Greg Chojnowski @gchojnowski.bsky.social · 31/03/2026Two homologous proteins were independently solved using cryo-EM. The high-resolution structure is correct but incomplete; the lower-resolution structure has a hard-to-spot error. Only together do they provide a complete picture! 030
Reposted by Greg ChojnowskiMatthias Wilmanns @matthiaswilmanns.bsky.social · 03/09/2025We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5. Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1 1186
Reposted by Greg ChojnowskiTVP World @tvpworld.bsky.social · 19/04/2025Today marks the 82nd anniversary of the Warsaw Ghetto Uprising, recognized as the largest act of armed resistance undertaken by Jews during WWII. Launched against insurmountable odds, the rebellion is often cited as one of the defining moments in modern Jewish history.tvpworld.com82 years since the Warsaw Ghetto UprisingThe doomed Uprising led to the complete annihilation of Jewish Warsaw. 25327
Greg Chojnowski @gchojnowski.bsky.social · 15/02/2025www.goodreads.com/quotes/99381... a grim reflection on the past and a projection of the future that has just arrived.goodreads.comA quote from A People’s History of the United StatesThe problem of democracy in the post-Revolutionary society was not, however, the Constitutional limitations on voting. It lay deeper, beyond the Constitu... 010
Greg Chojnowski @gchojnowski.bsky.social · 08/02/2025High time to understand what's going on in there. Sadly, the historian's perspective is as depressing as that of Faulkner, Steinbeck or Bukowski. 010
Greg Chojnowski @gchojnowski.bsky.social · 06/02/2025I’m happy to share gapTrick, an AlphaFold2-based tool for characterising protein-protein complexes www.biorxiv.org/content/10.1...biorxiv.orggapTrick - Structural characterisation of protein-protein interactions using AlphaFold with multimeric templatesThe structural characterisation of protein-protein interactions is a key step in understanding the functions of living cells. Models of protein complexes provide important insights into interaction me... 153
Greg Chojnowski @gchojnowski.bsky.social · 01/02/2025The book doesn't really explain why we sleep, but the message is very simple and convincing: "Go the f*k to sleep!". Highly recommended (the book too). 000
Reposted by Greg ChojnowskiRandy Read 🇨🇦🇬🇧 @randyjread.bsky.social · 18/01/2025This might be a good opportunity to remind people that experimental data (diffraction or cryoEM maps) have to be provided with the submission of papers to the IUCr society journals on Structural Biology, Acta Cryst D and F. So referees don’t even have to ask any more! 3198
Reposted by Greg Chojnowskijankosinski.bsky.social @jankosinski.bsky.social · 04/12/2024We have released version 2 of AlphaPulldown - a general pipeline for high-throughput structural modeling! Software: github.com/KosinskiLab/... Preprint: biorxiv.org/content/10.1... 1309
Reposted by Greg ChojnowskiEMBL @embl.org · 21/11/2024EMBL is Europe’s life sciences laboratory. 🧬🧪 At our sites in Barcelona, Grenoble, Hamburg, Heidelberg, Hinxton, and Rome, we seek to understand life in context, from molecules to ecosystems. 🔬🌍 Follow us for our latest news and updates about research, training, services and more. www.embl.orgembl.orgEuropean Molecular Biology LaboratoryWith 29 member states, laboratories at six locations across Europe and thousands of scientists and engineers working together, the European Molecular Biology Laboratory is a powerhouse of biological e... 06221
Reposted by Greg ChojnowskiArjen Jakobi @cryotud.bsky.social · 18/11/2024Really looking forward to welcoming & meeting the participants of our #EMBOStructBio course this morning! Many of our speakers/tutors are here: @moalquraishi.bsky.social @sykhalid.bsky.social @ezgikaraca.bsky.social @amjjbonvin.bsky.social @gchojnowski.bsky.social @drmelissagraewert.bsky.social 0288
Reposted by Greg ChojnowskiMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 15/11/2024New GPU-based MMseqs2: 20x faster searches on a single L40S (approx. as fast as a RTX 4090) vs. a 128-core CPU. This work enables to set up a very cost-efficient ColabFold MSA GPU server. 🧵🧵 📄 www.biorxiv.org/content/10.1... 💾 mmseqs.com 🗞️ developer.nvidia.com/blog/boost-a... 217359
Reposted by Greg ChojnowskiStructural Biology @actacrystd.iucr.org · 14/11/2024How many of the PDB models that were solved using experimental phasing could have been solved by molecular replacement using models obtained from AlphaFold? #MolecularReplacement #AlphaFold2 #ComputationalMethods t.co/s6EahtcYms 192