Second-generation C-to-N swap turns the first generation’s failure into a feature

Alt: Jackson Pollock Drip Painting

Second-generation C-to-N swap turns the first generation’s failure into a feature

Second-generation C-to-N swap turns the first generation’s failure into a feature

Despite recent proof-of-concept advances, aromatic carbon-to-nitrogen replacement reactions remain substrate specific and exhibit an overreliance on harsh oxidation methods that preclude their deploym...

The University of Chicago is a private, nondenominational, culturally rich and ethnically diverse coeducational research university located in Hyde Park, Chicago.

SAN FRANCISCO, CA—Anthropic announced an expansion of their new AI for Science initiative Thursday in the hope that helping cure diseases might make people feel warmly toward the artificial…

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The winners are being acknowledged for their outstanding achievements in chemistry across various fields in the discipline

Oxygen-to-carbon swap expands synthesis options for 5-membered aromatics

A one-pot skeletal-editing reaction replaces isoxazole oxygen with carbon to form challenging pyrroles, enabled by an N-propargylic enaminone intermediate and a computational model predicting reaction outcomes.

Nature Chemistry, Published online: 18 August 2026; doi:10.1038/s41557-026-02231-5The α-arylation of carbonyl compounds remains a central challenge in chemical synthesis. Now it has been shown that BisTrip, a recyclable aryl group transporter, enables rapid and regiospecific α-arylation of diverse carbonyl compounds, providing access to challenging arylated ketones including quaternary carbon centres within intricate molecules.

sHenning Hopf, retired Professor of Organic Chemistry at the Technical University of Braunschweig, passed away on March 12, 2026. He will be remembered not only for his groundbreaking contributions t....

Alt: The gigantic gyroscope-like structure from the movie Contact (1997).

It’s bad for your brain and worse for democracy.