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María Angélica Bravo Núñez

@mariangebravo.bsky.social
1.3K followers 511 following 24 posts

HHMI Hanna Gray Fellow and Assistant Professor at @CornellMBG studying the evolution and molecular mechanisms of chromosome segregation in fungi 🍄| PhD @ScienceStowers | she/her | 🇲🇽

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Reposted by María Angélica Bravo Núñez
Journal of Cell Biology @jcb.org · 16/09/2026
Avl9 defines a family of DENN domain GTPase-activating proteins. New study from Ryan C. Vignogna (@rvig.bsky.social) & J. Christopher Fromme (@fromme-lab.bsky.social) @cornelluniversity.bsky.social: rupress.org/jcb/article/... #GolgiTime #GTPases #Migration #Biochemistry #StructuralBiology #Golgi
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rachellcosby.bsky.social @rachellcosby.bsky.social · 16/09/2026
Infertility affects ~1 in 6 people, and up to 30% of cases are unexplained. I am excited to present my postdoctoral work from @toddmacfarlan.bsky.social 's lab, now available as a preprint: tinyurl.com/yync6f2r addressing a possible role for the meiotic gene PRDM9 in infertility 🧵/1
Link to preprint titled: "PRDM9-mediated meiotic hotspot specification is constrained in humans despite extensive sequence diversity"
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Reposted by María Angélica Bravo Núñez
Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 13/09/2026
Fascinating stuff - Acquisition and erosion of toxin-antitoxin systems in bacterial chromosomes academic.oup.com/mbe/advance-...
academic.oup.com
Acquisition and erosion of toxin-antitoxin systems in bacterial chromosomes
Abstract. Toxin-antitoxin systems (TAs) are widespread in bacterial genomes. Yet, their integration, persistence, and impact in chromosome dynamics remain
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Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 12/09/2026
📣 We’re hiring! The Weill Institute for Cell and Molecular Biology and the Department of Biomedical & Translational Sciences are seeking a tenure-track Assistant Professor in Molecular Therapeutics. 🔬 Review begins November 15, 2026
apps.hr.cornell.edu
Academic Career Opportunities
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Paul Rainey @paulbrainey.bsky.social · 07/09/2026
A beautiful piece of detective work by @honour.bsky.social + colleagues revealing the origins of Ralstonia disease of bananas on Martinique. As so often, ICEs (ICERs!) prove to be extraordinary capacitors for evolutionary change. Evolution for evolution's sake 🤔 doi.org/10.1093/gbe/...
doi.org
Interspecies Exchange of Mobile Genetic Elements During a Plant Disease Outbreak
Abstract. Outbreak sequencing provides insight into the origin and evolutionary processes acting on emerging pathogens. Sequencing a historic multihost out
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Richa Sardana @richasardana.bsky.social · 03/09/2026
Happy to see this story out- led by graduate student, Julia Zhu, where she uncovers that the yeast homolog of Cystinosin, Ers1, functions in redox homeostasis at the early-Golgi! Thanks to everyone who contributed, and, hopefully, more to come! www.molbiolcell.org/doi/10.1091/...
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Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 02/09/2026
We're pleased to welcome Dr. Edgar Medina Tovar to @weillinstitute.bsky.social and @cornelluniversity.bsky.social! Edgar brings an exciting research program exploring cellular evolution and fungal pathogenesis, and we’re thrilled to have him join our community. Looking forward to what's ahead! 🔬 🍄‍🟫 🍄
news.cornell.edu
Medina Tovar joins Weill Institute to study cellular evolution, pathogenesis of fungi | Cornell Chronicle
Edgar Medina Tovar joins the Weill Institute for Cell and Molecular Biology and the College of Arts & Sciences as an assistant research professor in September. He will begin as an assistant professor ...
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Damian Dudka @damiandudka.bsky.social · 17/07/2026
My lab just opened at Lehigh University - we study the origins, mechanisms, and impacts of the rapid evolution of the chromosome segregation machinery. I'm looking for 2 team members (postdoc and lab tech) who are passionate about evolution and cell division! See the opportunities at dudkalab.me.
dudkalab.me
Dudka Lab — Home
The Dudka Lab at Lehigh University studies how rapid evolution of chromosome segregation machinery impacts health, fertility, and disease.
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Peiwei Chen @peiwei-chen.bsky.social · 17/07/2026
How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...
biorxiv.org
piRNA loss unleashes episodic transposition bursts
In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon ex...
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Jana Helsen @helsenjana.bsky.social · 16/07/2026
I am starting my lab at the University of Geneva next January! Incredibly excited to soon be joining the MOCEL department as an Asst. Professor. The lab will use evolutionary cell biology to study chromosomes, centromeres & speciation 🧬🔬🌱 Intrigued, want to join or collaborate? 🔗 helsenlab.org
helsenlab.org
Helsen lab | chromosome and centromere evolution
The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...
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Shiv Grewal @grewalsh.bsky.social · 08/07/2026
Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...
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Danny Miller, MD, PhD @danrdanny.bsky.social · 06/07/2026
Hi everyone! I'm excited to announce that our lab at UW will soon be recruiting a postdoc to work on DNA methylation signatures in rare disease. This will be a mostly computational position. Please share and reach out if interested! millerlaboratory.com
millerlaboratory.com
Miller Lab | University of Washington
Led by Danny E. Miller, MD, PhD, the Miller Lab uses long-read Nanopore sequencing to investigate the significance of structural genomic variation, methylation, and RNA in human disease, and to impro...
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Kevin Forsberg @kvnforsberg.bsky.social · 02/07/2026
Humans and bacteria share strategies to defend against viruses. We wondered: could they use each other's genes? Yes, both can! Bacteria can use human immune genes to defend against phages AND Human cells can use bacterial genes for viral defense. www.biorxiv.org/content/10.6...
biorxiv.org
Bacterial and human exonucleases mediate interkingdom antiviral immunity
All kingdoms of life have developed strategies to limit viral infection. In humans, interferons induce a suite of antiviral factors that collectively provide immunity. Some human immune genes are homo...
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Reposted by María Angélica Bravo Núñez
Tina Termini @cterminiphd.bsky.social · 23/06/2026
Congratulations to the 8th cohort of @fredhutch.org Dr. Eddie Méndez scholars! Co-directing this program is one of my favorite part of the job. We are excited to welcome you to Fred Hutch later this summer to share your research with our scientific community. www.fredhutch.org/en/news/rele...
fredhutch.org
Fred Hutch names 8 recipients of the Dr. Eddie Méndez Award
Fred Hutch names eight recipients of the Dr. Eddie Méndez Award, which celebrates early-career scientists' research in cancer, infectious disease and basic sciences.
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María Angélica Bravo Núñez @mariangebravo.bsky.social · 16/06/2026
CONGRATS @stevenssostre.bsky.social !!!! 💫💫💫💫💫🤩🤩🤩🤩
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Leading Edge Fellows Program @leadingedgeprogram.bsky.social · 09/06/2026
We are thrilled to announce the 2026 Zara Weinberg Leading Edge Fellows! 40 remarkable postdocs pursuing transformative research in biological/biomedical sciences. This is the 7th Leading Edge cohort and we are so excited to welcome them! www.leadingedgesymposium.org/fellows/
Congratulations to the 2026 Zara Weinberg Leading Edge Fellows! 
Airi Yoshimoto, Yijun Yang, Alexandra Wells, Simran Virdi, Archana Venkataraman, Emery Usher, Marianna Tannus Ruckert, Wenzhi Song, Kathryn Shelley, Selin Schamiloglu, Julia Peloggia de Castro, Ines Patop, Ruhi Patel, Suranjana Pal, Bernie Simone Owusu Yaw, LaShae Nicholson, Sivapratha Nagappan Chettiar, Dallas Mould, Jessica Moore, Deka Mohamed, Sierra Marable, Annie Ly, Xi (Lucy) Lu, Deirdre Logsdon, Anna Lipkin, Ellen Lesser, Mia Konjikusic, Veronika Kondev, Cayla Jewett, Lucia Ichino, Erin Huiting, Maggie Horst, Isabella Gaeta, Martha Echevarria-Andino, Natasha Claxton, Sarah Cherkaoui, Nikita Bhalerao, Merci Best, Meenakshi Asokan, Alicer Andrew
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brookscrickard1.bsky.social @brookscrickard1.bsky.social · 02/06/2026
Here is a link to my student Mitch's final published paper on the activity of Rad51 and Rad54 during the homology search. genesdev.cshlp.org/content/40/1...
genesdev.cshlp.org
The eukaryotic homology search complex distorts donor DNA structure to probe for homology
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
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Reposted by María Angélica Bravo Núñez
Adrienne Roeder Lab @roederlab.bsky.social · 30/05/2026
Check out our paper in the @PNASNews Special Feature: bit.ly/PNASpoly. We explore how stress induces polyploidy across fungi, plants, and animals, reshaping genomes, cells, and tissues through cell cycle alterations. Great collaboration with Don Fox and @annaselmecki.bsky.social.
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Reposted by María Angélica Bravo Núñez
Cedric Feschotte @cedricfeschotte.bsky.social · 29/05/2026
📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com
thefeschottelabatcornell.com
The Feschotte Lab at Cornell
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Patrick S. Mitchell @psmitchej.bsky.social · 25/05/2026
Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 12/05/2026
Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast www.biorxiv.org/content/10.64898/20…
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Molly Schumer @mollyschumer.bsky.social · 12/05/2026
Excited to share this new pre-print from the fantastic @kelsiehunnicutt.bsky.social! Kelsie put together a thoughtful and thorough review on hybridization in animal evolution: ecoevorxiv.org/repository/v.... She tracks notable shifts in perspectives on the study of hybridization through time.
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Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 07/05/2026
👨‍🔬 🔬 🧠 How do we better understand, and ultimately fight, neurodegenerative disease? Grad student Nicolas Vergara Ruiz is tackling that question through his research in Weill Institute's Han lab. His story highlights the passion, perseverance, and curiosity behind scientific discovery. Read more:
wicmb.cornell.edu
Opening the box: Nicolas Vergara Ruiz and the fight against neurodegenerative disease – Weill Institute for Cell and Molecular Biology
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Reposted by María Angélica Bravo Núñez
PLOS Biology @plosbiology.org · 06/05/2026
How does the fungal pathogen #Cryptococcus neoformans adapt to the high #CarbonDioxide levels found in the human body? This study shows that CO₂ tolerance depends on coordinated metabolic, oxidative & membrane remodeling, partly via TOR–Ypk1 signaling @plosbiology.org 🧪 plos.io/3RmnKSc
Proposed model integrating metabolic, ROS, and membrane stresses and their responses under host CO2 concentrations. Red arrows indicate CO2-related stress, and blue arrows indicate CO2 stress adaptive or compensatory responses. Created in BioRender.com. Ristow, L. (2026)
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Tera Levin @teralevin.bsky.social · 02/05/2026
Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how? Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/
Microscopy image showing yeast cells expressing a fluorescently tagged version of the amoeba TirC protein. TirC forms filaments that span the yeast cells.
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Peiwei Chen @peiwei-chen.bsky.social · 17/04/2026
plz repost 🙏 we are looking for a technician to start this summer/fall for 1-2 years to work with me at Cornell in the labs of @cedricfeschotte.bsky.social and Andy Clark, in collaboration with @corriemoreau.bsky.social on flies & termites 🪰🐜🧬🔬 Ithaca is gorges! jobs.hr.cornell.edu/us/en/job/WD...
jobs.hr.cornell.edu
CALS- Technician I- Molecular Biology and Genetics in Ithaca, New York, United States of America | Research & Instructional Support at Cornell University
Apply for CALS- Technician I- Molecular Biology and Genetics job with Cornell University in Ithaca, New York, United States of America. Research & Instructional Support at Cornell University
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María Angélica Bravo Núñez @mariangebravo.bsky.social · 17/04/2026
WOOOO! Congrats, @heatherfeaga.bsky.social!!! @cornelluniversity.bsky.social
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Jason Stajich @hyphaltip.bsky.social · 11/04/2026
Check out Hannah Reid's new album 🍄🎻 with some spoken words by Fungi Foundation's Giuliana Furci www.hannahread.com/vol-2
hannahread.com
Vol. 2 | Explore Fungi-Inspired Music - Listen Today — Hannah Read
Discover Hannah Read's Fungi Sessions Vol. 2, a nature-inspired album blending folk and experiential sounds, available April 10, 2026. Stream and pre-order now.
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brookscrickard1.bsky.social @brookscrickard1.bsky.social · 08/04/2026
Very exciting that our new paper on the forces exerted by the Rad51-Rad54 homology search complex is now online. This was a collaborative effort with the Wang here at Cornell, and this work performed primarily by a graduate student, Mitch Woodhouse genesdev.cshlp.org/content/earl...
genesdev.cshlp.org
The eukaryotic homology search complex distorts donor DNA structure to probe for homology
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
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Cohen Lab @Cornell @cohenlab.bsky.social · 08/04/2026
Very proud of this tour de force from two former students, Stephanie Tanis and Leah Simon, with help from a huge team, including @charlesdanko.bsky.social highlighting a novel-overlooked intervention point for male contraception www.pnas.org/doi/10.1073/...
pnas.org
Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1 | PNAS
Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transientl...
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Iva Tolić @ivatolic.bsky.social · 28/03/2026
Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @natcomms.nature.com, here's a thread 🧵 shorturl.at/OD89x
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Anurag Agrawal @anurag-asclepias.bsky.social · 26/03/2026
Open postdoc position in my lab at Cornell, conducting comparative and experimental studies on transcriptomic responses to diet and toxins, utilizing the milkweed-insect community. Background in molecular bio & herbivory desired. academicjobsonline.org/ajo/jobs/31867
academicjobsonline.org
Cornell University, CALS Ecology and Evolutionary Biology
Job #AJO31867, WDR-00057721 Postdoctoral Associate, CALS Ecology and Evolutionary Biology, Cornell University, Ithaca, New York, US
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Genetics Society of America @genetics-gsa.bsky.social · 18/03/2026
A new study in #GENETICS from @monica-pradillo.bsky.social and colleagues uncovers a key role for the plant-specific nuclear basket nucleoporin NUP1/NUP136 in chromosomal interactions and crossover formation in #Arabidopsis. buff.ly/zo8JHLi
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Takashi Akera Lab @takashiakeralab.bsky.social · 07/03/2026
Congrats Duilio on discovering the 1st Toxin-Antidote system in vertebrates! 🎉He single-handedly established the embryo project in my lab!👍
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Katie Billmyre @katiebillmyre.bsky.social · 05/03/2026
Wanted to advertise the presentations from my lab occurring at #Dros26! It’s my first time getting to bring my trainees and can’t wait for them to share their work.
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Peiwei Chen @peiwei-chen.bsky.social · 04/03/2026
What happens if the germline goes on without (most of the) piRNAs for 45 generations? Come find out at my talk at the evolution session on Saturday at #dros26 @genetics-gsa.bsky.social 🪰🔬🔎⁉️🤔
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Mia Levine @levine-lab.bsky.social · 23/02/2026
So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...
biorxiv.org
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Daniela Robles-Espinoza @daniela-oaks.bsky.social · 18/02/2026
We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...
nature.com
Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature
Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...
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Liedewij Laan @liedewijlaan.bsky.social · 22/02/2026
And another paper! We show that compensatory evolution in the yeast polarity network leads to global genetic rewiring: restoring polarity reshapes gene disruption tolerance across the genome and rewires entire cellular processes—not just individual genes. doi.org/10.1038/s44319-026-00709-4
doi.org
Global genetic rewiring during compensatory evolution in the yeast polarity network - EMBO Reports
Functional defects resulting from deleterious mutations can often be restored during evolution by compensatory mutations. Importantly, this process can generate the genetic diversity seen in networks ...
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Cahir O'Kane @cahirokane.bsky.social · 16/02/2026
Aspergillus fumigatus - 29.9 crossovers per homologous chromosome pair! That makes about 1500 recombination map units per chromosome....
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Vaughn Cooper @vscooper.micropopbio.org · 16/02/2026
🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...
biorxiv.org
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Adrienne Roeder Lab @roederlab.bsky.social · 14/02/2026
A Postdoctoral Associate position is available in the Roeder Laboratory at Cornell University in Ithaca, NY with a focus on researching Polyploidy. Apply by March 1. Please spread the word. apps.hr.cornell.edu/recruiting/f...
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Sophien Kamoun @kamounlab.bsky.social · 13/02/2026
Vorholt Lab re-created endosymbiosis in the lab: injected bacteria into a fungus and evolved a heritable partnership. Evolution, fast-forwarded. doi.org/10.1038/s415...
doi.org
Inducing novel endosymbioses by implanting bacteria in fungi - Nature
A study presents an approach to establish and track a new endosymbiotic partnership by implanting bacteria in a non-host fungus and shows that stable inheritance of the implanted bacteria is possible ...
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Molly Przeworski @mollyprz.bsky.social · 12/02/2026
The program for the 2026 New York Population Genetics meeting, hosted by at the @simonsfoundation.org on March 9th 2026, is now up: events.simonsfoundation.org/event/7c91dd....
events.simonsfoundation.org
NY Population Genetics meeting
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MsEE Lab @mseelab.org · 11/02/2026
Where does the idea of a PhD come from? What from its history can we return to as we attempt to define or redefine it? Notes from Pablo on the MsEE Lab substack as graduate school admissions season rolls along. open.substack.com/pub/mseelab/...
open.substack.com
What is a PhD?
Why should "teacher" mark the pinnacle of knowledge?
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André Marques @amarques.bsky.social · 27/01/2026
A new extreme of meiotic evolution: ✔️ 𝗻𝗼 crossovers ✔️ 𝗻𝗼 gene conversion ✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴. more about it: www.biorxiv.org/content/10.6...
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PLOS Biology @plosbiology.org · 26/01/2026
Ferns alternate between asexual #sporophyte & sexual free-living #gametophyte. This study uncovers the mechanism of male-to- #hermaphrodite conversion in the #fern #Ceratopteris, revealing a novel role for #auxin biosynthesis during #meristem formation @plosbiology.org 🧪 plos.io/4k5EcAU
Auxin signaling dynamics during Ceratopteris male development in response to antheridiogen. The six panels contain confocal time-lapse images showing auxin signaling dynamics in Ceratopteris male gametophytes expressing the DR5v2::ntdTomato transgenic reporter, grown on conditioned fern medium. A male gametophyte was live-imaged every day from 1 to 6 days after germination (DAG). The panels show projection views of tdTomato signals (Fire LUT). The white arrowhead (top left panel) indicates the initial DR5 signal in the early developing prothallus, while yellow arrowheads (top row) indicate DR5 signals in developing rhizoids. Cyan arrowheads and white dashed circles highlight DR5 signaling dynamics during antheridium initiation and maturation. Color bars represent the relative intensity of DR5 signals in Fire LUT images, with low intensity shown in black, intermediate intensity in blue to red, and high intensity in yellow to white. The color scale applies to the entire prothallus but excludes the spore coat. Scale bars: 50 µm.
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Jackson Ridges @jacksonridges.bsky.social · 24/01/2026
Check out our new paper, out in the current issue of Proc B! In this work, we investigate the long-term persistence of the Drosophila pseudoobscura SR chromosome without suppression. We reconstruct its evolutionary history, showing that it has a history of suppression and escape from suppression.
doi.org
Drive, suppression and escape from suppression of a selfish chromosome
Abstract. Meiotic drivers are selfish genetic elements that are predicted to spark rapid intra-genomic arms races with their suppressors. However, the long
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Steffi (she/her) @sillysciencelady.bsky.social · 23/01/2026
My second PhD project is now out as a preprint! Our observations of the synaptonemal complex in wild-type Nematostella suggested an incredible degree of conservation. Then, our mutants told a story of dramatic functional divergence. We were bamboozled on a regular basis with this one! 🧪 #meiosis4eva
biorxiv.org
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