hidden peptides that may kill drug-resistant bacteria.

César de la Fuente is on a mission to combat antimicrobial resistance by looking at nature’s own solutions.

O investigador, catedrático da Universidade de Pensilvania e director do Machine Biology Group, lidera o desenvolvemento de ApexFold, un novo modelo de intelixencia artificial que aprende como a estrutura dos péptidos se modifica en función das condicións químicas nas que se atopan. A estrutura das moléculas biolóxicas non é necesariamente fixa. Algúns péptidos poden permanecer […]

YouTube video by VinFuture Prize

Encrypted peptides are short bioactive fragments hidden within larger proteins that remain largely undercharacterized, obscuring their roles in immunity. This Essay explores how proteolytically releas...

Mitochondria are bacteria-derived organelles that coordinate major innate immune pathways, but whether mitochondrial genomes themselves encode direct antimicrobial functions is underexplored. Here, we...

Un equipo de investigadores de la Universidad de Pensilvania (EEUU), dirigido por el egresado de la Universidad de León (ULE) César de la Fuente, destacado

A computational de novo design framework enables the design of α-helical peptides that assemble into transmembrane barrel-stave pores (TBPs). Here, TBPs are designed for antimicrobial activity, with b...

Antimicrobial-resistant bacterial and fungal pathogens constitute a severe threat to public health. The pace at which new antimicrobials are being rel…

Public microbial genomes encode an immense record of biological diversity, evolution and molecular function, but much of this information remains difficult to reuse because raw sequencing data are not...

YouTube video by ASM - Microbes Make Our World

We aim to bring together high quality and novel research spanning applied microbial physiology, metabolic engineering, bioenergy, environmental biotechnology, ...

El programa de becas de posgrado en el extranjero de la Fundación la Caixa impulsa el talento joven en la ciencia

Antimicrobial-resistant bacterial and fungal pathogens constitute a severe threat to public health. The pace at which new antimicrobials are being rel…

Escucha este episodio de La mecánica del caracol gratis en iVoox. Hoy analizamos el fenómeno de la proliferación de bacterias resistentes a los antibióticos con tres especialistas que investigan posib...

Nature Microbiology, Published online: 19 June 2026; doi:10.1038/s41564-026-02408-1Deep learning reveals that prion-related proteins contain hidden ‘prionin’ peptides with antibacterial activity, including two candidates that reduced infections in mice.

The first head-to-head benchmarking competition for generative AI in antimicrobial peptide design.

The model, called ApexGO, tells researchers whether a given peptide is “likely to have antimicrobial properties.” 

YouTube video by Beyond Sciences Initiative Toronto

A suite of artificial-intelligence tools is helping to speed up the process of discovering new antibiotics.

Se trata de una de las principales academias de ciencias de Europa, que cuenta con 88 integrantes galardonados con el Premio Nobel Te puede interesar: La UDC lidera en A Coruña un estudio para prevenir futuras pandemias desde el comportamiento humano

Se trata de una de las principales academias de ciencias de Europa, que cuenta con 88 integrantes galardonados con el Premio Nobel Te puede interesar: La UDC lidera en A Coruña un estudio para prevenir futuras pandemias desde el comportamiento humano

Speakers: Cesar de la Fuente