iiinova — where your digital self keeps evolving

LinderLab @linderlab.bsky.social · 05/10/2026

Congratulations to our lab member Konstantin Sopelniak for a superior disputation of his work on phagocytosis of Borrelia and Candida by human macrophages👨‍🎓

Konstantin Sopelniak with his elaborate doctor hat

Konstantin and his examiners after his successful disputation

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LinderLab @linderlab.bsky.social · 25/09/2026

Next stop: Meeting of the German Society for Hygiene and Microbiology dghm-kongress.de

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LinderLab @linderlab.bsky.social · 09/09/2026

The lab visiting the Monet exhibition at Port de Lumières in Hamburg 🎨

Members of the LinderLab in front of a projection showing part of a Monet painting

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LinderLab @linderlab.bsky.social · 08/09/2026

The LinderLab reflecting on itself 🪞

Members of the LinderLab and their reflections in a mirrored elevator

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LinderLab @linderlab.bsky.social · 03/09/2026

Our lab member Fan Yang giving a super nice talk about Borrelia outer membrane vesicles (OMVs) at the Extracellular Vesicles Workshop in Hamburg 🦠

Fan Yang giving a talk, with the Power Point presentation in the background

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LinderLab @linderlab.bsky.social · 26/08/2026

Our lab member Canberk Yesilada giving an excellent talk on Borrelia phagocytosis by human macrophages at the Nordinfect Symposium 🎤

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LinderLab @linderlab.bsky.social · 26/08/2026

Proudly presenting posters at the Nordinfect Symposium in Hamburg 👍

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LinderLab @linderlab.bsky.social · 18/08/2026

Happy to report that the collaborative publication with the Windhorst and Marlovits groups has been selected as Paper of the Month (PoM) at the University Medical Center Hamburg-Eppendorf 👍

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LinderLab @linderlab.bsky.social · 06/07/2026

An evolutionarily conserved, short linear actin filament-binding motif (SFM), present in >100 proteins. Great collaboration with the Windhorst and Marlovits labs. Happy to have contributed, by using macrophage podosomes as a readout. Publication in Nat Cell Biol: www.nature.com/articles/s41...

Immunofluoresence image of primary human macrophage expressing the GFP-fused SFM of ARHGEF11, with ROIs of several and single podosomes. Association of the SFM with the F-actin core of podosomes, stained by phalloidin, shown by Poji macro analysis on the right.

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LinderLab @linderlab.bsky.social · 23/03/2026

Podosomes in phagocytosis! 😋 + Candida auris Our new paper "Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages" has now been published in Cell Reports: pubmed.ncbi.nlm.nih.gov/41863801/

C. auris-associated phagocytic podosomes share components and substructures with their “classic”, ECM-associated counterparts. Detected substructures and components include an F-actin-rich core (positive for Arp2 and cortactin), a cap structure on top of the core (positive for -actinin, zyxin, LSP1), a ring structure mediating adhesion to the phagocytic particle (containing vinculin, talin-1,  integrin), and a base near the plasma membrane (containing myosin 1f, WASp, MT1-MMP, DNAse X, and enriched in phospho-tyrosine residues). Individual phagocytic podosomes are linked by actomyosin filaments, similar to the connecting cables of ventral podosomes, thus establishing a flexible podosome array on phagosomes. The high turnover rate of phagocytic podosomes likely enables dynamic restructuring of the nascent phagocytic cup. In combination with establishing close adhesion to the pathogen surface, this likely mediates efficient internalization of C. auris cells in macrophages. Recruitment of degradative enzymes such as MT1-MMP or DNase X could, directly or indirectly, contribute to phagosome maturation and particle degradation.

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LinderLab @linderlab.bsky.social · 13/03/2026

Podosomes in endocytosis! 🔬 Check out our new preprint "Drebrin forms a cortical hub that connects actin, microtubules, and clathrin for endocytic transport of β2 integrin" www.biorxiv.org/content/10.6...

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LinderLab @linderlab.bsky.social · 23/01/2026

New publication: Live Biological Imaging Across Scales 10 chapters on live imaging from molecules to organisms, written by leading experts and edited by Claire Wells and yours truly Can now be pre-ordered by your online or brick-and-mortar vendor of choice 🔬

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LinderLab @linderlab.bsky.social · 17/11/2025

A warm welcome to our new PhD student Emma Lautenbach, who will work on the intricacies of the podosome cap 🧢

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LinderLab @linderlab.bsky.social · 11/11/2025

A warm welcome to our new lab member Canberk Yesilada, who will be/is already working on his PhD thesis on Borrelia phagocytosis by macrophages 🤗

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LinderLab @linderlab.bsky.social · 07/11/2025

Macrophages are super! SoRA (superresolution after optical reassignment) microscopy video of a primary human macrophage transfected with Lifeact-GFP to visualize actin-rich podosomes. Star-like appearance is due to connecting cables linking individual podosomes into a cell-wide superstructure ✨

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LinderLab @linderlab.bsky.social · 26/10/2025

On our way to Heidelberg to the meeting of the German Society for Cell Biology 🧫

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LinderLab @linderlab.bsky.social · 15/09/2025

New preprint: Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages 🦠👄 www.biorxiv.org/content/10.1...

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LinderLab @linderlab.bsky.social · 02/09/2025

Our paper on podosome regulation by myosins 1e/f is now online. We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬 Cool collaboration with @renaudpoincloux.bsky.social‬ and Krendel labs www.sciencedirect.com/science/arti...

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LinderLab @linderlab.bsky.social · 26/08/2025

Congratulations to our lab member Bryan Barcelona to a super fancy defense on software-based analysis of cell and podosome parameters 👨‍🎓

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LinderLab @linderlab.bsky.social · 09/07/2025

Cellular fireworks (in a primary human macrophage): Microtubule +tips, labeled by CLIP170-GFP, move from the microtubule organizing center (MTOC) to the cell periphery ✨

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LinderLab @linderlab.bsky.social · 04/07/2025

A warm welcome to our new master student Mahmood Tarmom, who will work on podosome proteins of (yet) unknown function 🔬

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LinderLab @linderlab.bsky.social · 23/06/2025

Coming up: "Live Biological Imaging Across Scales", part of the Royal Microscopic Society line of Wiley books. Featuring 10 chapters from international experts on live imaging from molecules to organisms. Edited by Claire M. Wells and yours truly 📘🧬🐭

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LinderLab @linderlab.bsky.social · 30/04/2025

Our preprint on podosome regulation by unconventional myosins in now on BioRxiv. Great collaboration with the @renaudpoincloux.bsky.social and Krendel labs. www.biorxiv.org/content/10.1... We introduce the concept of the "podosome base", a region of plasma membrane-associated podosome components.

Myo1e (green) shows a more ventral localization than the F-actin core (red) of podosomes. XZ side view of two podosomes.

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LinderLab @linderlab.bsky.social · 09/04/2025

Upcoming meeting: 11th Trippenhuis meeting of the Dutch Society for Cell Biology (Amsterdam, May 8-9) 🏠

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LinderLab @linderlab.bsky.social · 01/04/2025

Farewell sushi dinner for our longtime assistant Andrea who is now retiring 🥲🍣

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LinderLab @linderlab.bsky.social · 10/03/2025

Congratulations to our lab member Rawan Batlouni for an excellent MD thesis on phagocytic podosomes 👨‍🎓

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LinderLab @linderlab.bsky.social · 26/02/2025

A warm welcome to our new MD student Fan Yang, who will work on Borrelia-macrophage interaction 🤗

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LinderLab @linderlab.bsky.social · 21/02/2025

Video of a FIB-SEM analysed macrophage phagosome containing a single Borrelia cell being compacted by membrane tubulation, leading to reduction of the phagosome volume. Phagosome membrane in blue, Borrelia in turquoise. Watch for start of transparency mid-video 🪱 pubmed.ncbi.nlm.nih.gov/33380490/

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