Taillefer et al. show that a bacterial type VI secretion system is lost or attenuated during experimental evolution when it provides no competitive advantage but is maintained in the presence of susceptible competitors. T6SS inactivation arises through diverse regulatory and structural mutations, revealing how ecological context shapes antibacterial weapon evolution.

Taillefer et al. show that a bacterial type VI secretion system is lost or attenuated during experimental evolution when it provides no competitive advantage but is maintained in the presence of susce...

Contact: secretion@imm.cnrs.fr

Paillat et al. show that Flavobacterium johnsoniae combines type VI and type IX secretion systems with gliding motility to efficiently kill diverse bacterial competitors. They demonstrate that nutrien...

Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t

Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we ...

The genetic basis underlying non-tuberculous mycobacteria (NTM) pathogenesis remains poorly understood. This gap in knowledge has been partially filled over the years through the generation of novel a...

Contact: secretion@imm.cnrs.fr

Contact: secretion@imm.cnrs.fr

Maxence Joscht est doctorant à l'EHESS au sein du Centre de recherche sur les circulations, les liens et les échanges (CeRCLEs - EHESS), sous la direction dEleonora Canepari....