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L-type pyocins are a class of bacteriocin-like proteins with antibacterial activity. Here, the authors show that these proteins kill the pathogen Pseudomonas aeruginosa by inhibiting the BAM complex a...

β-mannans are plant structural and storage polysaccharides prevalent in the human diet. Their degradation in the gastrointestinal tract is mediated by the human gut microbiota (HGM) through expression...

Structures of the heterodimeric ATP-binding cassette (ABC) transporter TM287/288 have previously been determined in several states indicating large conformational changes during its reaction cycle. Ho...

Iron is an essential element that can be growth-limiting in microbial communities, particularly those present within host organisms. To acquire iro...

PhD Project - Resolving the mechanism of Mycobacterium tuberculosis antibiotic tolerance through single-molecule microscopy at Newcastle University, listed on FindAPhD.com

PhD Project - Hiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University, listed on FindAPhD.com

PhD Project - C. difficile S-layer’s role in antimicrobial resistance at Newcastle University, listed on FindAPhD.com

PhD Project - Molecular mechanisms of siderophore-mediated iron uptake in Fungi at Newcastle University, listed on FindAPhD.com

PhD Project - Forged by Iron: Synthetic protein binders to decode bacterial iron transport mechanisms at Newcastle University, listed on FindAPhD.com

PhD Project - Nutrient uptake in commensal bacteria: exploring uncharacterised TonB-dependent transporters. at Newcastle University, listed on FindAPhD.com

PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates

PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com