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Marija Backovic

@marijabackovic.bsky.social
2.3K followers 784 following 57 posts

Group Leader at @pasteur.fr‬ in Paris | Member of the @virusfusion007 Unit | Biochemist PhD, Structural biologist | #herpes #ERVs #retroviruses

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Marija Backovic @marijabackovic.bsky.social · 04/07/2026
Kaposi's sarcoma herpesvirus in spotlight
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 27/06/2026
I gave a workshop on AlphaFold & related programs @ the University of Utah. Part 1 covers protein structure prediction before/after AlphaFold & deep learning neural networks. Part 2 covers the math behind the scores. Part 3 covers PyMOL & the webservers. youtube.com/@rolanddunbr...
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Marija Backovic @marijabackovic.bsky.social · 28/05/2026
How cool is this. Respect to pigeons. www.science.org/doi/10.1126/...
science.org
Getting home in the dark
Two mechanisms, independent of daylight, may enable pigeons to navigate using Earth’s magnetic field
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Marija Backovic @marijabackovic.bsky.social · 24/05/2026
At least some creatures enjoy the heatwave in Paris...
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Healthcare in Europe @healthcare-europe.bsky.social · 23/04/2026
After 15 years of human #papillomavirus #vaccination programmes across 🇪🇺 Europe, growing evidence confirms their long-term effectiveness. A new report from @ecdc.europa.eu highlights steady progress in #cervicalcancer prevention efforts. #HPV
healthcare-in-europe.com
‘Elimination of cervical cancer in the EU is becoming an achievable goal'
As Europe marks European Immunization Week (EIW) 2026, the European Centre for Disease Prevention and Control (ECDC) reports continued progress in human papillomavirus (HPV) vaccination across the Eur...
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 09/04/2026
Pour celles et ceux que ça intéressent, il existe une association "Mothers in Science" qui milite en faveur de l'égalité et de l'inclusion et propose de nombreuses actions afin d'améliorer les perspectives de carrière des femmes scientifiques avec des enfants www.mothersinscience.com
mothersinscience.com
Mothers in Science
We are a global nonprofit organization that advocates for mothers in STEMM and creates evidence-based solutions to promote workplace equity and inclusion of caregivers.
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Ben Engel @cellarchlab.com · 08/04/2026
This is why I’m not allowed in the wet lab anymore 🥼 🕺. My technique is too effective! 🤪 #PILife #TeamTomo 🧪
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Katie Mack @astrokatie.com · 03/04/2026
More context on this #Artemis II image: * This is the night side, lit by moonlight. You can see city lights in Spain & Portugal, & a sliver of day at lower right * The Sun is entirely behind Earth, which makes it a kind of solar eclipse, but w/ Earth doing the eclipsing instead of the Moon: ☀️🌍🚀🌕
A full disc image of Earth, as seen from the Orion Crew Module. The planet is a pale blue, swirling with white clouds and glowing slightly lighter blue in place from reflected light. At lower left, a large brown landmass is Africa, with Spain and Portugal with twinkling lights where the planet curves. At top right, auroras glow in a thin green glow, just barely separated from the planet's surface. Earth is set against the black of space (pic: NASA/R.Wiseman)
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Oded Rechavi @odedrechavi.bsky.social · 02/04/2026
Exposure to different viruses linked to Alzheimer's and vaccines prevent this, more and more proof accumulates over time (reviewers in higher impact journals: "but what's the mechanism?")
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Nature @nature.com · 30/03/2026
Becoming a parent is much more detrimental to women’s academic careers than it is to men’s Read the full story: go.nature.com/4v4rxmQ
IMPACT OF PARENTHOOD ON UNIVERSITY EMPLOYMENT. Line graph shows how the probability of holding a research position changes from four years before to seven years after having children.
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The New York Times @nytimes.com · 18/03/2026
In @nytopinion.nytimes.com “Not many problems can be solved by simply taking a daily pill,” Maia Szalavitz writes in a guest essay. “HIV infection is one of them, and we can’t afford to go back to the time when it wasn’t.”
nyti.ms
Opinion | It’s Cruel to Take Away People’s H.I.V. Medication
States are rolling back coverage for lifesaving medications.
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Marija Backovic @marijabackovic.bsky.social · 18/03/2026
Hard life according to my cat.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 17/03/2026
AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
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Nature Biotechnology @natbiotech.nature.com · 09/03/2026
Transposable elements, such as retrotransposons and endogenous retroviruses, are being recognized for their important roles in genome function and impact on disease development. How can we translate our growing understanding of the 'dark genome' into therapeutics? go.nature.com/4tQ1zTn rdcu.be/e7D2N
go.nature.com
Transposable elements in the dark genome - Nature Biotechnology
Transposable elements (TEs), such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development. Residing ...
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Carl Zimmer @carlzimmer.com · 09/03/2026
"Russian flu," the pandemic that hit in 1977, bears an evolutionary signature of having emerged from a lab, perhaps as part of a failed vaccine effort. Covid, mpox, Ebola, and other influenza pandemics don't. Here's my story on a new way to trace the origins of pandemics. Gift link: nyti.ms/46N0W33
nyti.ms
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 06/03/2026
🔬✊ One year later, we #StandUpForScience again. Attacks multiply. Funding shrinks. But our determination doesn't. Science isn't opinion, it's the foundation of democracy. Institut Pasteur researchers are mobilizing. Join us. #StandUpForScience2026 #ScienceMatters #ResearchMatters
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Marija Backovic @marijabackovic.bsky.social · 06/03/2026
This is why we need to study persistent infections beyond the primary diseases they cause. www.sciencedirect.com/science/arti...
sciencedirect.com
Immune-cognitive relationships across viral infections: A transnosological systematic review
The emergence of SARS-CoV-2 has renewed interest in the relationship between immunity and cognition. Despite decades of work, the impact of viral expo…
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Chise @sailorrooscout.bsky.social · 03/03/2026
I aspire to exude as much confidence as this little Kinesin protein strutting along a microtubule while hauling intracellular cargo. Look at that little guy go! 🔬🧪
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r2d2mh.bsky.social @r2d2mh.bsky.social · 03/03/2026
🎙️R2D2-MH coordinator @thomasbourgeron.bsky.social and #cocreation member Stéf Bonnot-Briey participated in a radio broadcast on #Autism, discussing #cocreation, science, lived experience and #inclusion. 🎧 Recommended for French speakers: www.radiofrance.fr/franceinter/... #HorizonEU #Resilience
radiofrance.fr
L'autisme
L’autisme est-il une maladie ? Une condition génétique ? Naît-on autiste ou le devient-on ? Pour mieux comprendre ce que la science sait de cette condition, qui touche environ 1 % de la population, Ch...
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 30/07/2025
[Resources] #AlphaFold protein and PPI prediction databases 1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org 2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr... 3️⃣ Human interactome prodata.swmed.edu/humanPPI 4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev 1/2
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PLOS Biology @plosbiology.org · 16/02/2026
Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social
plos.io
Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…
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Edoardo Gianni @edogia.bsky.social · 13/02/2026
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 05/02/2026
No, DeepMind has not solved the protein folding problem. #Alphafold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.
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Instruct-ERIC @instruct-eric.bsky.social · 29/01/2026
Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
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Admirable Women @admirablewomen.bsky.social · 26/01/2026
Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM
Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.
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Admirable Women @admirablewomen.bsky.social · 26/01/2026
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
Color photograph of Joan Steitz (Joan Argetsinger Steitz), the distinguished American molecular biologist and biochemist renowned for her groundbreaking discoveries in RNA biology, including the identification of small nuclear ribonucleoproteins (snRNPs) essential to RNA splicing. She is pictured in a close-up portrait within a laboratory or research setting, smiling warmly and directly at the camera with an engaging, approachable expression that conveys enthusiasm and expertise. Steitz has gray hair pulled back, striking blue eyes, and is wearing large, elaborate dangling earrings adorned with purple gemstones and metallic accents. She is dressed in a rich purple blouse. The softly blurred background includes scientific elements such as lab benches, equipment, monitors, charts, and partial signage, evoking the environment of her long career at Yale University where she served as Sterling Professor of Molecular Biophysics and Biochemistry. #JoanSteitz #MolecularBiology #WomenInScience #Biochemistry #RNA
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Boston Protein Design and Modeling Club @bpdmc.org · 15/08/2025
Have no fear if you weren't in the packed audience this week for @martinpacesa.bsky.social's awesome seminar, because you can check out the recording 👇 youtu.be/qQihl6If9vU
youtu.be
BindCraft: one-shot design of functional protein binders
YouTube video by Boston Protein Design and Modeling Club
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Martin Pacesa @martinpacesa.bsky.social · 22/01/2026
Huge congratulations @nboyd.bsky.social with Mosaic that absolutely killed in the competition! 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕2 did also pretty well with the second highest hit rate in the competition! proteinbase.com/collections/...
proteinbase.com
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Elisa Fadda @elisafadda.bsky.social · 22/01/2026
Excellent overview of the (mind-blowing) effects of the Shingles vaccine against dementia by @erictopol.bsky.social Ground Truth 🧪 "Two new studies add to a remarkable body of evidence for benefit" ⬇️ open.substack.com/pub/erictopo...
open.substack.com
Spotlight on the Shingles Vaccine—Again!
Two new studies add to a remarkable body of evidence for benefit
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Ed Belongia MD @belongia.bsky.social · 19/01/2026
"If Covid was a fire alarm, our response, incredibly, has been to rip out the wiring. Instead of correcting the underbuilt public health systems that allowed thousands to die in the dark, we are choosing to institutionalize blindness." 👇 www.statnews.com/2026/01/18/t... via @statnews.com
statnews.com
What lingers in ‘The Pitt’ is heartache. What’s missing is outrage
“I am hungry, so hungry, for some depiction of Covid that tells the truth. That what was done to us was not just unbearable, but wrong,” an emergency physician writes of “The Pitt.”
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François Lallemend @flallemend.bsky.social · 14/01/2026
Published in Cell, a new study shows that the immune system’s reaction to the common Epstein-Barr virus can ultimately damage the brain and contribute to multiple sclerosis, from a team @ki.se www.cell.com/cell/fulltex...
cell.com
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...
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Marc Veldhoen @marcveld.bsky.social · 13/01/2026
3 papers on EBV and MS Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS www.cell.com/cell/fu... 1/6
cell.com
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells share cross-reactivity and pathogenic features with T cell responses to EBNA1 from Epstein-Barr virus, and their activation worsens MS-like disease in mice.
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Thiago Carvalho @cyrilpedia.bsky.social · 10/01/2026
'But what if IAVs could use a different receptor? Our previous work revealed that the IAV subtypes H17N10 and H18N11, which have so far been detected exclusively in bats, use MHC-II molecules as entry receptors instead of the conventional sialic acid receptors'
journals.plos.org
A new path to spillover: MHC-II entry of influenza A viruses
Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via ...
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Lars-Anders Carlson @lacarlson.bsky.social · 09/01/2026
Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info. Deadline 8 Feb. Apply here: umustipendie.varbi.com/en/what:job/... #virus #virology #teamtomo #cryoEM
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Aris Katzourakis @ariskatzourakis.bsky.social · 08/01/2026
Wanting to do some paleovirology of your own? We recently published HI-FEVER, enabling users to run their own fast searches for endogenous viral elements. Huge thanks to @humanceae.bsky.social, @emma-harding.bsky.social, José Gabriel and Cormac. @biology.ox.ac.uk academic.oup.com/bioinformati...
academic.oup.com
HI-FEVER: a Nextflow pipeline for the high-throughput discovery and annotation of endogenous viral elements
AbstractSummary. Endogenous viral elements (EVEs) offer valuable insights into virus and host evolution, but their detection remains computationally and bi
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Eric Topol @erictopol.bsky.social · 08/01/2026
Here's a summary of all the data that supports adding more red meat to your diet
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Paris Marx @parismarx.com · 04/01/2026
Given everything happening right now, I updated this article with options for weather apps, web forms, and translation services — along with some tweaks to existing categories. I hope it helps your transition off US tech!
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Eric Topol @erictopol.bsky.social · 01/01/2026
New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...
science.org
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
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EMDB @emdatabank.bsky.social · 18/12/2025
The EMDB wishes you a very Merry Christmas, a Happy New Year and we are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, we look forward to seeing you in the New Year here! Card: A mixture of #cryoEM and X-ray diffraction structures.
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Marija Backovic @marijabackovic.bsky.social · 17/12/2025
Seven feel-good science stories to restore your faith in 2025 www.nature.com/articles/d41...
nature.com
Seven feel-good science stories to restore your faith in 2025
Immense progress in gene-editing, drug discovery and conservation are just some of the reasons to be cheerful about 2025.
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Max Planck Institute for Molecular Genetics @molgen.mpg.de · 27/11/2025
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD? Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool! 👉 www.molgen.mpg.de/5094682/Fuey...
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The American Academy of Pediatrics @ameracadpeds.bsky.social · 05/12/2025
The decision by the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention to downgrade its recommendations to protect infants from hepatitis B is a dangerous move that will harm children. Click here to read AAP's full statement: bit.ly/3Y9ZQJT
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Harry Low’s Lab @lowlab.bsky.social · 05/12/2025
Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
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Marija Backovic @marijabackovic.bsky.social · 04/12/2025
Special kudos to @thomasbourgeron.bsky.social and authors for writing up the ⭐ FAQ section ⭐ accessible to general audience 👏 👏 For those interested, the FAQs are in the Supplement to their article, section 8 (page 59), downloadable via the link already posted. An example of a question addressed 👇
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thomasbourgeron.bsky.social @thomasbourgeron.bsky.social · 03/12/2025
#4/5 This work has been made possible thanks to the participants and to the help of the Autism Representative (A Reps) from @AIMS 2 Trials 🙏. A FAQ 📋 has been added to explain the main results of the paper. Follow us on @aims2trials.bsky.social and @r2d2mh.bsky.social MH for more information 🗣️!
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thomasbourgeron.bsky.social @thomasbourgeron.bsky.social · 03/12/2025
#5/5 Find out more here: www.medrxiv.org/content/10.1... Declan Murphy, Eva Loth, @tonycharman.bsky.social, @vw1 @mathisfleury.bsky.social @zmougin.bsky.social @pasteur.fr @upcite.bsky.social @gisautismetnd.bsky.social
medrxiv.org
LEAP-InovAND a multiscale resource to explore genetics, brain imaging and clinical data in autism
Most current autism research focuses on categorical comparisons (e.g., autistic vs. neurotypical people) and usually examines only one biological domain (e.g., cognition, genetics, or brain imaging). ...
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thomasbourgeron.bsky.social @thomasbourgeron.bsky.social · 03/12/2025
#1/5 Our new study is out in medRxiv. It is a major collaborative effort that brought together researchers and experts by experience from across Europe, including psychologists 🧠, psychiatrists 👩‍⚕️, geneticists 🧬, neuroscientists 🔬, and, importantly, autistic people 🌈, relatives 👪 and caregivers 🤝.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 02/12/2025
Interesting! I have been teaching the multiple origins of viruses since 1983, I will point out...😁 www.the-scientist.com/where-do-vir...
the-scientist.com
Where Do Viruses Come From?
Using genomics, evolutionary biologists test several hypotheses on the origin of viruses. New evidence suggests they may have emerged more times than previously thought.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 03/12/2025
In fact, I even have a useful illustration, from The Good Book.
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