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kenzo ivanovitch

@kenzoivanovitch.bsky.social
206 followers 339 following 11 posts

Developmental Biologist @UCL www.ivanovitch-lab.com

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Reposted by kenzo ivanovitch
Emma R Andersson @anderssonlab.bsky.social · 23/09/2026
🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?
Schematic of method developed and application. At embryonic day 7.5, a lentiviral library carrying unique 30-nucleotide barcodes and a fluorescent reporter is injected into the mouse exocoelomic cavity. An E8 embryo cross-section shows that this cavity is continuous with the intraembryonic coelomic cavity, allowing the virus to reach and barcode mesodermal progenitors, including lateral plate and paraxial mesoderm.
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Reposted by kenzo ivanovitch
Benoit Bruneau @benoitbruneau.bsky.social · 23/07/2026
4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...
science.org
Contents | Science 393, 6809
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James Briscoe @jamesbriscoe.bsky.social · 15/07/2026
New from @vmetzis.bsky.social & co Vagal & trunk neural crest cells share transient epiblast origin, but temporal regionalisation preconfigures their identity before crest induction Cdx1 acts before Cdx2, setting distinct chromatin and HOX state in the epiblast www.biorxiv.org/content/10.6...
biorxiv.org
Temporally distinct CDX programmes preconfigure vagal and trunk neural crest
Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
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Reposted by kenzo ivanovitch
Joaquina Delas @joadelas.bsky.social · 03/07/2026
Also last week: our first review led by @jackpcw.bsky.social Cis-regulatory strategies in developmental patterning We discuss how cells choose their fate either changing their regulatory landscape or using the same elements without accessibility changes. authors.elsevier.com/sd/article/S...
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Elena Scarpa & The Squeezable Cells Lab @squeezycellslab.bsky.social · 06/06/2025
Very excited to share the first preprint from the lab: www.biorxiv.org/cgi/content/... We investigated neural crest migration all the way from head to tail of the Zebrafish embryo and we found their nuclei suffer dramatic deformations. Want to know of they cope with feeling squeezed? 🐟🐠🐟
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King's Faculty of Life Sciences & Medicine @kingslsm.bsky.social · 01/12/2025
Research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬 www.kcl.ac.uk/news/researc... Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791
kcl.ac.uk
Research reveals how cells organise to build the pancreas | King's College London
New research from King’s College London shows how different cell types develop, assemble and interact to build a functioning pancreas.
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Reposted by kenzo ivanovitch
eric lai @lucksmith.bsky.social · 12/11/2025
v sad to hear Antonio García-Bellido's passing. his work on mitotic clones led to fundamental insights such as compartment boundaries, enabled post-embryonic analysis of lethals, and revealed autonomous vs non-autonomous effects of mutants. and founding father of Spanish DB and Drosophila schools.🪰
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Reposted by kenzo ivanovitch
Giulia Boezio @giulia-boezio.bsky.social · 26/10/2025
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...
biorxiv.org
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
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Reposted by kenzo ivanovitch
Christian Mosimann @chrmosimann.bsky.social · 30/09/2025
Out @natcomms.nature.com: our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀 Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!). Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social rdcu.be/eIJm5
nature.com
The pericardium forms as a distinct structure during heart formation - Nature Communications
The developing heart integrates several progenitor cell types. Here they show that the pericardium enveloping the heart develops among cells that form the mesothelium around inner organs and body cavities, distinct from the classic heart field.
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Reposted by kenzo ivanovitch
kuba sędziński @kuba-sedzinski.bsky.social · 22/09/2025
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
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Giulia Paci @giuliapaci.bsky.social · 11/08/2025
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
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Joaquina Delas @joadelas.bsky.social · 21/07/2025
Excited to share our latest work with @jamesbriscoe.bsky.social . A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord. Congrats to all authors.
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Reposted by kenzo ivanovitch
Kevin Mitchell @wiringthebrain.bsky.social · 16/07/2025
This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)
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Reposted by kenzo ivanovitch
Vinay Ayyappan @vayyappan.bsky.social · 15/07/2025
[0/8] Stoked to share our work with @arjunraj.bsky.social on tissue organization in the gastruloid. We use lineage tracing and spatial transcriptomics to show that diversity among stem cell clones promotes, rather than hinders, gastruloid development: www.biorxiv.org/content/10.1...
biorxiv.org
Gastruloid patterning reflects division of labor among biased stem cell clones
Embryonic development typically requires precise coordination among cells to achieve reproducible outcomes, leading to the assumption that cellular heterogeneity must be minimized or buffered against....
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Reposted by kenzo ivanovitch
Vicki Metzis @vmetzis.bsky.social · 14/07/2025
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
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Reposted by kenzo ivanovitch
Michalis Averof @michalis-averof.bsky.social · 13/07/2025
We've just been awarded a grant to study the cellular basis of regeneration – to track the progenitors of sensory organs in the context of leg regeneration, in our favourite crustacean tinyurl.com/parhyale, based on live imaging and cell tracking. The project involves some cool collaborations... 1/3
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Courtney Lancaster @courtneyl7a7.bsky.social · 26/06/2025
Want to hear more about bioimaging and image analysis at UCL? Follow @biig-ucl.bsky.social This is a wonderful community for those bioimaging enthusiasts!
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Reposted by kenzo ivanovitch
The EMBO Journal @embojournal.org · 24/06/2025
Embryonic CX3CR1+ cells constitute a multipotent epiblast-derived progenitor population that contributes not only to the formation of tissue-resident macrophages, but also of cardiomyocytes and heart endothelial cells Young-sup Yoon and coworkers www.embopress.org/doi/full/10....
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Reposted by kenzo ivanovitch
The EMBO Journal @embojournal.org · 23/06/2025
Issue 12: Commentary: in vivo metabolomics in the cancer clinic Review: oxygen-sulfur interdependence ADP-ribosylation in M.tuberculosis Microprotein promoting BAT thermogenesis Cover by @kenzoivanovitch.bsky.social and colleagues www.embopress.org/toc/14602075...
This cover highlights the article Early coordination of cell migration and cardiac fate determination during mammalian gastrulation by Shayma Abukar, Kenzo Ivanovitch and colleagues. Using long-term live imaging of whole mouse embryos with light-sheet microscopy, this study tracks single cells to map how mesodermal cells coordinate their migration and fate decisions during gastrulation to drive early heart formation. The cover image shows the cardiac crescent (blue) and a late T/Bra-lineage-positive mesodermal subpopulation (red) in a DAPI-stained E7.5 mouse embryo (white). The image illustrates that late mesodermal cells contributing to the atria do not populate the cardiac crescent.

Scientific image by Kenzo Ivanovitch
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Reposted by kenzo ivanovitch
Vicki Metzis @vmetzis.bsky.social · 18/06/2025
Save the date! March 23-26 will be the dates for our 2026 @bsdb.bsky.social annual meeting: Molecules to Morphogenesis! Excited to reveal more details soon! Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :)
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Reposted by kenzo ivanovitch
Dr Jacinta Kalisch-Smith @jkalism.bsky.social · 02/06/2025
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social. journals.biologists.com/dev/article/... @idrm.ox.ac.uk Funded by the @thebhf.bsky.social
journals.biologists.com
Feto-placental blood vessel development
Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.
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James Briscoe @jamesbriscoe.bsky.social · 29/05/2025
Beautiful work from @sagnera.bsky.social & co on how spinal neurons diversify A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development A shared molecular timer driving cellular diversity www.biorxiv.org/cgi/content/...
biorxiv.org
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kenzo ivanovitch @kenzoivanovitch.bsky.social · 19/05/2025
congratulations! @shayma-a.bsky.social @yen-network.bsky.social
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Reposted by kenzo ivanovitch
Benoit Bruneau @benoitbruneau.bsky.social · 15/05/2025
Not first time thank you: pubmed.ncbi.nlm.nih.gov/36736300/
pubmed.ncbi.nlm.nih.gov
Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart - PubMed
Using four-dimensional whole-embryo light sheet imaging with improved and accessible computational tools, we longitudinally reconstruct early murine cardiac development at single-cell resolution. Nasc...
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Reposted by kenzo ivanovitch
UCL News @uclnews.bsky.social · 13/05/2025
Researchers @uclpophealthsci.bsky.social and @crick.ac.uk, led by Dr @kenzoivanovitch.bsky.social & Shayma Abukar, have, for the first time, identified the origin of cardiac cells using 3D images of a heart forming in real-time, inside a living mouse embryo www.ucl.ac.uk/news/2025/ma...
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kenzo ivanovitch @kenzoivanovitch.bsky.social · 13/05/2025
We’re excited to share the first publication from our lab, now out in @EMBOPress! @shayma-a.bsky.social @ucl.ac.uk Using live imaging in the mouse embryo, we tracked how heart progenitors migrate and assemble into the heart tube.
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Reposted by kenzo ivanovitch
Joanna Pylvänäinen @jwpylvanainen.bsky.social · 17/03/2025
Fresh from the press! @lankylaste.bsky.social, @guijacquemet.bsky.social and I put together a practical guide on how to develop software for life science applications.
doi.org
Practical recommendations for developing software for life science applications
ABSTRACT. Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scie...
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Reposted by kenzo ivanovitch
Ryan MacDonald @macdonaldlab.bsky.social · 07/02/2025
We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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James Briscoe @jamesbriscoe.bsky.social · 11/12/2024
In Praise of Peer Review As an Editor of the journal Development, I often hear complaints about peer review. We all know the problems - from lengthy review times to requests for seemingly unnecessary experiments. I agree with many of these complaints. Katherine Brown (Executive Editor of…
briscoelab.org
In Praise of Peer Review
As an Editor of the journal Development, I often hear complaints about peer review. We all know the problems - from lengthy review times to requests for seemingly unnecessary experiments. I agree with many of these complaints. Katherine Brown (Executive Editor of Development) and I recently wrote an editorial about this in which we talk about some of the things Development is doing to mitigate the worst of the problems.
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James Briscoe @jamesbriscoe.bsky.social · 02/12/2024
New @dev-journal.bsky.social editorial We know we have high standards - but we're committed to making publishing with us constructive From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science journals.biologists.com/dev/article/...
journals.biologists.com
Constructive Critics: Development's approach to peer review
We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...
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Alfonso Martinez Arias @amartinezarias.bsky.social · 28/11/2024
Using #gastruloids F. Lescroart and colleagues explore the origins of the most complex organ in our body, the #heart. Very good start of unravelling an amazing process in which an organ is being designed and redesigned at the same time it functions www.nature.com/articles/s41...
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kenzo ivanovitch @kenzoivanovitch.bsky.social · 21/11/2024
We would like to share an update of our live analysis of heart development in mouse embryos! @shayma-a.bsky.social @jamesbriscoe.bsky.social www.biorxiv.org/content/10.1...
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Anestis Tsakiridis @tsakiridis.bsky.social · 18/11/2024
Second (BBSRC Yorkshire Bioscience DTP-funded) PhD project available in our lab (jointly with @christoseland.bsky.social) examining how biomechanical cues crosstalk with signals to influence cell fate decisions during hESC differentiation. More details here: thenode.biologists.com/jobs/funded-...
thenode.biologists.com
Funded PhD Project in stem cells, mechanobiology and developmental biology - the Node
A BBSRC Yorkshire Bioscience DTP-funded PhD project (jointly with the group of Chris Toseland) focusing on the role of biomechanical cues in embryonic cell fate decisions using human pluripotent stem ...
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Mark Miodownik @markmiodownik.bsky.social · 08/11/2024
7 fully funded PhD scholarships for Black, Asian students at the start of their academic career. search.app?link=https%3...
search.app
UCL Research Opportunity Scholarship
UCL's Research Opportunity Scholarship (UCL-ROS) supports Black, Asian and ethnic minority postgraduate research degree students at the start of their academic career.
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Yanlan Mao @yanlanmao.bsky.social · 17/11/2024
Our interdisciplinary MRes is recruiting students for Sept 2025 entry : www.ucl.ac.uk/lifesciences...
ucl.ac.uk
MRes Computational Cell Biophysics
At the forefront of interdisciplinary research
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adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Thibaut Brunet @thibautbrunet.bsky.social · 06/11/2024
It was nice writing this piece and thinking about ichthyosporeans to distract myself from the absurdity of the world over the past weeks. With perfect comedic (or tragic) timing, it came out today. Check it out if you need a distraction from the absurdity of the world. www.nature.com/articles/d41...
nature.com
Clues to the origin of embryonic development in animals
Cell division analysed of a distant relative of animals.
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