In this Review, Izzo et al. discuss how single-cell multimodal sequencing enables genotype–phenotype mapping and, when combined with phylogenetic reconstruction, provide insights into clonal evolution, cell state plasticity, and cancer progression, revealing mutant-specific vulnerabilities and offering a framework to study somatic evolution across pre-malignant and malignant human tissues.

This study identifies which mutations most strongly drive hepatocellular carcinoma—liver cancer—in Chinese patients by measuring each mutation's selective

Author summary Approximately 40% of estrogen receptor-positive breast cancer patients have problems in immune cell signaling at diagnosis, which can affect survival. This study introduces a new method...

Many of life's most fascinating phenomena emerge from interactions among many elements--many amino acids determine the structure of a single protein, many genes determine the fate of a cell, many neur...

The official journal of the International Society for Evolution, Medicine, and Public Health. An open access, multidisciplinary journal that publishes original, rigorous applications of evolutionary…

Nature Reviews Cancer, Published online: 06 March 2026; doi:10.1038/s41568-026-00917-zIn a study published in Cell, Xu et al. show that mast cells engineered with tumour-antigen specific antibodies and loaded with an oncolytic virus can be activated by antigen encounter to drive targeted tumour cell killing and amplify local anti-tumour immunity.

In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.

Nature Reviews Cancer, Published online: 20 January 2026; doi:10.1038/s41568-026-00907-1To preserve tumour architecture, cellular heterogeneity and the dynamic crosstalk that influences cancer, Fong and colleagues advocate for coordinated, cross-disciplinary and sustained efforts to promote the widespread adoption of tumour explants.

Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...

The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen

Be part of the revolution in cancer research and computational science with this interdisciplinary Master’s at UCL. Delivered jointly by UCL Medical Physics and Biomedical Engineering and the UCL Cancer Institute, this programme equips you with cutting-edge skills at the forefront of healthcare innovation.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Inten...

Surging applications has led the UK's main funder to look at ways to reduce the burden on reviewers

Expanded CAG repeats, the cause of Huntington’s disease, stall replication and reposition to the nuclear periphery to effect repair. Maclay et al. report that the DNA replication checkpoint targets th...

Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host B cells and drive B cell proliferation and differentiation. These Th17 cells require B cells for sustained immunit...

Tumour cells undergo profound changes in their metabolism, but targeting these metabolic pathways requires understanding of the impact on immune cells as well as cancer cells. This Review discusses ho...

Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural…

In the TRACERx cohort of 171 patients with lung cancer, the ultrasensitive detection of ctDNA improves preoperative patient stratification, also in early-stage disease.

<em>Immunology & Cell Biology</em>  is the flagship journal of the ASI, focusing on the general functioning of the immune system, with particular emphasis on its cell biology.