Conjugative plasmids are major drivers of antibiotic resistance dissemination, yet how newly transferred plasmids establish in recipient cells remains poorly understood. Here we investigate YfjB, a pr...

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Nature Structural & Molecular Biology - This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs,...

In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...

MicroRNAs guide Argonaute proteins to repress gene expression. Here, the authors define the binding rules for five Drosophila miRNAs, showing a narrow preference for canonical seed sites and identifyi...

Most pachytene PIWI-interacting RNAs (piRNAs) have no biological function; however, a small population enhances sperm fitness, which has led to their persistence in mammalian evolution.

La recherche sur les troubles du neurodéveloppement (TND) vient de franchir un nouveau cap grâce à cette récente étude sur le rôle du gène DDX17 dans le développement neuronal.

Avec « Qu’est-ce que tu cherches ? », le podcast science du CNRS, partez à la rencontre des scientifiques, découvrez leur quotidien, leur domaine de recherche, leurs avancées et ce qui les motive. Dan...

Le patrimoine génétique est propre à chaque individu et c’est ce qui le rend unique ! C’est même le cas pour de vrais jumeaux, bien qu’ayant grandi dans le même environnement, ils se retrouvent souven...

Researchers at academic institutions nationwide say that U.S. science is being dismantled.

Here, integrating ribosome profiling, RNA-seq and proteomics to reveal transcriptional and post-translational regulation in HIV-infected T cells, the authors show that non-AUG translation of viral ups...

Beta-propeller protein-associated neurodegeneration (BPAN) is a rare neurological disease characterized by severe cognitive and motor impairments. BPAN is caused by de novo pathogenic variants in the ...

Chromosomes are long strings of DNA carrying multiple genes. A chromosomal factor called cohesin creates loops of DNA proposed to be functional units of the genome. By contrast, it is proposed here th...

Many new small RNA species and their derived fragments have been recently identified in animals. This Review discusses the biogenesis and functions of both structural small RNAs, such as tRNAs and sma...

In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...

Abstract. We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to a new server and the creation

Ce mercredi 27 novembre, le collège Le Calloud a vibré au rythme de la science et de la recherche. Dans le cadre de l’opération nationale “1 000 ...