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Mark Levin

@levinchem.bsky.social
2.6K followers 981 following 260 posts

Professor of Chemistry University of Chicago Single-Atom Skeletal Editing Husband, Dad, Crossword Addict levingroup.uchicago.edu According to at least one colleague: "clinging to the past"

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Mark Levin @levinchem.bsky.social · 25/09/2026
I am not doing them any favors
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Mark Levin @levinchem.bsky.social · 21/09/2026
Applications to the UChicago PhD program are open! chemistry.uchicago.edu/graduate-pro... Please check out the information sessions too - anyone who *registers* *and* *attends* an info session will get a fee waiver code sent to them after the session!
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Mark Levin @levinchem.bsky.social · 02/09/2026
Sorry, but this part doesn't pass the sniff test - if this were true, they wouldn't be building the data centers!
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Mark Levin @levinchem.bsky.social · 19/08/2026
What is the heterocyclic variant of carbonyl olefination? Today we report isoxazole-to-pyrrole O-to-C replacement - check out the full story here: www.nature.com/articles/s41...
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Mark Levin @levinchem.bsky.social · 12/08/2026
The Anthropic logo looks exactly like Kurt Vonnegut's drawing from Breakfast of Champions
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Mark Levin @levinchem.bsky.social · 04/08/2026
It's giving
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Mark Levin @levinchem.bsky.social · 04/08/2026
This well-meaning article falls into a familiar trap - after detailing how AI is failing on scale in her role as CIO, the author credulously asserts thats it does work for drug discovery. www.nytimes.com/2026/08/03/o... Reminds me of this: inpreparation.substack.com/p/scientists...
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Mark Levin @levinchem.bsky.social · 29/07/2026
⌛
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Mark Levin @levinchem.bsky.social · 24/07/2026
This is customer service for "go away"
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Mark Levin @levinchem.bsky.social · 15/07/2026
🫩 www.theatlantic.com/technology/2...
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Mark Levin @levinchem.bsky.social · 30/06/2026
lmao, just what we need - ten 100-page reviews written without human involvement, great idea folks
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Mark Levin @levinchem.bsky.social · 29/06/2026
I am tickled by this ACS email as someone whose most common registration approach in previous ACS's was to forget to register until I try to pick up my badge and then register on-site. lol @ "gentle reminder" and "we understand" Guess most speakers "forgot"?
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Mark Levin @levinchem.bsky.social · 03/06/2026
I am particularly proud of this classification scheme, which I hope will become a blueprint for the field as people continue to go after these important C-to-N replacement reactions!
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Mark Levin @levinchem.bsky.social · 13/01/2026
Today on @chemrxiv.org, we disclose a C-to-N replacement that actually works complex natural products - a pipe-dream when we started. The secret is to lean in to the triplet nitrene. Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi! chemrxiv.org/engage/chemr...
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Mark Levin @levinchem.bsky.social · 30/12/2025
Just in time for the new year - we show that you can make either isomer of N-aryl pyrazole selectively from a single TDSO. We really believe in the power of these wacky heterocycles. chemrxiv.org/engage/chemr... Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J
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Mark Levin @levinchem.bsky.social · 07/12/2025
Every morning while making coffee www.poetryfoundation.org/poetrymagazi...
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Mark Levin @levinchem.bsky.social · 25/11/2025
God I wish it was only because of DOGE
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Mark Levin @levinchem.bsky.social · 21/10/2025
A true pleasure to host Koji Kubota @uchichemistry.bsky.social for a stop on his Merck Banyu Lectureship Award Tour!
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Mark Levin @levinchem.bsky.social · 21/10/2025
New @chemrxiv.org, a collaboration with @honggen-wang.bsky.social and group alum, now asst prof. Myojeong Kim: the first true catalytic interception of isodiazene-generated primary-amine-derived radicals. The key is an N-F reagent that enables productive chain carrying! doi.org/10.26434/che...
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Mark Levin @levinchem.bsky.social · 24/09/2025
😵😵😵😵
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Mark Levin @levinchem.bsky.social · 18/09/2025
🚨FEE WAIVERS!🚨 Sign up for our info sessions on Nov. 4 and Nov. 11th - anyone who registers and attends will get an application fee waiver! chemistry.uchicago.edu/graduate-pro...
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Mark Levin @levinchem.bsky.social · 18/08/2025
If you're at ACS this Wednesday, come by my talk at 2:05 PM in the East Salon A, part of the joint ORGN/AGRO symposium on accelerating discovery and development!
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Mark Levin @levinchem.bsky.social · 09/08/2025
It still can't electron push - here are some of it's attempts at peracid epoxidation. The text description of the mechanism is not bad, but not perfect. Seems unable to connect that to images
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Mark Levin @levinchem.bsky.social · 08/08/2025
It's really trying
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Mark Levin @levinchem.bsky.social · 08/08/2025
Here is what happens with more prodding to use the (mostly correct) text description of the mechanism to "design it explicitly in chemical drawing software logic" Second image is after it asked me if I wanted it to "refine further"
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Mark Levin @levinchem.bsky.social · 08/08/2025
lol @ PhD's in my pocket - still can't electron push 🤷‍♂️
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Mark Levin @levinchem.bsky.social · 18/07/2025
Today in @science.org, @mikusp.bsky.social reports a method to replace the C2 of pyridines with N, affording pyridazines. The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter. www.science.org/doi/10.1126/...
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Mark Levin @levinchem.bsky.social · 28/05/2025
Fans of Guenther Schlonk will enjoy the "cross-decoupling" easter egg: jabde.com/wp-content/u...
A "cross-decoupling" or "retro-Suzuki" sequence
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Mark Levin @levinchem.bsky.social · 14/04/2025
M. Gessen hits the nail on the head, yet again www.nytimes.com/2025/04/14/o...
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Mark Levin @levinchem.bsky.social · 03/04/2025
You'll soon be able to purchase the key aminating reagent - watch this space!
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Mark Levin @levinchem.bsky.social · 03/04/2025
If you're interested in a break from the doom-and-gloom, may I recommend our article, online today @nature.com A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage! www.nature.com/articles/s41...
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Mark Levin @levinchem.bsky.social · 18/03/2025
It's finally in the Federal Register! 2 months late is better than never!
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Mark Levin @levinchem.bsky.social · 23/02/2025
This is supposed to be a visual proof of the Pythagorean theorem (you spin and it drains into the other squares), but @msichicago.bsky.social can't seem to get the fill level right - two photos, ~1 year apart
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Mark Levin @levinchem.bsky.social · 23/02/2025
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Mark Levin @levinchem.bsky.social · 22/02/2025
Indeed
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Mark Levin @levinchem.bsky.social · 20/02/2025
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Mark Levin @levinchem.bsky.social · 10/02/2025
This passage from Derek captures the insanity of these past few weeks so much better than I could ever articulate
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Mark Levin @levinchem.bsky.social · 18/11/2024
Alexandra Petri has been putting a brilliant voice to my frustrations these past few weeks. Her column is (maybe unfortunately) a must-read these days.
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Mark Levin @levinchem.bsky.social · 12/11/2024
Now online as an accepted article, a novel hypervalent iodine reagent that functions as a source of electrophilic "N". My first student, Patrick Kelly's swan song (now a postdoc with the Stahl lab), done in collaboration with scientists at GSK. onlinelibrary.wiley.com/doi/10.1002/...
TOC image describing the DNIBX reagent
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Mark Levin @levinchem.bsky.social · 23/10/2023
I have gotten in the habit of sending something like this to my coauthors everytime we submit - the last mile stuff (final experiments, waiting for reviews, revisions) can be such a slog that it's easy to forget to celebrate.
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Mark Levin @levinchem.bsky.social · 28/09/2023
The problem I started my lab to work on. Not the end of the story, but a huge first step from @tylerpearson.bsky.social Replace an aromatic carbon atom with no perturbation of the rest of the skeleton - if you put the azide in with C-H functionalization, you can scan positions on a parent arene.
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