Reposted by Rhys WhiteASM @aussocmic.bsky.social · 28/09/2026The latest issue of Microbiology Australia is now online! connectsci.au/ma/issue/47/3 145
Rhys White @rhystwhite.bsky.social · 27/09/2026When genomic surveillance stops at the bacterial lineage, what do we miss? Spanning within-host vanB E. faecium, to a drug-susceptible K. variicola NICU outbreak, & MRSA AK3. See what resolving mobile DNA can add to investigations doi.org/10.1071/MA26... 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠doi.orgMobile DNA as epidemiological engines: lessons from New ZealandAntimicrobial resistance (AMR) is one of the biggest global public health threats of the 21st Century, yet it often spreads in ways that routine surveillan 163
Reposted by Rhys WhiteGeorge Bouras @gbouras13.bsky.social · 07/08/2026If you are looking for web-based phage annotation, phage-annotation.org is live. Upload a genome to run Pharokka, Phold and Phynteny sequentially (see our recent protocols paper doi.org/10.1002/cpz1...). If you have feedback, please reach out Thanks to @ardc.edu.au for making this possible!phage-annotation.orgPhage Annotation Server -- phage genome annotationFree automated phage genome annotation -- pharokka, phold and phynteny in one pipeline. 46130
Rhys White @rhystwhite.bsky.social · 30/07/2026Removing coordinate-defined regions from phylogenomic matrices is simple in principle, but editing errors can alter the matrix. NEXCISION provides exact, validated excision from transposed NEXUS matrices 🔗 github.com/RhysWhite/ne... Feedback welcome #Bioinformatics 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠github.comGitHub - RhysWhite/nexcision: Precise region-based excision of coordinate-labelled rows from NEXUS matrices.Precise region-based excision of coordinate-labelled rows from NEXUS matrices. - RhysWhite/nexcision 054
Rhys White @rhystwhite.bsky.social · 08/05/2026We’re using @nanoporetech.com in a frontline lab 157 K. pneumoniae genomes later: No evidence of patient-patient transmission 👉connected genomics👈 Frontline WGS, linked with national public health & bioinformatics expertise www.doi.org/10.1099/mgen... 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠 1113
Rhys White @rhystwhite.bsky.social · 13/02/2026Long-reads exposed plasmid-driven carbapenem resistance transmission missed by routine diagnostics 📌Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing www.doi.org/10.1099/mgen.0.001644 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠doi.orgResolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencingThe growing resistance of Enterobacterales to last-resort antibiotics such as carbapenems puts a significant burden on healthcare systems, also due to plasmids driving a rapid spread of carbapenem res... 0106
Rhys White @rhystwhite.bsky.social · 22/01/2026It’s 2026. If you submit a #Genomics paper without making the underlying sequence data publicly available, reproducibility is... 👉I M P O S S I B L E👈 #OpenScience data isn’t optional. It’s foundational to #PublicHealth, benchmarking & scientific credibility 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠media.tenor.comFine This Is Fine GIFALT: Fine This Is Fine GIF 180
Rhys White @rhystwhite.bsky.social · 14/01/2026From a neonatal ICU in Wellington to clinics in Africa & Europe: a new Global Health Now feature shows how onsite @nanoporetech.com sequencing is shaping #InfectionPrevention… helping deliver answers in hours not weeks - turning #Genomic into real-world action 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠 072
Rhys White @rhystwhite.bsky.social · 05/01/2026🧵BIG PROBLEMS can hide in small #Plasmids 📌Integration of blaOXA-48 into a Col156 plasmid drove a carbapenem-resistant Escherichia coli ST131 outbreak in New Zealand: Global genomic evidence for the gene’s multilayered dissemination doi.org/10.1016/j.dr... 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠doi.orgRedirecting 3112
Rhys White @rhystwhite.bsky.social · 11/11/2025Genomics isn’t just solving #Outbreaks, it’s stopping them before they escalate HOT take from @natrevmicro.nature.com: If you only sequence #MDR outbreaks, you’re already late. Consider susceptible strains & #Plasmids #GenomicSurveillance #InfectionControl 🖥️🧬💻 #AcademicSky #MicroSky #IDSky 🧪🧫🦠 1195
Rhys White @rhystwhite.bsky.social · 03/11/2025⚠️ What is measles (Te mate karawaka)? A HIGHLY contagious virus that spreads through the air. People are infectious before the rash shows Learn more 👉 info.health.nz/conditions-t... 😷💉 #Measles #MMR #VaccinesWork #Aotearoa #PublicHealth 251
Rhys White @rhystwhite.bsky.social · 02/11/2025Measles in #NZ Check locations & what to do👉 info.health.nz/conditions-t... Symptoms or exposure? ☎️Call Healthline 0800 611 116 Not immune? Get MMR (2 doses, 1 month apart) Book👉 app.bookmyvaccine.health.nz #Measles #MMR #VaccinesWork #Aotearoa #PublicHealthinfo.health.nz 033
Rhys White @rhystwhite.bsky.social · 29/09/2025🚨New paper out! Why does Staphylococcus aureus ST1 dominate in BOTH people🧑⚕️ & cows🐄 in New Zealand… but rarely elsewhere? Our latest comparative genomics study unpacks this mystery👇 📄 doi.org/10.1128/msph... @asm.org #AMR #Genomics #OneHealth 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠doi.orgComparative genomics of endemic Staphylococcus aureus ST1 in New Zealand | mSphereThis study presents a comprehensive genomic analysis of S. aureus ST1, a lineage that is unusually dominant in both bovine and human populations in New Zealand. Leveraging New Zealand’s geographical i... 1113
Rhys White @rhystwhite.bsky.social · 11/09/2025🚨Call for abstracts #OneHealth Aotearoa Symposium 2025 📍Wellington + online 🗓️2–3 Dec 2025 Submit an abstract by 30 Sept Themes: #AMR, #Zoonoses, #HealthEquity, #TeAoMāori, #ClimateHealth & more More info👉 onehealth.org.nz/one-health-a... 📩one.health@otago.ac.nz 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠onehealth.org.nzOne Health Aotearoa Symposium 2025 - One Health AotearoaOur 11th annual symposium will be held on 2-3 December 2025 at the University of Otago, Wellington campus and online. Registrations will open soon! Venue Information Nordmeyer Lecture Theatre – Univer... 053
Rhys White @rhystwhite.bsky.social · 04/09/2025Honoured to present this at #MicroSeq2025💙 This work reflects contributions from MANY colleagues across institutions & I'm grateful for the opportunity to share it Published in @microbiologysociety.org: doi.org/10.1099/mgen... Also in @aunz.theconversation.com: theconversation.com/antibiotic-u...doi.org20 years later: unravelling the genomic success of New Zealand’s home-grown AK3 community-associated methicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureus (MRSA) represents a significant public health challenge. In New Zealand, the community-associated MRSA sequence type (ST)5, carrying the staphylococcal cass... 031
Rhys White @rhystwhite.bsky.social · 18/08/2025New Zealand’s prescribing habits likely helped create a homegrown #MRSA 🇳🇿🧬💊 Now ‘AK3’ has been detected overseas Our recent study shows how it evolved & how #Genomics can help reduce the impact of the next ‘superbug’ #AMR is an issue for everyone #SciComm 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠 02212
Rhys White @rhystwhite.bsky.social · 12/08/2025💥How New Zealand's previous 'go-to' #Antibiotic fuelled the rise of a home-grown #MRSA superbug By the 2010s, AK3 took the lead as NZ’s top #MRSA strain, fuelled by years of high fusidic acid use #AntibioticResistance #PublicHealth doi.org/10.1099/mgen... 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠doi.org20 years later: unravelling the genomic success of New Zealand’s home-grown AK3 community-associated methicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureus (MRSA) represents a significant public health challenge. In New Zealand, the community-associated MRSA sequence type (ST)5, carrying the staphylococcal cass... 073
Rhys White @rhystwhite.bsky.social · 07/08/2025Peer-reviewed evidence that @nanoporetech.com & #DoradoCorrect (HERRO) can resolve a NICU #MRSA outbreak to SNV precision - no short reads needed (so long as adequate n50 read lengths are met) Fast, decentralised, clinically useful 🔗 doi.org/10.1016/j.jh... #Genomics #PHFScience #InfectionControldoi.orgRedirecting 020
Reposted by Rhys WhiteJames Connolly @ruamicro.bsky.social · 30/07/2025Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.nature.comConvergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature CommunicationsCottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ... 13417
Rhys White @rhystwhite.bsky.social · 11/07/2025Out & #OpenAccess 📌Community outbreak of OXA-48–producing Escherichia coli linked to food premises, New Zealand, 2018-2022 doi.org/10.3201/eid3... Thanks to folks across NZ who helped investigate & respond #AMR #PublicHealth #Genomics #Epidemiology #Scicomm 🧵 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠doi.orgCommunity Outbreak of OXA-48–Producing <em>Escherichia coli</em> Linked to Food Premises, New Zealand, 2018–2022Outbreak of OXA-48–Producing <em>E. coli</em>, New Zealand 174
Rhys White @rhystwhite.bsky.social · 21/05/2025One patient, two samples Weeks apart, E. faecium picked up vancomycin resistance By sequencing vancomycin-susceptible strains on-site, we caught this early & avoided unnecessary, disruptive interventions #Genomics Proud to share at #nanoporeconf! @nanoporetech.com 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠 0245
Rhys White @rhystwhite.bsky.social · 13/04/2025Attending #ESCMIDGlobal & curious about community-associated CPE? Craig Thornley is presenting today on a prolonged OXA-48-producing E. coli cluster in New Zealand, with genomic evidence supporting community & hospital transmission. See poster E0434 #ESCMIDGlobal2025 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠 080
Rhys White @rhystwhite.bsky.social · 06/03/2025Hospital infections are a problem & 'go-to' methods have limits. We trailed @nanoporetech.com in outbreak detection & response 📌Implementing nanopore sequencing in a clinical laboratory: a social systems case study | NZ J Med Lab Sci issuu.com/sharontozer/... 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠issuu.comNZJMLS V.79 N0. 1 March 2025New Zealand Journal of Medical Laboratory Science. Volume 79, Number 1, March 2025 1106
Rhys White @rhystwhite.bsky.social · 13/02/2025📌The need for speed: ultra-rapid high-resolution outbreak analysis in a front-line hospital microbiology laboratory |@medrxivpreprint See how hospital labs can analyse outbreaks fast - no on-site #Bioinformatics needed, cutting delays doi.org/10.1101/2025... 🖥️🧬💻 #AcademicSky #MicroSky 🧪🧫🦠doi.orgThe need for speed: ultra-rapid high-resolution outbreak analysis in a front-line hospital microbiology laboratoryMany hospital laboratories have technical capacity to perform whole-genome sequencing but lack bioinformatic expertise to analyse sequence data. Sending isolates to reference laboratories creates dela... 52411
Rhys White @rhystwhite.bsky.social · 11/02/2025K. variicola can be misID as K. pneumoniae. Our #OpenAccess paper reports an NICU #Outbreak 📌The rapid detection of a neonatal unit outbreak of a wild-type Klebsiella variicola using decentralized Oxford Nanopore sequencing doi.org/10.1186/s137... @nanoporetech.com 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠doi.orgThe rapid detection of a neonatal unit outbreak of a wild-type Klebsiella variicola using decentralized Oxford Nanopore sequencing - Antimicrobial Resistance & Infection ControlBackground Klebsiella variicola has been implicated in neonatal intensive care unit (NICU) outbreaks previously and can be misidentified as Klebsiella pneumoniae. An increased incidence of K. pneumoni... 0103
Reposted by Rhys WhiteMichelle Wille @duckswabber.bsky.social · 04/12/2024Amazing work by the NZ MPI team - the full genome from the HPAI H7N6 detection is now available on GISAID. Further information on the impacts and control actions can be found here: bit.ly/4iy3O8nbit.lySituation update H7N6 bird flu detection Otago – 4 December 2024 | NZ GovernmentBiosecurity New Zealand is taking further action today to stamp out a high pathogenic strain of avian influenza, H7N6, detected on a commercial egg farm in rural Otago. "Work started this morning to h... 13711
Rhys White @rhystwhite.bsky.social · 27/11/2024Kia ora koutou! 👋 I’ve put together a starter pack of amazing people working in #Genomics across Aotearoa New Zealand. If I’ve missed anyone, please let me know! go.bsky.app/KhMbQxK 1236
Reposted by Rhys White🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 25/11/2024NEW Publication!😄 Here, we show how #PhyKIT — a broadly applicable toolkit for #phylogenomics — can be used to construct phylogenomic data matrices (& quantify biases therein), detect anomalies in predicted orthology, calculate gene-gene coevolution, & more! 🔗: tinyurl.com/yc5ja4xz 216363
Rhys White @rhystwhite.bsky.social · 23/11/2024Day 6 of @who.int World #AntimicrobialAwarenessWeek: AMR isn't just a global crisis—it has local consequences🌏 It’s not just about humans. #AMR affects animals, the environment & everything in between. To truly understand AMR, we need to see how these 3 are connected #OneHealth #WAAW🧵👇🧪 #WAAW2024 2152
Rhys White @rhystwhite.bsky.social · 22/11/2024Day 5 of the @who.int World #AntimicrobialAwarenessWeek. We've covered what #AntibioticResistance is & how it spreads. But how do bacteria resist #Antibiotics? From modifying drug targets to producing enzymes that break down antibiotics, here are some common #AMR mechanisms🧵🧪 #WAAW #WAAW2024 172
Rhys White @rhystwhite.bsky.social · 21/11/2024Day 4 of the @who.int World #AntimicrobialAwarenessWeek: Composite transposons are another way #AntimicrobialResistance genes spread. These ‘jumping genes’ move resistance genes within & between bacterial DNA, increasing bacterial resistance to #Antibiotics! 🧵👇 #WAAW2024 #AMR 🧪 1135
Rhys White @rhystwhite.bsky.social · 20/11/2024Day 3 of the @who-global.bsky.social World #AntimicrobialAwarenessWeek: Did you know that viruses called phages can also spread #AntimicrobialResistance? A phage can infect bacteria & can sometimes transfer #AMR genes between them. Let’s see how! 🧵👇 🧪 #WAAW2024 11910
Rhys White @rhystwhite.bsky.social · 19/11/2024It's day 2 of the @who-global.bsky.social World #AntimicrobialAwarenessWeek: How does #AntimicrobialResistance spread between bacteria? Let’s explore how #plasmids, tiny DNA molecules, can transfer resistance genes across bacteria—even different species in some cases! 🧵👇 🧪 #WAAW #AMR 2195
Rhys White @rhystwhite.bsky.social · 19/11/2024Welcome to Day 1 of the @who-global.bsky.social World #AntimicrobialAwarenessWeek! Today, let’s break down what antimicrobial resistance is & why it’s a threat to New Zealand & the world 🧵👇 #WAAW2024 #WAAW #AMR 🧪 174
Rhys White @rhystwhite.bsky.social · 10/11/2024Proactive nanopore WGS in the NICU can detect & help contain bacterial outbreaks early, protecting newborns Genome sequencing developed to trace COVID is now protecting babies in intensive care from infectious diseases theconversation.com/genome-seque... via @theconversation.bsky.social #IDSkytheconversation.comGenome sequencing developed to trace COVID is now protecting babies in intensive care from infectious diseasesInfectious disease control in neonatal units is often reactive, only after several babies fall ill at the same time. Proactive genome sequencing provides an early-warning system to prevent outbreaks. 1106
Rhys White @rhystwhite.bsky.social · 08/11/2024A partial E. coli genome assembly was recovered from a diseased Kākāpō 🤯 ExPEC, ST141, 02/050 O-antigen serogroup 010
Rhys White @rhystwhite.bsky.social · 01/11/2024#COVID update for New Zealand - XEC variant (detected 8 Sept) now established, showing 3% daily growth advantage over dominant KP.3.1.1 - Growth rate is slower than JN.1's previous 10% advantage - WHO has designated XEC as Variant Under Monitoring🔍 2154
Reposted by Rhys WhiteWillem van Schaik @wvschaik.bsky.social · 24/10/2024This is amazing and important work by Glen Carter and colleagues at the University of Melbourne 'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus' www.nature.com/articles/s41...nature.comRifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin - NatureRifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin. 11712
Rhys White @rhystwhite.bsky.social · 03/10/2024📌The rapid detection of a neonatal unit outbreak of a wild-type Klebsiella variicola using decentralized Oxford Nanopore sequencing - 48hr turnaround (Nanopore) - Accessible #Genomics for hospitals - Ability to catch subtle outbreaks DOI: doi.org/10.21203/rs.... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠doi.orgThe rapid detection of a neonatal unit outbreak of a wild-type Klebsiella variicola using decentralized Oxford Nanopore sequencingBackground Klebsiella variicola has been implicated in neonatal intensive care unit (NICU) outbreaks previously and can be misidentified as Klebsiella pneumoniae. An increased incidence of K. pneumon... 020
Rhys White @rhystwhite.bsky.social · 23/09/2024Early bird registration is open #OHA2024 10th #OneHealth Aotearoa Symposium 📅3-4 Dec 2024 📍University of Otago Wellington 💻In-person & online Key speakers & themes on #AntimicrobialResistance, climate change, Te Ao Māori & more Link www.otago.ac.nz/conference/o... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠 010
Rhys White @rhystwhite.bsky.social · 18/09/2024Bluesky now has over 10 million users, and I was #1,378,954! 010
Rhys White @rhystwhite.bsky.social · 29/07/2024🚨 Call for Abstracts! 🚨 One Health Aotearoa invites submissions for the #OneHealth Aotearoa Symposium 2024! 📆 3-4 December 📍University of Otago Submit your 250-word abstract by 31 August 2024 to one.health@otago.ac.nz Don't miss out! #Research #Collaboration 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠 020
Rhys White @rhystwhite.bsky.social · 13/07/2024New short comm out in preprint! 📌Resolving a neonatal intensive care unit outbreak of methicillin-resistant Staphylococcus aureus to the SNV level using Oxford @nanopore simplex reads and HERRO error correction | @biorxivpreprint.bsky.social doi.org/10.1101/2024... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠doi.orgResolving a neonatal intensive care unit outbreak of methicillin-resistant Staphylococcus aureus to the SNV level using Oxford Nanopore simplex reads and HERRO error correctionbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 222
Rhys White @rhystwhite.bsky.social · 06/07/2024Exciting news! Our latest #OpenAccess paper is out now 📌Rapid identification and subsequent contextualization of an outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit using nanopore sequencing doi.org/10.1099/mgen... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠doi.orgRapid identification and subsequent contextualization of an outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit using nanopore sequencingOutbreaks of methicillin-resistant Staphylococcus aureus (MRSA) are well described in the neonatal intensive care unit (NICU) setting. Genomics has revolutionized the investigation of such outbreaks; ... 162
Rhys White @rhystwhite.bsky.social · 07/05/2024Super proud of our latest #OpenAccess paper: 📌Early identification of a ward-based outbreak of Clostridioides difficile using prospective multilocus sequence type-based Oxford Nanopore genomic surveillance | @ICHEJournal @nanopore doi.org/10.1017/ice.... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠doi.orgEarly identification of a ward-based outbreak of Clostridioides difficile using prospective multilocus sequence type-based Oxford Nanopore genomic surveillance | Infection Control & Hospital Epide...Early identification of a ward-based outbreak of Clostridioides difficile using prospective multilocus sequence type-based Oxford Nanopore genomic surveillance 142
Rhys White @rhystwhite.bsky.social · 22/04/2024April’s #COVID19 update: - JN.1 & decedents dominate ~98% of sequenced cases - JN.1.11.1 is the fastest growing lineage in New Zealand at present - #Wastewater confirms JN.1 takeover See more👉 www.esr.cri.nz/digital-libr... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠 151
Rhys White @rhystwhite.bsky.social · 08/03/2024Latest #COVID19 update JN.1 dominates w/ >90% of sequenced cases & virtually all wastewater samples. JN.1.4 & XDK are now monitored; they grow 1% faster daily than other JN.1. Wastewater results show a near-complete shift to JN.1 See: www.esr.cri.nz/digital-libr... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠 0125
Rhys White @rhystwhite.bsky.social · 14/02/2024It’s out! (despite surgeries, pandemic, floods, finishing the #PhD & relocating) 📌Genomic epidemiology reveals geographical clustering of multidrug- resistant Escherichia coli ST131 associated with bacteraemia in Wales | @NatureComms doi.org/10.1038/s414... 🖥️🧬💻 #AcademicSky #Microsky 🧪🧫🦠doi.orgGenomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales - Nature CommunicationsEscherichia coli ST131 is a globally dominant multidrug resistant clone associated with high rates of recurring urinary tract infections. In this genomic epidemiology study, the authors describe the e... 063
Rhys White @rhystwhite.bsky.social · 11/02/2024Happy 9th International Day of Women and Girls in Science!🌟 I'd like to take this chance to honour the vital contributions of just a few members of our incredible #science team here at ESR in New Zealand #WomeninSTEM #WomenInScienceDay #AcademicSky #Microsky 🧪🧫🦠 7196