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Jackson Ridges

@jacksonridges.bsky.social
66 followers 106 following 4 posts

PhD Student in the Phadnis Lab at the University of Utah

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Reposted by Jackson Ridges
Genetics Society of America @genetics-gsa.bsky.social · 01/09/2026
🪰 A new study in #GENETICS demonstrates how the Stellate meiotic drive system in #Drosophila is active in contemporary populations, revealing its evolutionary significance. 🔗 buff.ly/UqEQJrQ
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James Gagnon @james-gagnon.bsky.social · 04/08/2026
In a new (ish) preprint, we used CRISPR barcodes to label germline stem cell clones in zebrafish, then tracked their contributions to sperm production for 2 years. Instead of staying stable, individual clones rose, fell, and disappeared over time. www.biorxiv.org/content/10.6...
biorxiv.org
Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis
Spermatogonial stem cells (SSCs) maintain male fertility, but how their clonal dynamics change with age remains poorly understood. Here, we use in vivo CRISPR barcoding in zebrafish to label SSCs and ...
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Reposted by Jackson Ridges
Genetics Society of America @genetics-gsa.bsky.social · 31/07/2026
🪰 The latest #Drosophila study in #GENETICS characterizes genetic factors contributing to drive strength in a sample of inbred lines, providing novel insights into the complex dynamics of Segregation Distorter chromosomes and their suppressors. 🔗 buff.ly/1FkZ5zq
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Emmanuel Gonzalez-Sqalli @gonzalez-sqalli.bsky.social · 14/07/2026
Very happy to share that our study on macroH2A in Gryllus bimaculatus 🦗 is now published in @pnas.org ! 🎉 This work, central to my PhD thesis, uses endogenous KI, KO, and deletion of the non-histone region to explore what macroH2A does in vivo in an invertebrate. www.pnas.org/doi/10.1073/...
6 days after-egg-laying cricket embryo. F-actin in cyan, neurons in yellow, macroH2A-V5 in magenta.
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Mark A. Hanson @hansonmark.bsky.social · 08/03/2025
This #InternationalWomensDay I want to tell the story of Lilian Vaughan Morgan. I learned of Lilian this past year - what a badass. Lilian was a leading scientist when women weren't welcome in the lab, nor even the department. But she contributed immensely to the genetics of sex determination 1/n
A photo of a young Lilian Vaughan Morgan, sitting with a book on her lab staring into the distance.A photo of an older Lilian Vaughan Morgan, sitting at a lab bench with a microscope and dozens of glass milk bottles bunged with cotton. Lilian is in the middle of applying ether to anaesthetize a bottle of flies.
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Peiwei Chen @peiwei-chen.bsky.social · 04/03/2026
What happens if the germline goes on without (most of the) piRNAs for 45 generations? Come find out at my talk at the evolution session on Saturday at #dros26 @genetics-gsa.bsky.social 🪰🔬🔎⁉️🤔
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Reposted by Jackson Ridges
Arvid Ågren @arvidagren.bsky.social · 27/02/2026
Nature News on the tantalising possibility of the first documented sex-ratio distorter in humans. www.nature.com/articles/d41...
nature.com
Is a ‘selfish gene’ making a Utah family have twice as many boys as girls?
Genealogy study claims first conclusive case of sex ‘distortion’ in humans — but not all researchers are convinced.
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Reposted by Jackson Ridges
Mia Levine @levine-lab.bsky.social · 23/02/2026
So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...
biorxiv.org
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Julius Brennecke @juliusbrennecke.bsky.social · 13/02/2026
The demystification of piRNA clusters if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read check out @86dominik.bsky.social's opus magna (or Dominik's great thread) a shared project with the one and only Rippei Hayashi, lab alumnus & friend
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Dominik Handler @86dominik.bsky.social · 13/02/2026
How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 10/02/2026
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements www.biorxiv.org/content/10.64898/20…
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Greg Copenhaver @copenhaverlab.bsky.social · 06/02/2026
Our (@jeffsekelsky.bsky.social, Corbin Jones & me) #Meiosis, Recombination & Evolution of Sex class @uncchapelhill.bsky.social had a great chat w/ Kent Golic @uofubiology.bsky.social about his lab's #GENETICS paper on #Drosophila ring chromosomes: doi.org/10.1093/gene...
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 08/02/2026
Signatures of sex ratio distortion in humans www.biorxiv.org/content/10.64898/20…
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Genetics Society of America @genetics-gsa.bsky.social · 02/02/2026
In #GENETICS, @hildeschneemann.bsky.social and John Welch introduce a simple fitness landscape model to predict hybrid fitness with arbitrary ploidy and an arbitrary number of hybridizing lineages using data from #maize and rye. buff.ly/E24fZsM
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Cécile Courret @cecilecourret.bsky.social · 24/10/2025
I'm thrilled to announce that I’m opening my own research team in the Department of Genome Biology at I2BC @i2bcparissaclay.bsky.social ! #ATIP-Avenir Very excited to start this new adventure! www.i2bc.paris-saclay.fr/equipe-intra...
i2bc.paris-saclay.fr
Equipe Courret – Institute for Integrative Biology of the Cell
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Arvid Ågren @arvidagren.bsky.social · 26/01/2026
The Paradox of the Organism in the university news case.edu/news/medicin...
case.edu
Medicine’s J. Arvid Ågren examines how organisms persist with internal conflicts | CWRU Newsroom | Case Western Reserve University
J. Arvid Ågren, PhD, assistant professor at Cleveland Clinic Lerner College of Medicine, and Manus M. Patten, teaching professor at Georgetown Univer...
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Reposted by Jackson Ridges
Emiliano Martí 🇦🇷 @emilianomarti.bsky.social · 27/01/2026
Meiotic drive has long been considered as a genetic curiosity. Genomic "footprints" suggest otherwise. Check out our new review doi.org/10.1093/molb..., a cross-taxa synthesis arguing that recurrent drive is a pervasive and underappreciated force in genome evolution.
doi.org
The Evolutionary Genomics of Meiotic Drive
Abstract. Meiotic drivers are selfish genetic elements that gain transmission advantages by distorting equal, Mendelian segregation. For decades, biologist
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Jackson Ridges @jacksonridges.bsky.social · 24/01/2026
Check out our new paper, out in the current issue of Proc B! In this work, we investigate the long-term persistence of the Drosophila pseudoobscura SR chromosome without suppression. We reconstruct its evolutionary history, showing that it has a history of suppression and escape from suppression.
doi.org
Drive, suppression and escape from suppression of a selfish chromosome
Abstract. Meiotic drivers are selfish genetic elements that are predicted to spark rapid intra-genomic arms races with their suppressors. However, the long
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fly paper broadcast @fly-broadcast.bsky.social · 21/01/2026
Drive, suppression and escape from suppression of a selfish chromosome #Drosophila
pubmed.ncbi.nlm.nih.gov
Drive, suppression and escape from suppression of a selfish chromosome #Drosophila
PubMed link
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Jackson Ridges @jacksonridges.bsky.social · 11/01/2026
Check out our new paper in early access at Nature Communications! www.nature.com/articles/s41...
nature.com
Client Challenge
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 10/08/2025
Drive, suppression, and escape from suppression of a selfish chromosome www.biorxiv.org/content/10.1101/202…
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