The development of Shono-type oxidation reactions for late-stage functionalization has recently focused on the expansion of compatible nucleophiles; however, a central limitation is N-aryl, or aniline...

A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox-neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used ...

The University of Chicago is a private, nondenominational, culturally rich and ethnically diverse coeducational research university located in Hyde Park, Chicago.

The winners are being acknowledged for their outstanding achievements in chemistry across various fields in the discipline

University of Chicago-led institute will advance quantum sensors toward robust tools for revealing biological processes beyond the reach of conventional measurement

Research outlines a new workflow for design and manufacturing, illustrated by two new methane-fighting materials.

Colloidal gallium nitride and titanium nitride nanocrystals could enable printed displays and implant coatings

Aberrant protein-protein interactions (PPIs) drive myriad diseases. Inhibiting these PPIs often relies on discovering molecules that bind to one of the proteins and hoping that this binding inhibits t...

Abstract. Whereas molybdenum-dependent hydroxylases in the xanthine oxidase family catalyze site-selective C–H hydroxylation reactions using terminal molyb

Dr. Abdoulaye Djire has been selected as a recipient of the prestigious Camille Dreyfus Teacher-Scholar Award, a national honor recognizing exceptional early-career faculty.

An international award for research and technological innovation in the energy and environmental fields.

Direct deaminative cyanation of aliphatic amines is hampered by inert C–N bonds and oxidative instability. Now a copper-catalysed, preactivation-free approach enabled by anomeric amide activation is r...

Faculty have a responsibility to protect classrooms as a training ground for thinking, and proliferating LLMs endanger this core mission of the University.

A (tBu,TolDHP)Cu complex is reported as an electrocatalyst for alkyne semihydrogenation and carbonyl reduction. Mechanistic investigations reveal the catalyst proceeds through intermediates where the ...

Today I want to reflect on departmental seminars, which are getting harder for me to attend for work/life balance reasons I’ll explain below.

Recent advances have made possible the replacement of individual atoms within a molecular skeleton while preserving the integrity of the surrounding framework. These skeletal editing reactions are emerging as powerful tools for molecular optimization, as they directly mirror tactics central to structure–activity-relationship studies and therefore have the potential to accelerate progress in discovery chemistry settings. This review introduces a comprehensive framework for categorizing atom replacement reactions in aromatic systems, while also delineating strategies that enable these transformations. Important heuristics related to shape-conservation are discussed, including notions of skeletal rotation, introduction of vestigial substituents, and retrosynthetic simplicity. Examples of reactions which obey these principles are analyzed, focusing first on C-to-N replacement in aromatic systems (“benzene to pyridine” and related reactions) before moving to other classes of aromatic and aliphatic replacement reactions.

The nickel-containing carbon monoxide dehydrogenase (CODH) uses a unique heterometallic [NiFe4S4] cluster active site, called the C-cluster, to catalyze the reversible reduction of carbon dioxide (CO2...

Developing molecules that selectively bind targets of interest remains a critical bottleneck in biological research and biotechnology. Here, we present a workflow that leverages the Phage-Assisted Non-Continuous Selection for Binders (PANCS-Binders) technology for rapid de novo binder discovery. To directly assess the speed and utility of the approach, we pursued three cancer-related targets: NSD3, NMNAT2, and CSF1R. Within 26 days, the PANCS-Binders workflow yielded sequence- and function-verified binders for all three targets with nano-to-micromolar affinities. By incorporating an NSD3 binder into an engineered E3 ligase, RNF8, we developed an NSD3 degrader that potently depleted endogenous NSD3 and inhibited colorectal cancer cell proliferation. We then applied this degrader to reveal previously unknown NSD3 dependencies in ovarian cancer cell lines, uncovering new therapeutic vulnerabilities. Together, our work establishes a robust workflow for accelerated binder discovery and demonstrates how binders can expedite chemical biology discovery and biotechnology development.

Two UChicago scientists elected to National Academy of Sciences in 2026 Apr 30, 2026 Two University of Chicago scholars have been elected to the National Academy of Sciences, joining other scientists and researchers chosen in “recognition of their distinguished and continuing achievements in origina…