Sign in

Ryan Vignogna

@rvig.bsky.social
44 followers 35 following 14 posts

Postdoc @fromme-lab.bsky.social | Heja BVB

PostsRepliesMedia
Reposted by Ryan Vignogna
Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 09/09/2026
@weillinstitute.bsky.social adventures with AI from @fromme-lab.bsky.social! @rvig.bsky.social and colleagues used AI to uncover a previously unknown class of cellular “off switches” that regulate protein trafficking, revealing new insights into pathways linked to cancer cell movement and disease.
news.cornell.edu
AI reveals new class of cellular ‘off switch’ linked to cancer pathways | Cornell Chronicle
Cornell researchers have used artificial intelligence to uncover a previously unknown way cells control how proteins move inside them, a process essential for growth, communication and movement, and o...
021
Ryan Vignogna @rvig.bsky.social · 09/09/2026
🎉 Our DENN GAP paper is now out in JCB! Some exciting new results were added since the preprint, including the discovery that yeast and human AVL9 differ in substrate specificity. rupress.org/jcb/article/...
rupress.org
Avl9 defines a family of DENN domain GTPase-activating proteins
Using computational protein–protein interaction screens, Vignogna and Fromme identify Avl9 as a GTPase-activating protein for Arf-family GTPases. They demo
184
Ryan Vignogna @rvig.bsky.social · 06/01/2026
Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: www.biorxiv.org/content/10.6...
biorxiv.org
Avl9 defines a family of GTPase-activating proteins that regulate diverse cell biological functions
Ras-related GTPases are molecular switches regulating hundreds of signaling and trafficking pathways in cells. Many GTPase regulators remain to be identified despite extensive genetic and biochemical ...
1175
Reposted by Ryan Vignogna
Fromme Lab @fromme-lab.bsky.social · 04/12/2024
Excited to share the published version of our work by @ryanfeathers.bsky.social and @rvig.bsky.social on the structural basis for activation of Rab6 by the Ric1-Rgp1 complex! rdcu.be/d2mu3 Here is an updated thread about the paper we first shared on that older platform when we posted the preprint
1398